Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and PP121

gefitinib has been researched along with PP121 in 3 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(PP121)		Trials
(PP121)		Recent Studies (post-2010) (PP121)
5,2315662,91916013

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)PP121 (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.15
Tyrosine-protein kinase ABL1Homo sapiens (human)0.0127
Epidermal growth factor receptorHomo sapiens (human)0.26
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.001
Tyrosine-protein kinase HCKHomo sapiens (human)0.008
Breakpoint cluster region proteinHomo sapiens (human)0.018
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.014
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.0217
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.052
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)1.4
Serine/threonine-protein kinase mTORHomo sapiens (human)0.01
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)1.1
Ephrin type-B receptor 4Homo sapiens (human)0.19
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)0.06
Serine/threonine-protein kinase ATRHomo sapiens (human)1.42
Phosphatidylinositol 4-kinase betaHomo sapiens (human)0.06

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aizenstein, B; Apsel, B; Blair, JA; Feldman, ME; Gonzalez, B; Hoffman, R; Knight, ZA; Nazif, TM; Shokat, KM; Williams, RL1
Morphy, R1
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1

Reviews

1 review(s) available for gefitinib and PP121

ArticleYear
Selectively nonselective kinase inhibition: striking the right balance.
    Journal of medicinal chemistry, 2010, Feb-25, Volume: 53, Issue:4

    Topics: Animals; Antineoplastic Agents; Drug Design; Drug Discovery; Humans; Protein Binding; Protein Kinase Inhibitors; Structure-Activity Relationship

2010

Other Studies

2 other study(ies) available for gefitinib and PP121

ArticleYear
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
    Nature chemical biology, 2008, Volume: 4, Issue:11

    Topics: Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Blotting, Western; Catalytic Domain; Cell Proliferation; Cells, Cultured; Crystallography, X-Ray; Drug Delivery Systems; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Protein Subunits; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Sequence Alignment; Signal Transduction; TOR Serine-Threonine Kinases

2008
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011