garcinone-e has been researched along with mangostin* in 2 studies
2 other study(ies) available for garcinone-e and mangostin
| Article | Year |
|---|---|
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.
Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay. Of these compounds, garcinone D (3), garcinone E (5), alpha-mangostin (8), and gamma-mangostin (9) exhibited dose-dependent inhibitory activity. In a follow-up cell-based assay using SK-BR-3 breast cancer cells that express high levels of aromatase, the most potent of these four xanthones was gamma-mangostin (9). Because xanthones may be consumed in substantial amounts from commercially available mangosteen products, the consequences of frequent intake of mangosteen botanical dietary supplements require further investigation to determine their possible role in breast cancer chemoprevention. Topics: Anticarcinogenic Agents; Aromatase Inhibitors; Dietary Supplements; Dose-Response Relationship, Drug; Garcinia mangostana; Molecular Structure; Xanthones | 2008 |
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis. Topics: Apoptosis; Blotting, Western; Garcinia; HL-60 Cells; Humans; Indonesia; Inhibitory Concentration 50; Leukemia; Molecular Structure; Plants, Medicinal; Stereoisomerism; Tumor Cells, Cultured; Xanthones | 2003 |