gastrins and trimoprostil

The effect of varying oral doses of 11R, 16, 16-trimethyl prostaglandin E2 (TmPGE2) on meal-stimulated gastric acid secretion and serum gastrin concentrations was studied in 10 male subjects with asymptomatic duodenal ulcer disease. A liquid protein meal was infused intragastrically 0.5 h and 3.5 h after drug administration. TmPGE2 inhibited gastric acid secretion in a dose dependent manner during the first meal and no significant effect was observed during the second meal. Except for the highest dose, no TmPGE2 was detected in plasma 3 h after drug administration. The degree of inhibition of meal-stimulated gastric acid was positively correlated with the plasma level of TmPGE2, but it was not due to inhibition of postprandial gastrin release. The results indicate that oral TmPGE2 inhibits meal-stimulated gastric acid secretion but not gastrin release in humans with asymptomatic duodenal ulcer disease.

Topics: Adult; Aged; Analysis of Variance; Dinoprostone; Duodenal Ulcer; Food; Gastric Acid; Gastric Mucosa; Gastrins; Humans; Male; Middle Aged; Prostaglandins E, Synthetic; Random Allocation

The effect of trimoprostil, an analogue of prostaglandin E2, on gastric secretion was studied in healthy volunteers in comparison with that of cimetidine. Graded doses of 50, 250, 500 and 750 micrograms were given p.o. for trimoprostil and 200 mg for cimetidine. Basal secretion was significantly depressed at doses larger than 500 micrograms of trimoprostil but not by 200 mg of cimetidine probably due to the method of gastric analysis adopted in the study. In amyl-oxy-carbonyl (AOC)-tetragastrin stimulated gastric secretion, 500 micrograms of trimoprostil depressed acid output significantly, but did not affect pepsin output which was depressed, however, at 750 micrograms. On the other hand cimetidine markedly inhibited AOC-tetragastrin stimulated acid and pepsin secretion. Some difference was also recognized between trimoprostil and cimetidine concerning the mechanism of inhibitory action. Serum concentration of trimoprostil measured at 60 min after oral administration varied dose-dependently and antisecretory effects were also found to be dose-related. Serum gastrin and pepsinogen I were not affected either by trimoprostil or cimetidine. These results indicate that trimoprostil showed inhibitory effect on gastric secretion at doses larger than 500 micrograms for acid, and at doses larger than 750 micrograms for pepsin.

Topics: Adult; Anti-Ulcer Agents; Cimetidine; Dinoprostone; Female; Gastric Acid; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Gastrins; Humans; Male; Pepsin A; Pepsinogens