Page last updated: 2024-08-16

gatifloxacin and isoniazid

gatifloxacin has been researched along with isoniazid in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (50.00)	29.6817
2010's	16 (44.44)	24.3611
2020's	2 (5.56)	2.80

Authors

Authors	Studies
Pavana, RK; Sriram, D; Thirumurugan, R; Yogeeswari, P	1
Kumar, RR; Perumal, S; Senthilkumar, P; Sriram, D; Yogeeswari, P	1
China, A; Dinakaran, M; Nagaraja, V; Senthilkumar, P; Sriram, D; Yogeeswari, P	3
Banerjee, D; China, A; Devakaram, RV; Dinakaran, M; Nagaraja, V; Senthilkumar, P; Sriram, D; Yogeeswari, P	1
Bitting, C; Gruppo, V; Johnson, CM; Lenaerts, AJ; Marietta, KS; Orme, IM; Woolhiser, L	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ackerman, M; Cynamon, MH; Pucci, MJ; Shoen, CM; Thanassi, JA	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Baulard, AR; Crauste, C; Déprez, B; Flipo, M; Villemagne, B; Willand, N	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Feng, LS; Gao, C; Hu, YQ; Lv, ZS; Wu, X; Xu, Z; Zhang, S; Zhao, F	1
Cheng, XW; Fan, YL; Feng, LS; Wu, JB; Zhang, FZ	1
Bai, L; Deng, JL; Gao, F; Lv, ZS; Wang, Y; Xu, Z; Zhang, F; Zhao, SJ	1
Chen, L; Chen, Z; Fan, Y; Gao, F; Lu, G; Ma, L	1
Dhawan, S; Girase, PS; Karpoormath, R; Kumar, V; Palkar, MB; Shinde, SR	1
Alvirez-Freites, EJ; Carter, JL; Cynamon, MH	1
Cynamon, MH; DeStefano, MS; Monica, BJ; Shoen, CM; Sklaney, MR; Slee, AM	1
Kubendiran, G; Mitchison, DA; Paramasivan, CN; Sulochana, S; Venkatesan, P	1
Kubendiran, G; Mitchison, DA; Paramasivan, CN; Sulochana, S	1
Cynamon, M; Shoen, C; Sklaney, MR	1
Fourie, PB; Horton, J; Kanyok, TP; McIlleron, H; Norman, J; Smith, PJ	1
Krinke, GJ; Wells, MY	1
Allen, J; Coleman, DJ; Davies, GR; Fourie, B; Kanyok, T; Levin, J; Lienhardt, C; Mitchison, DA; Mthiyane, T; Reddy, C; Rustomjee, R; Sirgel, FA; Sturm, AW	1
Jhamb, SS; Singh, PP	1
Cai, HL; Chen, YC; Fang, PF; Gao, W; Li, HD; Liu, YP; Tan, QY; Xu, P; Zhang, F; Zhang, WY; Zhu, RH	1
Ambrose, PG; Bhavnani, SM; Caws, M; Chau, TT; Dung, NT; Farrar, J; Hammel, JP; Hien, TT; Kulawy, R; Mai, PP; Reynolds, DK; Thwaites, GE; Török, ME; Van Wart, SA	1
Bah-Sow, O; Gninafon, M; Horton, J; Lienhardt, C; Lo, MB; McIlleron, H; Merle, CS; Olliaro, PL; Rustomjee, R; Simonsson, US; Smith, P; Smythe, W	1
Amukoye, E; Bah, B; de Jong, BC; Fielding, K; Gninafon, M; Horton, J; Kassa, F; Lapujade, O; Lienhardt, C; Lo, MB; Merle, CS; Mthiyane, T; N'Diaye, A; Odhiambo, J; Olliaro, PL; Perronne, C; Rustomjee, R; Sismanidis, C; Sow, OB	1
Abena Foe, JL; Aït-Khaled, N; Kuaban, C; Noeske, J; Rieder, HL; Trébucq, A	1
Alvarez-Uria, G; Midde, M	1
Chen, H; Chen, N; Huang, C; Li, Y; Nie, Q; Tang, Q; Tao, L; Wang, X; Wang, Y; Yang, C; Zhou, Y	1

Reviews

5 review(s) available for gatifloxacin and isoniazid

Article	Year
Tuberculosis: the drug development pipeline at a glance. European journal of medicinal chemistry, 2012, Volume: 51 Topics: Animals; Antitubercular Agents; Clinical Trials as Topic; Drug Discovery; Humans; Tuberculosis	2012
Isoniazid derivatives and their anti-tubercular activity. European journal of medicinal chemistry, 2017, Jun-16, Volume: 133 Topics: Animals; Antitubercular Agents; Drug Discovery; Humans; Isoniazid; Mycobacterium tuberculosis; Tuberculosis; Tuberculosis, Multidrug-Resistant	2017
Fluoroquinolone derivatives and their anti-tubercular activities. European journal of medicinal chemistry, 2018, Feb-25, Volume: 146 Topics: Animals; Antitubercular Agents; Dose-Response Relationship, Drug; Fluoroquinolones; Humans; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Tuberculosis	2018
Fluoroquinolone-isatin hybrids and their biological activities. European journal of medicinal chemistry, 2019, Jan-15, Volume: 162 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Antitubercular Agents; Antiviral Agents; Fluoroquinolones; Humans; Isatin; Structure-Activity Relationship	2019
An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review. European journal of medicinal chemistry, 2021, Jan-15, Volume: 210 Topics: Animals; Antitubercular Agents; Drug Design; Drug Discovery; Humans; Mycobacterium tuberculosis; Piperazine; Structure-Activity Relationship; Tuberculosis	2021

Trials

5 trial(s) available for gatifloxacin and isoniazid

Article	Year
Short-course treatment regimen to identify potential antituberculous agents in a murine model of tuberculosis. The Journal of antimicrobial chemotherapy, 2004, Volume: 53, Issue:4 Topics: Acetamides; Animals; Antitubercular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Gatifloxacin; Isoniazid; Linezolid; Mice; Mice, Inbred C57BL; Oxazolidinones; Rifampin; Time Factors; Tuberculosis	2004
A Phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2008, Volume: 12, Issue:2 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Antitubercular Agents; Aza Compounds; Colony Count, Microbial; Drug Therapy, Combination; Female; Fluoroquinolones; Gatifloxacin; Humans; Isoniazid; Male; Middle Aged; Moxifloxacin; Nonlinear Dynamics; Ofloxacin; Pyrazinamide; Quinolines; Rifampin; Sputum	2008
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:7 Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; Gatifloxacin; Humans; Injections, Intramuscular; Isoniazid; Levofloxacin; Male; Middle Aged; Multivariate Analysis; Ofloxacin; Pyrazinamide; Rifampin; Streptomycin; Tuberculosis, Meningeal; Young Adult	2011
Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:9 Topics: Adult; Antitubercular Agents; Area Under Curve; Coinfection; Drug Administration Schedule; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Female; Fluoroquinolones; Gatifloxacin; HIV Infections; Humans; Isoniazid; Male; Monte Carlo Method; Pyrazinamide; Rifampin; Tuberculosis, Pulmonary	2013
A four-month gatifloxacin-containing regimen for treating tuberculosis. The New England journal of medicine, 2014, Oct-23, Volume: 371, Issue:17 Topics: Adult; Antitubercular Agents; Blood Glucose; Drug Administration Schedule; Drug Therapy, Combination; Ethambutol; Female; Fluoroquinolones; Gatifloxacin; Humans; Intention to Treat Analysis; Isoniazid; Male; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Tuberculosis, Pulmonary	2014

Other Studies

26 other study(ies) available for gatifloxacin and isoniazid

Article	Year
Discovery of new antitubercular oxazolyl thiosemicarbazones. Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12 Topics: Antibiotics, Antitubercular; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiosemicarbazones	2006
An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles. Bioorganic & medicinal chemistry letters, 2007, Dec-01, Volume: 17, Issue:23 Topics: Anti-Bacterial Agents; Catalysis; Drug Evaluation, Preclinical; Humans; Microbial Sensitivity Tests; Mycobacterium smegmatis; Nitriles; Pyridines; Solvents	2007
Antimycobacterial activities of novel 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acid. Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24 Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Drug Resistance, Multiple, Bacterial; Female; Light; Mice; Microbial Sensitivity Tests; Mycobacterium smegmatis; Mycobacterium tuberculosis; Naphthyridines; Structure-Activity Relationship; Topoisomerase II Inhibitors; Vero Cells	2007
Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids. Bioorganic & medicinal chemistry, 2008, Mar-01, Volume: 16, Issue:5 Topics: Amination; Animals; Anti-Bacterial Agents; Cell Survival; Chlorocebus aethiops; Cyclopropanes; DNA Gyrase; Fluorine Compounds; Hydroxyquinolines; Molecular Structure; Mycobacterium; Photosensitizing Agents; Structure-Activity Relationship; Topoisomerase II Inhibitors; Vero Cells	2008
Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Animals; Antitubercular Agents; Biological Availability; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyridones; Quinolones; Treatment Outcome; Tuberculosis, Pulmonary	2008
Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid. Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6 Topics: Animals; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Lung; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium smegmatis; Mycobacterium tuberculosis; Quinolines; Spleen; Structure-Activity Relationship	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids. European journal of medicinal chemistry, 2009, Volume: 44, Issue:1 Topics: Animals; Anti-Bacterial Agents; Carboxylic Acids; Chlorocebus aethiops; DNA Gyrase; Lung Diseases; Mice; Microbial Sensitivity Tests; Mycobacterium smegmatis; Mycobacterium tuberculosis; Quinolines; Splenic Diseases; Structure-Activity Relationship; Vero Cells	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8 Topics: Antitubercular Agents; DNA Gyrase; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Quinolones; Thiazoles; Topoisomerase II Inhibitors; Tuberculosis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Animals; Antitubercular Agents; Cell Survival; Chlorocebus aethiops; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Female; Isatin; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Molecular Structure; Moxifloxacin; Mycobacterium tuberculosis; Structure-Activity Relationship; Triazoles; Vero Cells	2019
In vitro and in vivo activities of gatifloxacin against Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:4 Topics: Animals; Anti-Infective Agents; Antitubercular Agents; Aza Compounds; Colony Count, Microbial; Drug Combinations; Female; Fluoroquinolones; Gatifloxacin; Humans; Isoniazid; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium tuberculosis; Nasal Cavity; Quinolines; Tuberculosis	2002
Bactericidal action of gatifloxacin, rifampin, and isoniazid on logarithmic- and stationary-phase cultures of Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:2 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Fluoroquinolones; Gatifloxacin; Isoniazid; Mycobacterium tuberculosis; Rifampin	2005
Moxifloxacin and gatifloxacin in an acid model of persistent Mycobacterium tuberculosis. Journal of chemotherapy (Florence, Italy), 2006, Volume: 18, Issue:6 Topics: Antitubercular Agents; Aza Compounds; Colony Count, Microbial; Drug Synergism; Fluoroquinolones; Gatifloxacin; Hydrogen-Ion Concentration; Isoniazid; Moxifloxacin; Mycobacterium tuberculosis; Pyrazinamide; Quinolines; Rifampin; Time Factors	2006
Gatifloxacin in combination with rifampicin in a murine tuberculosis model. The Journal of antimicrobial chemotherapy, 2007, Volume: 60, Issue:2 Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Drug Combinations; Female; Fluoroquinolones; Gatifloxacin; Isoniazid; Lung; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Rifampin; Tuberculosis	2007
Elevated gatifloxacin and reduced rifampicin concentrations in a single-dose interaction study amongst healthy volunteers. The Journal of antimicrobial chemotherapy, 2007, Volume: 60, Issue:6 Topics: Aged; Antibiotics, Antitubercular; Area Under Curve; Cross-Over Studies; Drug Interactions; Female; Fluoroquinolones; Gatifloxacin; Humans; Isoniazid; Male; Middle Aged; Pyrazinamide; Rifampin	2007
Cerebral vacuolation induced in rats by the administration of LUP-3FDC, an anti-tuberculosis cocktail. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008, Volume: 59, Issue:6 Topics: Administration, Oral; Animals; Antitubercular Agents; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluoroquinolones; Gatifloxacin; Isoniazid; Male; Microscopy, Electron; Pyrazinamide; Rats; Rats, Wistar; Rifampin; Toxicity Tests, Chronic; Ultrasonography; Vacuoles	2008
A short-term model for preliminary screening of potential anti-tubercular compounds. Scandinavian journal of infectious diseases, 2009, Volume: 41, Issue:11-12 Topics: Animals; Antitubercular Agents; Colony Count, Microbial; Disease Models, Animal; Drug Discovery; Female; Fluoroquinolones; Gatifloxacin; Isoniazid; Lung; Male; Mice; Mycobacterium Infections; Mycobacterium smegmatis; Mycobacterium tuberculosis; Rifampin; Spleen	2009
Simultaneous determination of isoniazid, rifampicin, levofloxacin in mouse tissues and plasma by high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Aug-15, Volume: 878, Issue:24 Topics: Animals; Antibiotics, Antitubercular; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Fluoroquinolones; Gatifloxacin; Intestine, Small; Isoniazid; Kidney; Least-Squares Analysis; Levofloxacin; Liver; Lung; Male; Methanol; Mice; Ofloxacin; Reproducibility of Results; Rifampin; Sensitivity and Specificity; Tandem Mass Spectrometry; Tissue Distribution	2010
High effectiveness of a 12-month regimen for MDR-TB patients in Cameroon. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015, Volume: 19, Issue:5 Topics: Adolescent; Adult; Aged; Antitubercular Agents; Cameroon; Clofazimine; Cohort Studies; Confidence Intervals; Developing Countries; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Female; Fluoroquinolones; Gatifloxacin; Humans; Isoniazid; Kanamycin; Male; Medication Adherence; Middle Aged; Odds Ratio; Prospective Studies; Prothionamide; Pyrazinamide; Risk Assessment; Time Factors; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult	2015
Sex differences and factors influencing the duration of the QT interval in patients on anti-tuberculosis therapy. The European respiratory journal, 2018, Volume: 51, Issue:2 Topics: Antitubercular Agents; Clinical Trials as Topic; Electrocardiography; Ethambutol; Female; Gatifloxacin; Heart Rate; Humans; Isoniazid; Male; Models, Theoretical; Multivariate Analysis; Pyrazinamide; Rifampin; Sex Factors; Tuberculosis	2018
High-dose gatifloxacin-based shorter treatment regimens for MDR/RR-TB. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022, Volume: 115 Topics: Antitubercular Agents; Gatifloxacin; Humans; Isoniazid; Pyrazinamide; Treatment Outcome; Tuberculosis, Multidrug-Resistant	2022