ganciclovir and 9-((2-phosphonylmethoxy)ethyl)guanine

ganciclovir has been researched along with 9-((2-phosphonylmethoxy)ethyl)guanine* in 1 studies

Other Studies

1 other study(ies) available for ganciclovir and 9-((2-phosphonylmethoxy)ethyl)guanine

Article	Year
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16 A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti-human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'-methyl-PMEG [(R)-3] and 2',2'-dimethyl-PMEG (7) demonstrated potent anti-HIV activity in the XTT assay with EC50 values of 1.0 and 2.6 microM, respectively. The corresponding (S)-2'-methyl-PMEG [(S)-3] was found to be less potent against HIV. In addition, the (R) and (S) enantiomers of 9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine (HPMPG, 8) were prepared for comparison of biological activity, and shown to be active and equipotent against herpesviruses, but inactive against HIV. Topics: Antiviral Agents; Cell Line; Guanine; HIV; Microbial Sensitivity Tests; Organophosphorus Compounds; Simplexvirus; Stereoisomerism; Structure-Activity Relationship	1992

Article

Year

Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.

Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16

A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti-human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'-methyl-PMEG [(R)-3] and 2',2'-dimethyl-PMEG (7) demonstrated potent anti-HIV activity in the XTT assay with EC50 values of 1.0 and 2.6 microM, respectively. The corresponding (S)-2'-methyl-PMEG [(S)-3] was found to be less potent against HIV. In addition, the (R) and (S) enantiomers of 9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine (HPMPG, 8) were prepared for comparison of biological activity, and shown to be active and equipotent against herpesviruses, but inactive against HIV.

Topics: Antiviral Agents; Cell Line; Guanine; HIV; Microbial Sensitivity Tests; Organophosphorus Compounds; Simplexvirus; Stereoisomerism; Structure-Activity Relationship

1992