Compounds > gamma-carboline
Page last updated: 2024-09-03

gamma-carboline and memantine

gamma-carboline has been researched along with memantine in 2 studies

Compound Research Comparison

Studies
(gamma-carboline)		Trials
(gamma-carboline)		Recent Studies (post-2010)
(gamma-carboline)		Studies
(memantine)		Trials
(memantine)		Recent Studies (post-2010) (memantine)
440262,6843411,425

Protein Interaction Comparison

ProteinTaxonomygamma-carboline (IC50)memantine (IC50)
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)6
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)6
AcetylcholinesteraseHomo sapiens (human)0.0049
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.4167
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)6
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)1.4167
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)4.3212
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)3.662
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)5.31
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)1.5

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Authors

AuthorsStudies
Arndt, HD; Gaube, F; Raztsou, I; Robaa, D; Rohrbach, MM; Sager, H; Schätz, B; Schwarthoff, S; Tischer, N; Winckler, T1
Aksinenko, AY; Bachurin, SO; Boltneva, NP; Bovina, EV; Dubova, LG; Epishina, TA; Fisenko, VP; Gabrelyan, AV; Goreva, TV; Grigoriev, VV; Kovaleva, NV; Lushchekina, SV; Makhaeva, GF; Pushkareva, EA; Richardson, RJ; Rudakova, EV; Shevtsov, PN; Shevtsova, EF; Zamoyski, VL1

Other Studies

2 other study(ies) available for gamma-carboline and memantine

ArticleYear
Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.
    Bioorganic & medicinal chemistry, 2021, 09-15, Volume: 46

    Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Carbolines; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Phenothiazines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

2021
Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands.
    Molecules (Basel, Switzerland), 2021, Sep-11, Volume: 26, Issue:18

    Topics: Acetylcholinesterase; Amantadine; Animals; Butyrylcholinesterase; Carbolines; Carboxylesterase; Catalytic Domain; Cell Line; Cholinesterase Inhibitors; Horses; Humans; Kinetics; Ligands; Memantine; Mitochondrial Transmembrane Permeability-Driven Necrosis; Molecular Docking Simulation; Propidium; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Swine; Tubulin; Tubulin Modulators

2021