Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and ag 1879

gefitinib has been researched along with ag 1879 in 5 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(ag 1879)		Trials
(ag 1879)		Recent Studies (post-2010) (ag 1879)
5,2315662,9195750215

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)ag 1879 (IC50)
Chain A, Lck KinaseHomo sapiens (human)0.02
Chain A, Tyrosine-protein kinase LynMus musculus (house mouse)0.009
Chain A, Tyrosine-protein kinase LynMus musculus (house mouse)0.009
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.019
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.036
Epidermal growth factor receptorHomo sapiens (human)0.48
Tyrosine-protein kinase LckHomo sapiens (human)0.004
Proto-oncogene tyrosine-protein kinase LCK Mus musculus (house mouse)0.031
Tyrosine-protein kinase FynHomo sapiens (human)0.0052
Tyrosine-protein kinase LynHomo sapiens (human)0.0005
Tyrosine-protein kinase HCKHomo sapiens (human)0.005
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)1.1814
Tyrosine-protein kinase CSKHomo sapiens (human)0.5
Casein kinase I isoform deltaHomo sapiens (human)0.041
Mitogen-activated protein kinase 14Homo sapiens (human)4.23

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Chen, YR; Cheng, HH; Fu, YN; Huang, SF; Tsai, SF; Yang, CH; Yeh, CL1
Jeong, YJ; Kim, CH; Kim, DJ; Kim, JC; Lee, KB; Oh, SM; Park, JH1
Jensen, RT; Moody, TW; Moreno, P; Nuche-Berenguer, B1

Other Studies

5 other study(ies) available for gefitinib and ag 1879

ArticleYear
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.
    Oncogene, 2008, Feb-07, Volume: 27, Issue:7

    Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Exons; Gefitinib; Humans; Immunoprecipitation; Lung Neoplasms; Phosphorylation; Point Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Quinazolines; Sequence Deletion; Tyrosine

2008
RIP2/RICK-dependent cytokine production upon Yersinia enterocolitica infection in macrophages with TLR4 deficiency.
    Scandinavian journal of immunology, 2013, Volume: 78, Issue:5

    Topics: Animals; Enzyme Inhibitors; Gefitinib; Imidazoles; Interleukin-10; Interleukin-6; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Nod1 Signaling Adaptor Protein; Nod2 Signaling Adaptor Protein; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinazolines; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Yersinia enterocolitica; Yersinia Infections

2013
CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.
    Journal of molecular neuroscience : MN, 2015, Volume: 56, Issue:3

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dipeptides; ErbB Receptors; Gastrins; Gefitinib; Hormone Antagonists; Humans; Indoles; Lung Neoplasms; Meglumine; Pyrimidines; Quinazolines

2015