ganoderic-acid and phosphatidylinositol-4-phosphate

How cells drive the phospholipid signal response to heat stress (HS) to maintain cellular homeostasis is a fundamental issue in biology, but the regulatory mechanism of this fundamental process is unclear. Previous quantitative analyses of lipids showed that phosphatidylinositol (PI) accumulates after HS in Ganoderma lucidum, implying the inositol phospholipid signal may be associated with HS signal transduction. Here, we found that the PI-4-kinase and PI-4-phosphate-5-kinase activities are activated and that their lipid products PI-4-phosphate and PI-4,5-bisphosphate are increased under HS. Further experimental results showed that the cytosolic Ca

Topics: Calcium; Cytosol; Heat-Shock Response; Homeostasis; Phosphatidylinositol Phosphates; Phosphatidylinositols; Reishi; Signal Transduction; Triterpenes