Page last updated: 2024-09-03

gbr 13069 and flunarizine

gbr 13069 has been researched along with flunarizine in 5 studies

Compound Research Comparison

Studies
(gbr 13069)
Trials
(gbr 13069)
Recent Studies (post-2010)
(gbr 13069)
Studies
(flunarizine)
Trials
(flunarizine)
Recent Studies (post-2010) (flunarizine)
6001,269189153

Protein Interaction Comparison

ProteinTaxonomygbr 13069 (IC50)flunarizine (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.669
Bile salt export pumpHomo sapiens (human)10
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.49
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.339
Muscarinic acetylcholine receptor M4Homo sapiens (human)5.656
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.107
Alpha-2A adrenergic receptorHomo sapiens (human)0.581
Adenosine receptor A3Homo sapiens (human)5.198
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.936
Cytochrome P450 2C9 Homo sapiens (human)0.94
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.6058
D(2) dopamine receptorHomo sapiens (human)0.352
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)5.198
Alpha-2B adrenergic receptorHomo sapiens (human)1.893
Alpha-2C adrenergic receptorHomo sapiens (human)0.222
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4.281
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.479
Cannabinoid receptor 1Homo sapiens (human)3.028
D(1A) dopamine receptorHomo sapiens (human)3.874
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.339
Alpha-1D adrenergic receptorHomo sapiens (human)1.085
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.407
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.669
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)4.281
Sodium-dependent serotonin transporterHomo sapiens (human)0.499
Delta-type opioid receptorMus musculus (house mouse)1.67
Histamine H1 receptorHomo sapiens (human)0.158
Mu-type opioid receptorHomo sapiens (human)5.236
D(3) dopamine receptorHomo sapiens (human)0.097
5-hydroxytryptamine receptor 2BHomo sapiens (human)1.088
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)5.198
Cytochrome P450 2J2Homo sapiens (human)0.8833
Voltage-dependent L-type calcium channel subunit beta-1Rattus norvegicus (Norway rat)0.08
Voltage-dependent calcium channel subunit alpha-2/delta-1Rattus norvegicus (Norway rat)0.08
D(2) dopamine receptorRattus norvegicus (Norway rat)0.228
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)1.67
Sodium-dependent dopamine transporter Homo sapiens (human)0.584
Voltage-dependent N-type calcium channel subunit alpha-1BRattus norvegicus (Norway rat)0.08
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.6058
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.6058
Potassium channel subfamily K member 2 Bos taurus (cattle)2.5
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.025
Prostaglandin D2 receptor 2Homo sapiens (human)0.08

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heikkila, RE; Nicklas, WJ; Youngster, SK1
Heikkila, RE; Manzino, L; Sonsalla, PK1
Gerhardt, GA; Gratton, A; Hoffer, BJ; Wise, RA1
Heikkila, RE; Kindt, MV; Mayer, RA1
Heikkila, RE; Manzino, L1

Other Studies

5 other study(ies) available for gbr 13069 and flunarizine

ArticleYear
Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. II. Evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of MPTP a
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Dopamine; Dopamine Antagonists; Flunarizine; Male; Mice; Mitochondria; Monoamine Oxidase; Oxidation-Reduction; Pyridines; Pyridinium Compounds; Structure-Activity Relationship

1989
Interactions of D1 and D2 dopamine receptors on the ipsilateral vs. contralateral side in rats with unilateral lesions of the dopaminergic nigrostriatal pathway.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Basal Ganglia; Benzazepines; Corpus Striatum; Denervation; Dextroamphetamine; Ergolines; Female; Flunarizine; Functional Laterality; Haloperidol; Levodopa; Neural Pathways; Parkinson Disease; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Substantia Nigra

1988
Potentiation of morphine-elicited circling by dopaminergic uptake blockade.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Dopamine Antagonists; Drug Synergism; Flunarizine; Male; Morphine; Naloxone; Nomifensine; Rats; Rats, Inbred Strains; Reference Values; Stereotyped Behavior; Tegmentum Mesencephali

1988
Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport.
    Journal of neurochemistry, 1986, Volume: 47, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Flunarizine; Male; Mice; Nalidixic Acid; Naphthyridines; Piperazines; Pyridines; Pyridinium Compounds; Pyrroles; Rats; Rats, Inbred Strains; Substantia Nigra

1986
Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake.
    European journal of pharmacology, 1984, Aug-17, Volume: 103, Issue:3-4

    Topics: Animals; Behavior, Animal; Biogenic Amines; Cerebral Cortex; Corpus Striatum; Dopamine; Female; Flunarizine; Haloperidol; Humans; Hydroxydopamines; In Vitro Techniques; Male; Mice; Motor Activity; Neurotransmitter Uptake Inhibitors; Oxidopamine; Piperazines; Rats; Rats, Inbred Strains; Stereotyped Behavior

1984