gamma-sitosterol and octacosane

To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.. The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice.. Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).. All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.

Topics: Alkanes; Animals; Flavonoids; Hypoxia; Mice; Phytochemicals; Plant Extracts; Saussurea; Sitosterols; Solvents

To study the chemical constituents of the flower buds of Daphne genkwa.. The constituents of petroleum ether and ethyl acetate-soluble portions were isolated and purified by means of chromatography, then they were identified by their physico-chemical characteristics and spectral features.. Ten compounds were isolated and identified as octacosane (1), dotriacontane (2), beta-sitosterol (3), 4', 7-dimethoxy-5-hydroxyflovone (4), aurantiamide acetate (5), genkwanin (6), luteolin (7), apigenin (8), 3'-hydroxygenkwanin (9) and daphnoretin (10).. Compound 1 and 2 are isolated from this plant for the first time.

Topics: Alkanes; Apigenin; Coumarins; Daphne; Diacetyl; Dipeptides; Flavones; Flowers; Luteolin; Molecular Structure; Plants, Medicinal; Sitosterols