ganglioside--gd1a and herbimycin

ganglioside--gd1a has been researched along with herbimycin* in 1 studies

Other Studies

1 other study(ies) available for ganglioside--gd1a and herbimycin

Article	Year
Gangliosides GD1a and GM3 induce interleukin-10 production by human T cells. Biochemical and biophysical research communications, 1999, Mar-05, Volume: 256, Issue:1 Gangliosides are sialic acid-containing glycosphingolipids and exhibit various physiologic functions. Gangliosides GD1a and GM3 strongly induced interleukin-10 (IL-10) protein secretion and mRNA expression in T cells from normal human subjects while the other gangliosides were ineffective. IL-10 induction by both gangliosides was completely blocked by protein tyrosine kinase (PTK) inhibitors, herbimycin A, genistein, and tyrphostin AG 1288, but not by other signal transduction inhibitors. These results suggest that GD1a and GM3 may induce IL-10 production in T cells by regulating the PTK-dependent signaling pathway. These gangliosides may thus act as important immunoregulators via IL-10. Topics: Benzoquinones; Cell Division; Cell Survival; Cells, Cultured; DNA; Dose-Response Relationship, Drug; G(M3) Ganglioside; Gangliosides; Humans; Interleukin-10; Isoquinolines; Lactams, Macrocyclic; Protein Kinase Inhibitors; Protein Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; Staurosporine; Sulfonamides; T-Lymphocytes; Time Factors; Transcriptional Activation	1999

Article

Year

Gangliosides GD1a and GM3 induce interleukin-10 production by human T cells.

Biochemical and biophysical research communications, 1999, Mar-05, Volume: 256, Issue:1

Gangliosides are sialic acid-containing glycosphingolipids and exhibit various physiologic functions. Gangliosides GD1a and GM3 strongly induced interleukin-10 (IL-10) protein secretion and mRNA expression in T cells from normal human subjects while the other gangliosides were ineffective. IL-10 induction by both gangliosides was completely blocked by protein tyrosine kinase (PTK) inhibitors, herbimycin A, genistein, and tyrphostin AG 1288, but not by other signal transduction inhibitors. These results suggest that GD1a and GM3 may induce IL-10 production in T cells by regulating the PTK-dependent signaling pathway. These gangliosides may thus act as important immunoregulators via IL-10.

Topics: Benzoquinones; Cell Division; Cell Survival; Cells, Cultured; DNA; Dose-Response Relationship, Drug; G(M3) Ganglioside; Gangliosides; Humans; Interleukin-10; Isoquinolines; Lactams, Macrocyclic; Protein Kinase Inhibitors; Protein Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; Staurosporine; Sulfonamides; T-Lymphocytes; Time Factors; Transcriptional Activation

1999