gamma-sitosterol and uvaol

Phytochemical study of the aerial parts of Cassiaitalica Mill. (family: Fabaceae) growing in Saudi Arabia afforded one new cycloartane triterpene, named (22E)-3-β-hydroxycycloart-22-en-24-one (2), together with eight known compounds: β-sitosterol (1), uvaol (3), daucosterol (4), methyl 3,4-dihydroxybenzoate (5), emodin (6), 4-hydroxypheny-O-β-D-glucopyranoside (7), aloin (8) and rutin (9). The structure of the isolated compounds was determined by physical, chemical and spectral data (UV, IR, MS, 1D ((1)H, (13)C and DEPT) and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR), as well as by comparing with authentic samples. Compounds 3-5 and 7-9 were isolated for the first time from the plant. Compound 2 was evaluated for its cytotoxic activity against the L5178Y and PC12 cell lines. The total methanolic extract and compounds 5-9 exhibited free radical-scavenging activity using DPPH assay.

Topics: Algorithms; Animals; Biphenyl Compounds; Cassia; Free Radical Scavengers; Humans; Hydroxybenzoates; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Picrates; Rats; Saudi Arabia; Sitosterols; Triterpenes

To study the chemical components of Gentiana tizuensis distributed in Qinghai Province.. Chromatography and spectral analyses were used to isolate the constituents and elucidate their structure.. Four compounds were isolated and identified as uvaol, L-(+)-l-O-methyl-myo-inositol, ursolic acid,beta-sitosterol.. All these components were obtained from the plant for the first time.

Topics: Gentiana; Plants, Medicinal; Sitosterols; Triterpenes; Ursolic Acid