ganaxolone and 4-hydroxybutyric-acid

ganaxolone has been researched along with 4-hydroxybutyric-acid* in 1 studies

Other Studies

1 other study(ies) available for ganaxolone and 4-hydroxybutyric-acid

Article	Year
Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. Annals of neurology, 1998, Volume: 44, Issue:4 Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one) is a novel neurosteroid which has anticonvulsant properties in a number of seizure models as well as the ability to enhance function of the gamma-aminobutyric acid-A (GABA(A)) receptor complex via a neurosteroid binding site. The object of these experiments was to ascertain the efficacy of ganaxolone against absence seizures. Ganaxolone was assessed in the low-dose pentylenetetrazol (PTZ) and the gamma-hydroxybutyric acid (GHB) model of absence seizures in rats. Ganaxolone pretreatment resulted in a significant prolongation of absence seizure in both the PTZ and GHB models. Further, ganaxolone in doses above 20 mg/kg alone produced bilaterally synchronous spike wave discharges (SWDs) associated with behavioral arrest. These data suggest that augmentation of GABA(A) receptor complex function by neurosteroids has the potential to result in or exacerbate absence seizures. Topics: Animals; Anticonvulsants; Convulsants; Epilepsy, Absence; GABA Antagonists; Hydroxybutyrates; Male; Pentylenetetrazole; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A	1998

Article

Year

Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence.

Annals of neurology, 1998, Volume: 44, Issue:4

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one) is a novel neurosteroid which has anticonvulsant properties in a number of seizure models as well as the ability to enhance function of the gamma-aminobutyric acid-A (GABA(A)) receptor complex via a neurosteroid binding site. The object of these experiments was to ascertain the efficacy of ganaxolone against absence seizures. Ganaxolone was assessed in the low-dose pentylenetetrazol (PTZ) and the gamma-hydroxybutyric acid (GHB) model of absence seizures in rats. Ganaxolone pretreatment resulted in a significant prolongation of absence seizure in both the PTZ and GHB models. Further, ganaxolone in doses above 20 mg/kg alone produced bilaterally synchronous spike wave discharges (SWDs) associated with behavioral arrest. These data suggest that augmentation of GABA(A) receptor complex function by neurosteroids has the potential to result in or exacerbate absence seizures.

Topics: Animals; Anticonvulsants; Convulsants; Epilepsy, Absence; GABA Antagonists; Hydroxybutyrates; Male; Pentylenetetrazole; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

1998