gastrins and bromopride

It has been shown that bromopride (Viaben) stimulates esophageal and gastric motility but no information exists regarding its effect on gastric acid secretion. The current study investigates the effect of bromopride on the basal and cephalic phase of gastric acid secretion and on serum gastrin levels. Studies were performed in 10 healthy volunteers using a standard aspiration technique. Following the collection of basal acid secretion all subjects received an i.v. injection of 10 mg bromopride or placebo in randomised order. 1 h after drug injection sham feeding was performed while gastric acid was continuously collected and repeated blood samples were drawn for serum gastrin determination. Neither basal secretion nor the cephalic phase of gastric acid secretion were altered by bromopride. Though secretion tended to be less following drug injection, none of these differences reached statistical significance. In addition serum gastrin levels remained unchanged following drug injection. The results of this study suggest that bromopride does not alter gastric acid secretion.

Topics: Adult; Female; Gastric Acid; Gastrins; Gastrointestinal Agents; Humans; Male; Metoclopramide; Time Factors