ganglioside--gd1a and trichloroacetamide

ganglioside--gd1a has been researched along with trichloroacetamide* in 1 studies

Other Studies

1 other study(ies) available for ganglioside--gd1a and trichloroacetamide

Article	Year
Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. Carbohydrate research, 2009, Aug-17, Volume: 344, Issue:12 A first systematic synthesis of the glycan parts of the a-series gangliosides (GT1a, GD1a, and GM1) utilizing the newly developed N-Troc-protected GM3 and galactosaminyl building blocks is described. The key processes, including the assembly of the GM2 sequence and its conversion into the 3-hydroxy acceptor, were facilitated mainly by the high degree of participation and chemoselective cleavability of the Troc group in the galactosaminyl unit. Furthermore, the novel GM2 acceptor served as a good coupling partner during glycosylation with galactosyl, sialyl galactosyl, and disialyl galactosyl donors, successfully producing the GM1, GD1a, and GT1a glycans. Topics: Acetamides; Carbohydrate Sequence; Chloroacetates; G(M1) Ganglioside; G(M3) Ganglioside; Gangliosides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Trichloroacetic Acid	2009

Article

Year

Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates.

Carbohydrate research, 2009, Aug-17, Volume: 344, Issue:12

A first systematic synthesis of the glycan parts of the a-series gangliosides (GT1a, GD1a, and GM1) utilizing the newly developed N-Troc-protected GM3 and galactosaminyl building blocks is described. The key processes, including the assembly of the GM2 sequence and its conversion into the 3-hydroxy acceptor, were facilitated mainly by the high degree of participation and chemoselective cleavability of the Troc group in the galactosaminyl unit. Furthermore, the novel GM2 acceptor served as a good coupling partner during glycosylation with galactosyl, sialyl galactosyl, and disialyl galactosyl donors, successfully producing the GM1, GD1a, and GT1a glycans.

Topics: Acetamides; Carbohydrate Sequence; Chloroacetates; G(M1) Ganglioside; G(M3) Ganglioside; Gangliosides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Trichloroacetic Acid

2009