Page last updated: 2024-09-03

gefitinib and celastrol

gefitinib has been researched along with celastrol in 3 studies

Compound Research Comparison

Studies
(gefitinib)
Trials
(gefitinib)
Recent Studies (post-2010)
(gefitinib)
Studies
(celastrol)
Trials
(celastrol)
Recent Studies (post-2010) (celastrol)
5,2315662,9198851741

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)celastrol (IC50)
Telomerase reverse transcriptaseHomo sapiens (human)0.78
Ubiquitin carboxyl-terminal hydrolase 2Homo sapiens (human)6.8
Ubiquitin carboxyl-terminal hydrolase isozyme L1Homo sapiens (human)6.8
Indoleamine 2,3-dioxygenase 1Homo sapiens (human)8.41
Ubiquitin carboxyl-terminal hydrolase isozyme L3Homo sapiens (human)6.8
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)3.45
Tyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)3.1
Tyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)3.5667
Hypoxia-inducible factor 1-alphaHomo sapiens (human)0.25
Regulator of G-protein signaling 17Homo sapiens (human)6.1795
Ubiquitin carboxyl-terminal hydrolase 15Homo sapiens (human)6.8
Ubiquitin carboxyl-terminal hydrolase isozyme L5Homo sapiens (human)6.8

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fan, XX; He, JX; Leung, EL; Li, N; Liu, L; Wu, JL; Zhou, YL1
Coghi, PS; Fan, XX; Law, BY; Leung, CH; Leung, EL; Liu, L; Ma, DL; Mok, SW; Wong, VK; Xu, SW; Zeng, W1
Kim, SY; Lee, C; Lee, YJ1

Other Studies

3 other study(ies) available for gefitinib and celastrol

ArticleYear
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
    Molecules (Basel, Switzerland), 2014, Mar-21, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gefitinib; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mitochondria; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proteolysis; Quinazolines; Signal Transduction; Triterpenes

2014
Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.
    International journal of oncology, 2016, Volume: 49, Issue:4

    Topics: Antineoplastic Agents; Autophagy; Blotting, Western; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Flow Cytometry; Gefitinib; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Proteolysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triterpenes; Tumor Cells, Cultured

2016
Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells.
    Molecular medicine reports, 2019, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Axl Receptor Tyrosine Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Humans; Lung Neoplasms; Mutation; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Triterpenes

2019