ganciclovir and pyrimidine

ganciclovir has been researched along with pyrimidine* in 2 studies

Other Studies

2 other study(ies) available for ganciclovir and pyrimidine

Article	Year
Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies. European journal of medicinal chemistry, 2013, Volume: 66 One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as AT rich pUC18 DNA. Topics: Antimalarials; Antiviral Agents; Cell Line; Chemistry Techniques, Synthetic; DNA; Heme; Humans; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship	2013
Discovery of a novel series of inhibitors of human cytomegalovirus primase. Bioorganic & medicinal chemistry letters, 2006, Sep-15, Volume: 16, Issue:18 Infection by human cytomegalovirus (hCMV) remains a potent threat to susceptible people throughout the world. We have discovered a series of imidazolyl-pyrimidine compounds, which were found to be irreversible inhibitors of the hCMV UL70 primase based on results from radiolabeling and SAR studies. Two promising analogs are described that rival ganciclovir and cidofovir in antiviral potency and possess improved cytotoxicity profiles. Topics: Antiviral Agents; Bone Marrow; Cell Line; Cytomegalovirus; DNA Primase; Enzyme Inhibitors; Humans; Molecular Structure; Pyrimidines; Structure-Activity Relationship	2006

Article

Year

Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.

European journal of medicinal chemistry, 2013, Volume: 66

One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as AT rich pUC18 DNA.

Topics: Antimalarials; Antiviral Agents; Cell Line; Chemistry Techniques, Synthetic; DNA; Heme; Humans; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship

2013

Discovery of a novel series of inhibitors of human cytomegalovirus primase.

Bioorganic & medicinal chemistry letters, 2006, Sep-15, Volume: 16, Issue:18

Infection by human cytomegalovirus (hCMV) remains a potent threat to susceptible people throughout the world. We have discovered a series of imidazolyl-pyrimidine compounds, which were found to be irreversible inhibitors of the hCMV UL70 primase based on results from radiolabeling and SAR studies. Two promising analogs are described that rival ganciclovir and cidofovir in antiviral potency and possess improved cytotoxicity profiles.

Topics: Antiviral Agents; Bone Marrow; Cell Line; Cytomegalovirus; DNA Primase; Enzyme Inhibitors; Humans; Molecular Structure; Pyrimidines; Structure-Activity Relationship

2006