Page last updated: 2024-09-03

garenoxacin and moxifloxacin

garenoxacin has been researched along with moxifloxacin in 27 studies

Compound Research Comparison

Studies (garenoxacin)	Trials (garenoxacin)	Recent Studies (post-2010) (garenoxacin)	Studies (moxifloxacin)	Trials (moxifloxacin)	Recent Studies (post-2010) (moxifloxacin)
195	19	46	3,157	552	1,690

Protein Interaction Comparison

Protein	Taxonomy	moxifloxacin (IC50)
DNA gyrase subunit B	Staphylococcus aureus	5.1033
DNA gyrase subunit A	Escherichia coli K-12	1.4
DNA gyrase subunit B	Escherichia coli K-12	1.4
DNA topoisomerase 4 subunit A	Staphylococcus aureus	0.8
DNA gyrase subunit A	Staphylococcus aureus	7.25
DNA gyrase subunit B	Mycobacterium tuberculosis H37Rv	8.525
DNA gyrase subunit A	Mycobacterium tuberculosis H37Rv	8.66

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	20 (74.07)	29.6817
2010's	6 (22.22)	24.3611
2020's	1 (3.70)	2.80

Authors

Authors	Studies
Aubry, A; Cambau, E; Jarlier, V; Matrat, S; Petrella, S; Sougakoff, W	1
Aubry, A; Cambau, E; Jarlier, V; Matrat, S	1
Daw-Garza, A; Lozano-Garza, HG; Ocampo-Candiani, J; Rocha, NC; Said-Fernández, S; Vera-Cabrera, L; Waksman de Torres, N; Welsh, O	1
Ho, YR; Hung, KH; Janapatla, RP; Wu, CW; Wu, HM; Wu, JJ; Yan, JJ	1
Hirakata, Y; Imamura, Y; Izumikawa, K; Kakeya, H; Kamihira, S; Kohno, S; Seki, M; Sugahara, K; Yamamoto, K; Yamamoto, Y; Yanagihara, K	1
Inagaki, H; Ito, M; Kawakami, K; Matsuhashi, N; Miyauchi, R; Ohki, H; Takahashi, H; Takemura, M	1
Inagaki, H; Kitamura, T; Komoriya, S; Kuroyanagi, J; Miyauchi, RN; Nagamochi, M; Odagiri, T; Sugimoto, Y; Takahashi, H	1
Inagaki, H; Kitamura, T; Komoriya, S; Nagamochi, M; Odagiri, T; Takahashi, H	1
Blaskovich, MAT; Pham, TDM; Ziora, ZM	1
Brady, SF; Koirala, B; Peek, J	1
Biedenbach, DJ; Jones, RN; Pfaller, MA	1
Andrews, JM; Boswell, FJ; Wise, R	1
Barrett, JF; Chaniewski, S; Frosco, M; Hooper, DC; Lawrence, LE; Ryan, B; Yang, H	1
Appelbaum, PC; Bozdogan, B; Clark, CL; Davies, TA; Dewasse, B; Jacobs, MR; Nagai, K	1
Goldstein, EJ	1
Finegold, S; Goldstein, E; Gorbach, SL; Harrell, L; Hecht, DW; Jacobus, NV; Jenkins, S; McDermott, LA; Pierson, C; Rihs, J; Ruthazer, R; Snydman, DR; Venezia, R	1
Barton, T; Bowlware, K; Hardy, RD; Iglehart, J; Katz, K; McCoig, CC; McCracken, GH; Michelow, IC; Rodriguez-Cerrato, V; Saavedra, J	1
Ameyama, S; Shinmura, Y; Takahata, M	1
Piddock, L; Ricci, V	1
Barcia-Macay, M; Mingeot-Leclercq, MP; Seral, C; Tulkens, PM; Van Bambeke, F	1
Michot, JM; Mingeot-Leclercq, MP; Seral, C; Tulkens, PM; Van Bambeke, F	1
Almassi, GH; Brown, KR; Edmiston, CE; Kehl, KS; Krepel, CJ; Lewis, BD; Loehrl, TA; Seabrook, GR; Smith, TL; Somberg, LB; Towne, JB	1
Gidoh, M	1
Hoban, DJ; Noreddin, AM; Ostroski, M; Reese, AA; Zhanel, GG	1
Baba, S; Fujisawa, T; Harabuchi, Y; Ikeda, F; Kobayashi, T; Kurono, Y; Nishimura, T; Suzuki, K; Ubukata, K; Yamanaka, N	1
Aubry, A; Chauffour, A; Escolano, S; Henquet, S; Jarlier, V; Matsuoka, M; Veziris, N	1
Asano, Y; Kashiwagi, S; Nagayama, K; Noda, S; Ogawa, K; Ohira, M; Onoda, N; Takahashi, K; Takahashi, M; Takashima, T	1

Reviews

1 review(s) available for garenoxacin and moxifloxacin

Article	Year
Quinolone antibiotics. MedChemComm, 2019, Oct-01, Volume: 10, Issue:10 Topics:	2019

Other Studies

26 other study(ies) available for garenoxacin and moxifloxacin

Article	Year
Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:5 Topics: Anti-Infective Agents; DNA; DNA Gyrase; DNA, Superhelical; Enzyme Inhibitors; Mycobacterium leprae; Quinolones; Topoisomerase II Inhibitors	2007
Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones? Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Anti-Infective Agents; DNA Gyrase; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Mutation; Mycobacterium leprae	2008
In vivo therapeutic effect of gatifloxacin on BALB/c mice infected with Nocardia brasiliensis. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Female; Fluoroquinolones; Gatifloxacin; Humans; Linezolid; Mice; Mice, Inbred BALB C; Nocardia; Nocardia Infections; Oxazolidinones; Treatment Outcome	2008
Emergence of fluoroquinolone resistance in group B streptococcal isolates in Taiwan. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Bacterial Proteins; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Mutation; Ofloxacin; Streptococcus agalactiae; Taiwan	2008
In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8 Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerases; Drug Resistance, Bacterial; Fluoroquinolones; Microbial Sensitivity Tests; Mutation; Streptococcus pneumoniae	2009
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Anti-Bacterial Agents; Drug Design; Drug Resistance, Multiple; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinolones; Structure-Activity Relationship	2009
Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens. Journal of medicinal chemistry, 2013, Mar-14, Volume: 56, Issue:5 Topics: Animals; Anti-Bacterial Agents; Drug Design; Fluoroquinolones; Haemophilus influenzae; Male; Mice; Microbial Sensitivity Tests; Quinolones; Rats; Respiratory Tract Infections; Spiro Compounds; Staphylococcus aureus; Streptococcus pneumoniae	2013
Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens. Journal of medicinal chemistry, 2018, 08-23, Volume: 61, Issue:16 Topics: Animals; Anti-Bacterial Agents; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Bacterial; ERG1 Potassium Channel; Escherichia coli; Female; Humans; Macaca fascicularis; Male; Methicillin-Resistant Staphylococcus aureus; Mice, Inbred CBA; Microbial Sensitivity Tests; Pneumococcal Infections; Quinolines; Respiratory Tract Infections; Streptococcus pneumoniae	2018
Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics. Bioorganic & medicinal chemistry letters, 2022, 02-01, Volume: 57 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Fluoroquinolones; HEK293 Cells; Humans; Microbial Sensitivity Tests; Rifamycins; Staphylococcus aureus	2022
Activity of BMS284756 against 2,681 recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis: Report from The SENTRY Antimicrobial Surveillance Program (2000) in Europe, Canada and the United States. Diagnostic microbiology and infectious disease, 2001, Volume: 39, Issue:4 Topics: Anti-Infective Agents; Aza Compounds; Canada; Ciprofloxacin; Europe; Fluoroquinolones; Gatifloxacin; Haemophilus influenzae; Humans; Indoles; Levofloxacin; Microbial Sensitivity Tests; Moraxella catarrhalis; Moxifloxacin; Ofloxacin; Quinolines; Quinolones; United States	2001
Comparison of the in vitro activities of BMS-284756 and four fluoroquinolones against Streptococcus pneumoniae. The Journal of antimicrobial chemotherapy, 2001, Volume: 48, Issue:3 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Fluoroquinolones; Humans; Indoles; Microbial Sensitivity Tests; Moxifloxacin; Norfloxacin; Quinolines; Quinolones; Streptococcus pneumoniae	2001
Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:1 Topics: Anti-Infective Agents; Aza Compounds; DNA Topoisomerases, Type I; Fluoroquinolones; Indoles; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Ofloxacin; Quinolines; Quinolones; Staphylococcus aureus	2002
Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2002, Volume: 8, Issue:6 Topics: Anti-Infective Agents; Aza Compounds; Biological Transport; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Humans; Indoles; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Quinolones; Streptococcus pneumoniae	2002
Intra-abdominal anaerobic infections: bacteriology and therapeutic potential of newer antimicrobial carbapenem, fluoroquinolone, and desfluoroquinolone therapeutic agents. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Sep-01, Volume: 35, Issue:Suppl 1 Topics: Abdominal Abscess; Anti-Bacterial Agents; Aza Compounds; Bacteremia; Bacteria, Anaerobic; Bacteroides fragilis; Bacteroides Infections; beta-Lactams; Carbapenems; Clinical Trials as Topic; Ertapenem; Fluoroquinolones; Gemifloxacin; Humans; Indoles; Lactams; Moxifloxacin; Naphthyridines; Quinolines; Quinolones	2002
In vitro activities of newer quinolones against bacteroides group organisms. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:10 Topics: Anti-Infective Agents; Aza Compounds; Bacteroides; Bacteroides fragilis; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Indoles; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Quinolines; Quinolones	2002
Garenoxacin (BMS-284756) and moxifloxacin in experimental meningitis caused by vancomycin-tolerant pneumococci. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:1 Topics: Animals; Anti-Infective Agents; Aza Compounds; Fluoroquinolones; Indoles; Male; Meningitis, Bacterial; Microbial Sensitivity Tests; Moxifloxacin; Quinolines; Quinolones; Rabbits; Streptococcus pneumoniae; Vancomycin; Vancomycin Resistance	2003
Inhibitory activities of quinolones against DNA gyrase of Chlamydia pneumoniae. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:7 Topics: Anti-Infective Agents; Aza Compounds; Chlamydophila pneumoniae; DNA Gyrase; Fluoroquinolones; Gatifloxacin; Genes, Bacterial; Indoles; Levofloxacin; Molecular Sequence Data; Moxifloxacin; Ofloxacin; Quinolines; Quinolones; Topoisomerase II Inhibitors	2003
Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones. The Journal of antimicrobial chemotherapy, 2003, Volume: 52, Issue:4 Topics: Aza Compounds; Bacteroides fragilis; Ciprofloxacin; Fluoroquinolones; Gatifloxacin; Levofloxacin; Membrane Transport Modulators; Membrane Transport Proteins; Microbial Sensitivity Tests; Moxifloxacin; Ofloxacin; Quinolines	2003
Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages. The Journal of antimicrobial chemotherapy, 2005, Volume: 55, Issue:4 Topics: Animals; Anti-Bacterial Agents; Aza Compounds; Cell Line, Tumor; Ciprofloxacin; Fluoroquinolones; Levofloxacin; Listeria monocytogenes; Macrophages; Microbial Sensitivity Tests; Moxifloxacin; Ofloxacin; Quinolines; Staphylococcus aureus; Time Factors	2005
Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:6 Topics: Anti-Infective Agents; Aza Compounds; Cell Line; Ciprofloxacin; Fluoroquinolones; Heat-Shock Response; Humans; Kinetics; Levofloxacin; Macrophages; Moxifloxacin; Ofloxacin; Quinolines; Quinolones	2005
Comparative in vitro antimicrobial activity of a novel quinolone, garenoxacin, against aerobic and anaerobic microbial isolates recovered from general, vascular, cardiothoracic and otolaryngologic surgical patients. The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:5 Topics: Anti-Bacterial Agents; Aza Compounds; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Fluoroquinolones; Humans; Imipenem; Metronidazole; Microbial Sensitivity Tests; Moxifloxacin; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Quinolines	2005
[In-vitro and in-vivo activities of moxifloxacin and garenoxacin against Mycobacterium leprae]. Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, 2007, Volume: 76, Issue:1 Topics: Animals; Anti-Infective Agents; Aza Compounds; Drug Resistance, Bacterial; Female; Fluoroquinolones; Gatifloxacin; Leprostatic Agents; Levofloxacin; Mice; Mice, Inbred BALB C; Mice, Nude; Moxifloxacin; Mycobacterium leprae; Ofloxacin; Quinolines; Rifampin	2007
Comparative pharmacodynamics of garenoxacin, gemifloxacin, and moxifloxacin in community-acquired pneumonia caused by Streptococcus pneumoniae: a Monte Carlo simulation analysis. Clinical therapeutics, 2007, Volume: 29, Issue:12 Topics: Anti-Bacterial Agents; Area Under Curve; Aza Compounds; Community-Acquired Infections; Fluoroquinolones; Gemifloxacin; Humans; Monte Carlo Method; Moxifloxacin; Naphthyridines; Pneumococcal Infections; Quinolines; Respiratory Mucosa	2007
[Mutant prevention concentrations of garenoxacin against Streptococcus pneumoniae isolates from otorhinolaryngological infections]. The Japanese journal of antibiotics, 2010, Volume: 63, Issue:4 Topics: Anti-Bacterial Agents; Aza Compounds; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Levofloxacin; Moxifloxacin; Mutation; Ofloxacin; Otorhinolaryngologic Diseases; Pneumococcal Infections; Quinolines; Streptococcus pneumoniae	2010
Resistance of M. leprae to quinolones: a question of relativity? PLoS neglected tropical diseases, 2013, Volume: 7, Issue:11 Topics: Animals; Drug Resistance, Multiple, Bacterial; Female; Fluoroquinolones; Leprosy; Mice; Moxifloxacin; Mycobacterium leprae; Quinolines; Quinolones	2013
Effectiveness and safety of the pre-prescription of garenoxacin in comparison to moxifloxacin for low-risk febrile neutropenia in breast cancer patients undergoing adjuvant and neoadjuvant chemotherapy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019, Volume: 27, Issue:8 Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemoprevention; Chemotherapy-Induced Febrile Neutropenia; Chemotherapy, Adjuvant; Female; Fluoroquinolones; Follow-Up Studies; Humans; Middle Aged; Moxifloxacin; Neoadjuvant Therapy; Off-Label Use; Prior Authorization; Retrospective Studies; Risk Factors; Treatment Outcome	2019