gefitinib has been researched along with cyclopamine in 9 studies
| Studies (gefitinib) | Trials (gefitinib) | Recent Studies (post-2010) (gefitinib) | Studies (cyclopamine) | Trials (cyclopamine) | Recent Studies (post-2010) (cyclopamine) |
|---|---|---|---|---|---|
| 5,231 | 566 | 2,919 | 658 | 0 | 343 |
| Protein | Taxonomy | gefitinib (IC50) | cyclopamine (IC50) |
|---|---|---|---|
| Integrin beta-1 | Homo sapiens (human) | 1.312 | |
| Integrin alpha-4 | Homo sapiens (human) | 1.312 | |
| Smoothened homolog | Mus musculus (house mouse) | 1.271 | |
| Sonic hedgehog protein | Homo sapiens (human) | 0.6 | |
| Sonic hedgehog protein | Mus musculus (house mouse) | 0.7373 | |
| Smoothened homolog | Homo sapiens (human) | 0.2147 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Batra, SK; Depreux, P; Hénichart, JP; Lin, MF; Mimeault, M; Moniaux, N; Moore, E | 1 |
| Bonde, P; Broor, A; Dhara, S; Duncan, M; Feldmann, G; Harmon, JW; Maitra, A; Marti, G; Montgomery, E; Sui, G; Wang, J | 1 |
| Batra, SK; Depreux, P; Henichart, JP; Johansson, SL; Lin, MF; Mimeault, M; Moore, E; Vankatraman, G | 1 |
| Hu, WG; Liu, T; Wang, CY; Xiong, JX | 1 |
| Batra, SK; Depreux, P; Hauke, R; Henichart, JP; Lin, MF; Mehta, PP; Mimeault, M | 1 |
| Batra, SK; Depreux, P; Henichart, JP; Johansson, SL; Mimeault, M | 1 |
| Behrman, SW; Chitkara, D; Danquah, M; Kumar, N; Kumar, V; Mahato, RI; Singh, S | 1 |
| Che, J; Shen, XJ; Sun, KK; Wu, XY; Yang, D; Zhao, H; Zhong, N | 1 |
9 other study(ies) available for gefitinib and cyclopamine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Proliferation; DNA Damage; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Hedgehog Proteins; Humans; Male; Prostatic Neoplasms; Quinazolines; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Veratrum Alkaloids | 2006 |
Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model.
Topics: Animals; Apoptosis; Cell Line, Tumor; ErbB Receptors; Esophageal Neoplasms; Gefitinib; Hedgehog Proteins; Male; MAP Kinase Signaling System; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Trans-Activators; Veratrum Alkaloids | 2006 |
Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Cytochromes c; Docetaxel; ErbB Receptors; Gefitinib; Hedgehog Proteins; Humans; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Neoplasm Invasiveness; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Quinazolines; Signal Transduction; Taxoids; Tumor Cells, Cultured; Veratrum Alkaloids | 2007 |
Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Proliferation; ErbB Receptors; Gefitinib; Hedgehog Proteins; Humans; Pancreatic Neoplasms; Quinazolines; Signal Transduction; Veratrum Alkaloids | 2007 |
Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Synergism; ErbB Receptors; Gefitinib; Hedgehog Proteins; Humans; Hydrogen Peroxide; Male; Membrane Potential, Mitochondrial; Mitoxantrone; Neoplasm Invasiveness; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Quinazolines; Signal Transduction; Veratrum Alkaloids | 2007 |
Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells.
Topics: Adenocarcinoma; Apoptosis; Cell Fractionation; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Docetaxel; Drug Evaluation, Preclinical; ErbB Receptors; Gefitinib; Humans; Male; Neoplasm Invasiveness; Phosphorylation; Prostate; Prostatic Neoplasms; Quinazolines; Taxoids; Transcription Factors; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2010 |
Micellar delivery of cyclopamine and gefitinib for treating pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gefitinib; Humans; Male; Mice; Mice, Nude; Micelles; Pancreatic Neoplasms; Quinazolines; Veratrum Alkaloids | 2012 |
Cyclopamine increases the radiosensitivity of human pancreatic cancer cells by regulating the DNA repair signal pathway through an epidermal growth factor receptor‑dependent pathway.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Repair; ErbB Receptors; Gefitinib; Histones; Humans; Pancreatic Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Veratrum Alkaloids | 2013 |