gamma-sitosterol has been researched along with arabinogalactan* in 1 studies
1 other study(ies) available for gamma-sitosterol and arabinogalactan
| Article | Year |
|---|---|
The composition of cell wall skeleton and outermost lipids of Mycobacterium vaccae is modified by ethambutol treatment.
Ethambutol (EMB) is a first line drug in tuberculosis treatment inhibiting the biosynthesis of arabinogalactan, which is a component of the mycobacterial cell wall. The growth of Mycobacterium vaccae cells in the presence of EMB increases cell wall permeability, which was monitored by beta-sitosterol biotransformation. GC/MS and GLC/MS (gas chromatography/mass spectrometry) analysis revealed dramatic changes in the content of covalently bound mycolic acids and in molar ratio galactose (Gal) to arabinose (Ara) in the cell envelopes of EMB-treated cells. The detected variations in the compositions of fatty acids indicate that both the cell wall skeleton and outer layer (free lipids) are decomposed due to EMB treatment. Topics: Antitubercular Agents; Arabinose; Cell Membrane Permeability; Cell Wall Skeleton; Ethambutol; Galactans; Galactose; Gas Chromatography-Mass Spectrometry; Glycolipids; Mycobacterium; Mycolic Acids; Phospholipids; Polysaccharides, Bacterial; Sitosterols | 2008 |