Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and acridines

gefitinib has been researched along with acridines in 3 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(acridines)		Trials
(acridines)		Recent Studies (post-2010) (acridines)
5,2315662,9196,987169856

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)acridines (IC50)
AcetylcholinesteraseHomo sapiens (human)6.84

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fukumura, T; Hatori, A; Irie, T; Kanno, I; Kawamura, K; Konno, F; Kumata, K; Suzuki, K; Yamasaki, T; Yui, J; Zhang, MR1
Agarwal, S; Elmquist, WF; Gallardo, JL; Ohlfest, JR; Sane, R1
DeGroot, J; Jansen, HT; Kivits, S; Läppchen, T; Sio, CF; Steinbach, OC; van de Steeg, E; van der Hoorn, JW; van Driel, A; Vlaming, ML1

Other Studies

3 other study(ies) available for gefitinib and acridines

ArticleYear
In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [(11)C]gefitinib.
    Nuclear medicine and biology, 2009, Volume: 36, Issue:3

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain; Carbon Radioisotopes; Gefitinib; Male; Mice; Neoplasm Proteins; Positron-Emission Tomography; Quinazolines; Radioactivity; Tetrahydroisoquinolines

2009
Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:1

    Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Brain; Cell Line; Cell Membrane Permeability; Dogs; Gefitinib; Male; Mice; Mice, Knockout; Quinazolines; Tetrahydroisoquinolines; Tissue Distribution; Transfection

2010
PET-CT imaging with [(18)F]-gefitinib to measure Abcb1a/1b (P-gp) and Abcg2 (Bcrp1) mediated drug-drug interactions at the murine blood-brain barrier.
    Nuclear medicine and biology, 2015, Volume: 42, Issue:11

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Cell Line, Tumor; Drug Interactions; Fluorine Radioisotopes; Gefitinib; Humans; Male; Mice; Positron-Emission Tomography; Quinazolines; Tetrahydroisoquinolines; Tissue Distribution; Tomography, X-Ray Computed

2015