ganciclovir has been researched along with aniline* in 1 studies
1 other study(ies) available for ganciclovir and aniline
| Article | Year |
|---|---|
Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: synthesis and activity against human cytomegalovirus.
2-Anilinopurines and 6-anilinopyrimidines bearing 3,4- or 3,5-dichloro substituents in the anilino ring inhibited virus-specific DNA synthesis by human cytomegalovirus (HCMV)-infected human embryonic lung (HEL) cells in culture. In general, active compounds had moderate to low selectivity for viral vs host cell DNA synthesis. Nucleoside and acyclonucleoside analogs of 2-(3,5-dichloroanilino)purines inhibited both HCMV and cellular DNA synthesis at similar concentrations. 2-Amino-4-chloro-6-(3,5-dichloroanilino)pyrimidine and several related compounds inhibited HCMV growth in yield reduction assays at concentrations that were nontoxic to HEL cells. Topics: Aniline Compounds; Antiviral Agents; Cell Division; Cell Line; Cytomegalovirus; DNA-Directed DNA Polymerase; Halogens; Humans; Purine Nucleosides; Purines; Pyrimidines; Virus Replication | 1995 |