garcinoic-acid and tocotrienol--delta

garcinoic-acid has been researched along with tocotrienol--delta* in 2 studies

Other Studies

2 other study(ies) available for garcinoic-acid and tocotrienol--delta

Article	Year
A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β. Molecules (Basel, Switzerland), 2020, Dec-11, Volume: 25, Issue:24 Garcinoic acid has been identified as an inhibitor of DNA polymerase β (pol β). However, no structure-activity relationship (SAR) studies of garcinoic acid as a pol β inhibitor have been conducted, in part due to the lack of an efficient synthetic method for this natural product and its analogs. We developed an efficient semi-synthetic method for garcinoic acid and its analogs by starting from natural product δ-tocotrienol. Our preliminary SAR studies provided a valuable insight into future discovery of garcinoic acid-based pol β inhibitors. Topics: Benzopyrans; Biological Products; Chemistry Techniques, Synthetic; DNA Polymerase beta; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Phenol; Structure-Activity Relationship; Temperature; Vitamin E	2020
Configuration of the vitamin E analogue garcinoic acid extracted from Garcinia Kola seeds. Chirality, 2009, Volume: 21, Issue:5 Vitamin E derivatives bearing a carboxylic group have recently gained great attention because of their antitumoral properties. Garcinoic acid (trans-13'-carboxy-delta-tocotrienol) is a vitamin E analog extracted from Garcinia Kola seeds in which the carboxylic group is at the end of the aliphatic side chain and reported to be a racemate based on the optical rotation measurements. However, CD determination of a sample of the acid analyzed by us gave a positive peak at 208 nm, indicating that it is not a racemate. To assess the enantiomeric composition of garcinoic acid, it was thus transformed to alpha-tocopherol and analyzed by chiral HPLC on column OD-H. On the basis of the elution order of alpha-tocopherol stereoisomers, the garcinoic acid sample resulted to be enantiopure with R configuration at carbon 2 of the chroman ring. Moreover, in a preliminary test, the acid and some of its derivatives showed a marked antiproliferative effect on glioma C6 cancer cells. Topics: alpha-Tocopherol; Anticarcinogenic Agents; Antioxidants; Apoptosis; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Garcinia kola; Humans; Molecular Structure; Plant Extracts; Seeds; Stereoisomerism; Tocopherols; Vitamin E	2009

Article

Year

A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β.

Molecules (Basel, Switzerland), 2020, Dec-11, Volume: 25, Issue:24

Garcinoic acid has been identified as an inhibitor of DNA polymerase β (pol β). However, no structure-activity relationship (SAR) studies of garcinoic acid as a pol β inhibitor have been conducted, in part due to the lack of an efficient synthetic method for this natural product and its analogs. We developed an efficient semi-synthetic method for garcinoic acid and its analogs by starting from natural product δ-tocotrienol. Our preliminary SAR studies provided a valuable insight into future discovery of garcinoic acid-based pol β inhibitors.

Topics: Benzopyrans; Biological Products; Chemistry Techniques, Synthetic; DNA Polymerase beta; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Phenol; Structure-Activity Relationship; Temperature; Vitamin E

2020

Configuration of the vitamin E analogue garcinoic acid extracted from Garcinia Kola seeds.

Chirality, 2009, Volume: 21, Issue:5

Vitamin E derivatives bearing a carboxylic group have recently gained great attention because of their antitumoral properties. Garcinoic acid (trans-13'-carboxy-delta-tocotrienol) is a vitamin E analog extracted from Garcinia Kola seeds in which the carboxylic group is at the end of the aliphatic side chain and reported to be a racemate based on the optical rotation measurements. However, CD determination of a sample of the acid analyzed by us gave a positive peak at 208 nm, indicating that it is not a racemate. To assess the enantiomeric composition of garcinoic acid, it was thus transformed to alpha-tocopherol and analyzed by chiral HPLC on column OD-H. On the basis of the elution order of alpha-tocopherol stereoisomers, the garcinoic acid sample resulted to be enantiopure with R configuration at carbon 2 of the chroman ring. Moreover, in a preliminary test, the acid and some of its derivatives showed a marked antiproliferative effect on glioma C6 cancer cells.

Topics: alpha-Tocopherol; Anticarcinogenic Agents; Antioxidants; Apoptosis; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Garcinia kola; Humans; Molecular Structure; Plant Extracts; Seeds; Stereoisomerism; Tocopherols; Vitamin E

2009