gamma-sitosterol and 4-hydroxybenzoic-acid

Insulin secretion and GLUT4 expression are two critical events in glucose regulation. The receptors G-protein-coupled receptor 40 (GPR40) and peroxisome proliferator-activated receptor-gamma (PPAR

Topics: Animals; Cucurbita; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Liver Glycogen; Parabens; Plant Extracts; PPAR gamma; RNA, Messenger; Secretagogues; Sitosterols

To study the chemical constituents from Macaranga denticulata Root.. The chemical constituents were isolated and purified by silica-gel column chromatography and recrystallization, and their structures were identified by physicochemical properties and spectral data.. Nine compounds were isolated and identified as: gheddic acid (1), aleuritolic acid-3-acetate (2), β-sitosterol (3), stigmast-4-en-6β-ol-3 -one (4), 2α-hydroxyaleuritolic acid 3-p-hydroxybenzoate (5), scopoletin (6), daucosterol (7), 2, 6-dimethoxy-1,4-benzoquinone (8) and maslinic acid(9).. Compounds 1-9 are obtained from this plant for the first time.

Topics: Benzoquinones; Euphorbiaceae; Parabens; Phytochemicals; Plant Roots; Plants, Medicinal; Scopoletin; Sitosterols; Stigmasterol; Triterpenes

To study the chemical constituents of Asarum himalaicum, fifteen compounds were isolated from a 70% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and semi-preparative HPLC. By spectroscopic techniques including 1H NMR, 13C NMR, and HR-ESI-MS, these compounds were identified as 4-demethoxyaristolochic acid BII (1), aristolochic acid I (2), aristolochic acid Ia (3), 7-hydroxyaristolochic acid I (4), aristolochic acid IV (5), aristolic acid II (6), debilic acid (7), aristololactam I (8), 9-hydroxyaristololactam I (9), 7-methoxyaristololactam IV (10), (2S)-narigenin-5, 7-di-O-beta-D-pyranosylglucoside (11), 4-hydroxybenzoic acid (12), 3, 4-dihydroxybenzoic acid (13), 4-hydroxycinnamic acid (14), and beta-sitosterol (15). All of these compounds (1-15) were obtained from A. himalaicum for the first time. Among them, 1 was identified as a new compound, and compounds 3-6, 9, 12-14 were isolated from Asarum genus for the first time. Since the kidney toxicity of aristolochic acids and aristololactams has been reported, the result of this investigation suggests that it should be cautioned to use A. himalaicum as a medicine.

Topics: Aristolochic Acids; Asarum; Chromatography, High Pressure Liquid; Coumaric Acids; Hydroxybenzoates; Magnetic Resonance Spectroscopy; Molecular Structure; Parabens; Plants, Medicinal; Propionates; Sitosterols; Spectrometry, Mass, Electrospray Ionization

Paniculacin (1), a new coumarin derivative, has been isolated from the ethyl acetate soluble fraction of the ethanolic extract of Murraya paniculata along with umbelliferone, scopoletin, 4-hydroxybenzoic acid, trans-cinnamic acid, and β-sitosterol. Their structures were elucidated on the basis of spectral data.

Topics: Cinnamates; Coumarins; Molecular Structure; Murraya; Nuclear Magnetic Resonance, Biomolecular; Pakistan; Parabens; Scopoletin; Sitosterols

To study the chemical constituent from the antithrombus activity extract of Radix Aerio Fici Microcarpae.. The isolation and purification of the extract were conducted by means of silica gel column chromatography, polyamide column chromatography and recrytallization. The structures of these compounds were elucidated based on the physicochemical properties and spectroscopic analysis.. 7 compounds were isolated from the extract. They were identified as isovanillic acid (1), 4-hydroxybenzoic acid(2),3,4-dihydroxybenzoic acid (3), friedelane (4), alpha-amyrin acetate (5), lanosterol (6) and beta-sitosterol (7) .. Compound 3,4 and 7 are isolated from this plant for the first time.

Topics: Fibrinolytic Agents; Ficus; Hydroxybenzoates; Lanosterol; Molecular Structure; Oleanolic Acid; Parabens; Plant Roots; Sitosterols; Triterpenes; Vanillic Acid

To research the chemical constituents from Daphne tangutica.. Column chromatography with silica gel, ODS-C18, Sephadex LH-20 and re-crystallization were employed to isolate and purify the constituents. According to physical and chemical properties and spectral data to identify the structure of compounds.. Eight compounds were isolated and identified as palmitic acid (1), laurostearic acid(2), beta-sitosterol(3), 7-methoxy-8-hydroxycumarin(4), daphnetin(5), genkwanin(6), hydroxygenkwanin(7), p-hydroxybenzoic acid(8).. Compounds 1,2,7 and 8 are isolated from Daphne tangutica for the first time.

Topics: Daphne; Flavones; Flavonoids; Magnetic Resonance Spectroscopy; Palmitic Acid; Parabens; Plant Bark; Plants, Medicinal; Sitosterols