gastrin-heptadecapeptide--leu(15)- and gastrin-17

gastrin-heptadecapeptide--leu(15)- has been researched along with gastrin-17* in 1 studies

Other Studies

1 other study(ies) available for gastrin-heptadecapeptide--leu(15)- and gastrin-17

ArticleYear
[Syntheses of human little gastrin-I and its leucine-15, norleucine-15 and methoxinine-15 analogs].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1983, Volume: 364, Issue:2

    Human little gastrin-I is known to exhibit a high tendency to air-oxidation of its methionine-15 residue to the corresponding S-oxide derivative, with concomitant loss of biological activity. Since its leucine-15 analog, even if fully biologically active, differs significantly from the parent hormone in the immunological properties, the norleucine-15 and methoxinine-15 analogues were synthetized. For the required comparative analyses new syntheses of human little gastrin-I and of its leucine-15 analog were additionally elaborated. Upon an optimized condensation of the fragments, followed by the deprotection step, partition chromatography as well as preparative high-performance liquid chromatography led to the desired gastrins in satisfactory yields and high degree of purity as judged by the expected and known side products.

    Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Gastrins; Homoserine; Hormones; Humans; Magnetic Resonance Spectroscopy

1983