gefarnate has been researched along with farnesylacetic-acid* in 2 studies
2 other study(ies) available for gefarnate and farnesylacetic-acid
Article | Year |
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An improved method for 14C-labelling of farnesylacetic acid and its geranyl ester.
Farnesylacetic acid was efficiently labelled with 14C at the 5-position and gefarnate, a potent ulcer inhibitor, was prepared from it in radioactive form for use in metabolic studies. Condensation of [carbonyl-14C]acetyl chloride (5) with t-butyl 2-ethoxymagnesiomalonate (6) followed by acid-catalyzed deprotection and decarboxylation gave ethyl 3-oxo[3-14C]butanoate (8). Alkylation of the keto ester (8) with geranyl bromide (9) afforded the unsaturated keto ester (10), which was hydrolyzed and decarboxylated to give geranyl[2-14C]acetone (11). Grignard reaction of 11 with cyclopropylmagnesium bromide followed by treatment with hydrobromic acid yielded [4-14C]homofarnesyl bromide (13). Cyanation of 13 with potassium cyanide and subsequent hydrolysis gave [5-14C]farnesylacetic acid (1) in 6.1% yield from barium [14C]carbonate (3). Chlorination of 1 followed by esterification with geraniol afforded [5-14C]gefarnate (2) in 88% yield. Topics: Carbon Radioisotopes; Farnesol; Gefarnate; Isotope Labeling; Terpenes | 1988 |
[THERAPY OF PEPTIC ULCER WITH GEFARNATE, GERANYL FARNESYL ACETATE].
Topics: Drug Therapy; Farnesol; Gefarnate; Humans; Peptic Ulcer; Terpenes | 1965 |