Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and bosutinib

gefitinib has been researched along with bosutinib in 10 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(bosutinib)		Trials
(bosutinib)		Recent Studies (post-2010) (bosutinib)
5,2315662,91936450290

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)bosutinib (IC50)
Serine/threonine-protein kinase 10Homo sapiens (human)0.052
Tyrosine-protein kinase ABL1Homo sapiens (human)0.0422
Epidermal growth factor receptorHomo sapiens (human)0.272
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.6
High affinity nerve growth factor receptorHomo sapiens (human)0.022
Tyrosine-protein kinase LckHomo sapiens (human)0.0013
Tyrosine-protein kinase FynHomo sapiens (human)0.2739
NucleophosminHomo sapiens (human)0.175
Tyrosine-protein kinase Fes/FpsHomo sapiens (human)0.358
Tyrosine-protein kinase YesHomo sapiens (human)0.0004
Tyrosine-protein kinase LynHomo sapiens (human)0.008
Tyrosine-protein kinase HCKHomo sapiens (human)0.0032
Tyrosine-protein kinase FgrHomo sapiens (human)0.0011
Mast/stem cell growth factor receptor KitHomo sapiens (human)1.886
Glycogen phosphorylase, muscle formHomo sapiens (human)0.0012
Breakpoint cluster region proteinHomo sapiens (human)0.0107
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0228
Tyrosine-protein kinase BlkMus musculus (house mouse)0.0073
Tyrosine-protein kinase FerHomo sapiens (human)0.49
Platelet-derived growth factor receptor alphaRattus norvegicus (Norway rat)4
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.0013
Ephrin type-A receptor 2Homo sapiens (human)0.002
Ephrin type-B receptor 2Homo sapiens (human)0.0085
Tyrosine-protein kinase receptor UFOHomo sapiens (human)0.4085
Tyrosine-protein kinase CSKHomo sapiens (human)0.063
Tyrosine-protein kinase TecHomo sapiens (human)0.282
Tyrosine-protein kinase TXKHomo sapiens (human)0.04
Tyrosine-protein kinase ABL2Homo sapiens (human)0.0009
Tyrosine-protein kinase FRKHomo sapiens (human)0.0022
Tyrosine-protein kinase SYKHomo sapiens (human)0.052
Cytoplasmic tyrosine-protein kinase BMXHomo sapiens (human)0.0044
Ephrin type-B receptor 4Homo sapiens (human)0.0055
Synaptic vesicular amine transporterRattus norvegicus (Norway rat)0.1
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)0.001
Angiopoietin-1 receptorHomo sapiens (human)1.191
Platelet-derived growth factor receptor betaRattus norvegicus (Norway rat)4
Focal adhesion kinase 1Homo sapiens (human)0.538
Tyrosine-protein kinase BTKHomo sapiens (human)0.0025
Activated CDC42 kinase 1Homo sapiens (human)0.0027
Mitogen-activated protein kinase kinase kinase kinase 2Homo sapiens (human)0.0099
Serine/threonine-protein kinase 4Homo sapiens (human)0.191
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)0.184
Protein-tyrosine kinase 2-betaHomo sapiens (human)0.134
BDNF/NT-3 growth factors receptorHomo sapiens (human)0.027
Calcium/calmodulin-dependent protein kinase type 1DHomo sapiens (human)0.092
Misshapen-like kinase 1Homo sapiens (human)0.022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseHomo sapiens (human)0.4185
Interleukin-1 receptor-associated kinase 4Homo sapiens (human)0.574
Serine/threonine-protein kinase TBK1Homo sapiens (human)0.5705
ALK tyrosine kinase receptorHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)2
Mitogen-activated protein kinase kinase kinase kinase 5Homo sapiens (human)0.0003
Serine/threonine-protein kinase 24Homo sapiens (human)0.0039

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (70.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Morphy, R1
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Capuzzi, SJ; Fisher, EG; García-Sastre, A; He, S; Li, H; Martínez-Romero, C; Muratov, EN; Qiu, X; Shinn, P; Sun, W; Tawa, G; Tropsha, A; Xu, M; Zheng, W; Zhu, W1
Asquith, CRM; Drewry, DH; East, MP; Havener, TM; Johnson, GL; Laitinen, T; Morris, DC; Naegeli, KM; Wells, CI; Zuercher, WJ1
Asquith, CRM; Treiber, DK; Zuercher, WJ1
Bharate, SB; Raghuvanshi, R1
Caballero, E; García-Cárceles, J; Gil, C; Martínez, A1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF1
Farias-Hesson, E; Finigan, JH; Heasley, LE; Kang, J; Kern, JA; Kim, J; Leach, SM; Mason, RJ; Mishra, R; Ramamoorthy, P; Singleton, KR; Tan, AC; Vasu, VT; Yoo, M1

Reviews

3 review(s) available for gefitinib and bosutinib

ArticleYear
Selectively nonselective kinase inhibition: striking the right balance.
    Journal of medicinal chemistry, 2010, Feb-25, Volume: 53, Issue:4

    Topics: Animals; Antineoplastic Agents; Drug Design; Drug Discovery; Humans; Protein Binding; Protein Kinase Inhibitors; Structure-Activity Relationship

2010
Kinase Inhibitors as Underexplored Antiviral Agents.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

2022
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells

2022

Other Studies

7 other study(ies) available for gefitinib and bosutinib

ArticleYear
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.
    Journal of medicinal chemistry, 2018, 04-26, Volume: 61, Issue:8

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Drug Discovery; Drug Evaluation, Preclinical; Ebolavirus; HeLa Cells; Humans; Molecular Structure; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Virus Internalization

2018
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
    Journal of medicinal chemistry, 2019, 05-09, Volume: 62, Issue:9

    Topics: Aminoquinolines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chordoma; Drug Design; ErbB Receptors; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines

2019
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
    Bioorganic & medicinal chemistry letters, 2019, 07-15, Volume: 29, Issue:14

    Topics: Cyclin G; Humans; Protein Kinase Inhibitors; Quinolines

2019
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

2022
Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.
    Bioinformatics (Oxford, England), 2014, Sep-01, Volume: 30, Issue:17

    Topics: Aniline Compounds; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Computational Biology; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Nitriles; Protein Kinase Inhibitors; Protein Kinases; Quinazolines; Quinolines; Sequence Analysis, RNA

2014
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