gdc-0941 has been researched along with osimertinib* in 1 studies
1 other study(ies) available for gdc-0941 and osimertinib
| Article | Year |
|---|---|
Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
Four series of thiopyranopyrimidine AZD9291 derivatives containing acrylamide structure were designed, synthesized and evaluated for their antiproliferative activity against A549 and Hela cancer cells. Most of the compounds exhibited excellent antiproliferative activity against A549 cells. Moreover, the compounds with indole ring fluorine substituted exhibited better antiproliferative activity against Hela cells. The most promising compound 23g exhibited excellent enzymatic inhibitory activity and selectivity for EGFR Topics: A549 Cells; Acrylamides; Aniline Compounds; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Molecular Docking Simulation; Molecular Structure; Quantitative Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |