gefitinib has been researched along with desipramine in 8 studies
| Studies (gefitinib) | Trials (gefitinib) | Recent Studies (post-2010) (gefitinib) | Studies (desipramine) | Trials (desipramine) | Recent Studies (post-2010) (desipramine) |
|---|---|---|---|---|---|
| 5,231 | 566 | 2,919 | 5,775 | 487 | 414 |
| Protein | Taxonomy | gefitinib (IC50) | desipramine (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 1 | Homo sapiens (human) | 9.18 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.35 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0003 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.35 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0034 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0003 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0003 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.35 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.0031 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 7.8 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.35 | |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | 0.0008 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.1961 | |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.35 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0003 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 3.8 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 9.9 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 1.4035 | |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | 1.52 | |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.35 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.35 | |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | 10 | |
| Transporter | Rattus norvegicus (Norway rat) | 7.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
1 review(s) available for gefitinib and desipramine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
7 other study(ies) available for gefitinib and desipramine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |