Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and curcumin

gefitinib has been researched along with curcumin in 5 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(curcumin)		Trials
(curcumin)		Recent Studies (post-2010) (curcumin)
5,2315662,91916,33659312,705

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)curcumin (IC50)
toll-like receptor 9Homo sapiens (human)8.362
TPA: protein transporter TIM10Saccharomyces cerevisiae S288C19.7
intestinal alkaline phosphatase precursorMus musculus (house mouse)18.7
perilipin-1Homo sapiens (human)9.167
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)9.167
hypothetical protein SA1422Staphylococcus aureus subsp. aureus N31542.9
Prostaglandin E synthaseHomo sapiens (human)1.8
Lysine-specific histone demethylase 1AHomo sapiens (human)9.6
D-amino-acid oxidaseSus scrofa (pig)1.07
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)3
Amyloid-beta precursor proteinHomo sapiens (human)4.3079
Neuronal proto-oncogene tyrosine-protein kinase Src Mus musculus (house mouse)2.2
Heme oxygenase 1 Rattus norvegicus (Norway rat)10
Microtubule-associated protein tauHomo sapiens (human)3.25
60 kDa heat shock protein, mitochondrialHomo sapiens (human)8.3
Tissue factorHomo sapiens (human)0.0132
TyrosinaseHomo sapiens (human)5
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)5.4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiens (human)7
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)0.066
Amine oxidase [flavin-containing] AHomo sapiens (human)3.5
Heme oxygenase 2Rattus norvegicus (Norway rat)10
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)5.4
Amine oxidase [flavin-containing] BHomo sapiens (human)2.5733
Proteasome subunit beta type-5Homo sapiens (human)10
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)1.73
Alpha-synucleinHomo sapiens (human)0.22
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)5.4
10 kDa heat shock protein, mitochondrialHomo sapiens (human)8.3
Histone acetyltransferase p300Homo sapiens (human)6.5
60 kDa chaperonin Escherichia coli3
10 kDa chaperonin Escherichia coli3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiens (human)7
Cysteine protease Trypanosoma brucei rhodesiense7.75
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)2.36
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.63
Beta lactamase (plasmid)Pseudomonas aeruginosa7.751

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF1
Chang, GC; Chen, HW; Chen, JJ; Hsieh, WY; Lee, JY; Lee, YM; Yang, PC; Yu, SL1
Chen, CG; Chen, K; Chen, P; Huang, HP; Jin, J; Li, J; Long, WG; Wang, Y; Zhao, XH1
Cheng, ZY; Chueh, FS; Chung, JG; Hsiao, YT; Lai, KC; Lien, JC; Liu, KC; Peng, SF1
Chen, HM; Chen, HY; Chiang, CP; Li, WC; Lin, HY; Wei, YC; Yang, H1

Reviews

1 review(s) available for gefitinib and curcumin

ArticleYear
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells

2022

Other Studies

4 other study(ies) available for gefitinib and curcumin

ArticleYear
Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; ErbB Receptors; Gefitinib; Humans; Intestinal Mucosa; Intestines; Lung Neoplasms; Mice; Mice, SCID; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Ubiquitination; Xenograft Model Antitumor Assays

2011
Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death.
    Journal of experimental & clinical cancer research : CR, 2019, Jun-13, Volume: 38, Issue:1

    Topics: Animals; Antineoplastic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Curcumin; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mutation; Protein Binding; Proto-Oncogene Proteins p21(ras); Signal Transduction

2019
Gefitinib and curcumin-loaded nanoparticles enhance cell apoptosis in human oral cancer SAS cells in vitro and inhibit SAS cell xenografted tumor in vivo.
    Toxicology and applied pharmacology, 2019, 11-01, Volume: 382

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Curcumin; Gefitinib; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Nanoparticles; Protein Kinase Inhibitors; Xenograft Model Antitumor Assays

2019
Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment.
    Biomolecules, 2020, 09-17, Volume: 10, Issue:9

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Catechin; Cell Line, Tumor; Cell Survival; Curcumin; Gefitinib; Humans; Kaplan-Meier Estimate; Mouth Neoplasms; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents

2020