gamma-sitosterol and tephrosin

A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitosterol (6). The structure of the new compound was characterised by analyses of NMR (1D and 2D) and MS data, and chemical conversion. Tephrokaempferoside (1) had weak antibacterial activity against Klebsiella pneumoniae with an MIC value of 150 μg/mL.

Topics: Anti-Bacterial Agents; Betulinic Acid; Drug Evaluation, Preclinical; Glycosides; Kaempferols; Klebsiella pneumoniae; Magnetic Resonance Spectroscopy; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; Rotenone; Sitosterols; Tephrosia; Triterpenes