ganglioside--gd1a and dodecylphosphocholine

ganglioside--gd1a has been researched along with dodecylphosphocholine* in 1 studies

Other Studies

1 other study(ies) available for ganglioside--gd1a and dodecylphosphocholine

Article	Year
Carbohydrate dynamics at a micellar surface: GD1a headgroup transformations revealed by NMR spectroscopy. Biophysical journal, 1994, Volume: 66, Issue:5 The conformational dynamics of the carbohydrate headgroup of ganglioside GD1a, NeuAc alpha 2-->3Gal beta 1-->3GalNAc beta 1-->4[NeuAc alpha 2-->3]Gal beta 1-->4Glc beta 1-->1Cer, anchored in a perdeuterated dodecylphosphocholine micelle in aqueous solution, were probed by high resolution NMR spectroscopy. The observed 1H/1H NOE interactions revealed conformational averaging of the terminal NeuAc alpha 2-->3Gal and Gal beta 1-->3GalNAc glycosidic linkages. The pronounced flexibility of this trisaccharide moiety was substantiated further by two-dimensional proton-detected 13C T1, T1 rho and 1H/13C NOE measurements. The anchoring effect of the micelle allowed the detection of conformational fluctuations of the headgroup on the time scale of a few hundred picoseconds. NMR experiments performed on the GD1a/DPC micelles in H2O at low temperatures permitted the observation of hydroxyl proton resonances, contributing valuable conformational information. Topics: Animals; Biophysical Phenomena; Biophysics; Carbohydrate Conformation; Carbohydrate Sequence; Cattle; Gangliosides; In Vitro Techniques; Magnetic Resonance Spectroscopy; Micelles; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phosphorylcholine; Solutions; Thermodynamics; Water	1994

Article

Year

Carbohydrate dynamics at a micellar surface: GD1a headgroup transformations revealed by NMR spectroscopy.

Biophysical journal, 1994, Volume: 66, Issue:5

The conformational dynamics of the carbohydrate headgroup of ganglioside GD1a, NeuAc alpha 2-->3Gal beta 1-->3GalNAc beta 1-->4[NeuAc alpha 2-->3]Gal beta 1-->4Glc beta 1-->1Cer, anchored in a perdeuterated dodecylphosphocholine micelle in aqueous solution, were probed by high resolution NMR spectroscopy. The observed 1H/1H NOE interactions revealed conformational averaging of the terminal NeuAc alpha 2-->3Gal and Gal beta 1-->3GalNAc glycosidic linkages. The pronounced flexibility of this trisaccharide moiety was substantiated further by two-dimensional proton-detected 13C T1, T1 rho and 1H/13C NOE measurements. The anchoring effect of the micelle allowed the detection of conformational fluctuations of the headgroup on the time scale of a few hundred picoseconds. NMR experiments performed on the GD1a/DPC micelles in H2O at low temperatures permitted the observation of hydroxyl proton resonances, contributing valuable conformational information.

Topics: Animals; Biophysical Phenomena; Biophysics; Carbohydrate Conformation; Carbohydrate Sequence; Cattle; Gangliosides; In Vitro Techniques; Magnetic Resonance Spectroscopy; Micelles; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phosphorylcholine; Solutions; Thermodynamics; Water

1994