gamma-rubromycin and fluoroboric-acid

gamma-rubromycin has been researched along with fluoroboric-acid* in 1 studies

Other Studies

1 other study(ies) available for gamma-rubromycin and fluoroboric-acid

ArticleYear
A convergent total synthesis of the telomerase inhibitor (±)-γ-rubromycin.
    Angewandte Chemie (International ed. in English), 2014, Apr-22, Volume: 53, Issue:17

    The total synthesis of the human telomerase inhibitor γ-rubromycin in its racemic form was accomplished in 3.8 % overall yield. The key feature of this synthesis is an efficient acid-catalyzed spiroketalization for the construction of the spiroketal core. The required electronically well-balanced spiroketal precursor was obtained by the convergent assembly of a naphthyl-substituted aldehyde, an α-methoxyallyl-γ-silyl-substituted phosphonate as the central C3 building block, and a highly functionalized aryl Grignard reagent. Another key feature is the late-stage construction of the isocoumarin moiety and a simultaneous protodesilylation furnishing the known methyl aryl ether protected precursor of γ-rubromycin.

    Topics: Borates; Boron Compounds; Enzyme Inhibitors; Humans; Isocoumarins; Lewis Acids; Mesylates; Methylation; Molecular Structure; Quinones; Telomerase

2014
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