gallidermin has been researched along with lanthionine* in 2 studies
2 other study(ies) available for gallidermin and lanthionine
| Article | Year |
|---|---|
Comparative studies on the fermentative production of lantibiotics by staphylococci.
The production of the lanthionine-containing polypeptide antibiotics gallidermin from Staphylococcus gallinarum TU 3928 and pep 5 from S. epidermidis 5 is investigated with respect to regulation and stimulation of productivity by media components, optimization of both the media used and the fermentation process and is compared to the production of the lantibiotic epidermin from S. epidermidis TU 3298. Efficient methods for rapid quantification of lantibiotics, optimization of the media and a primary enrichment by adsorption chromatography are reported. Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Chromatography, Gel; Culture Media; Fermentation; Microbial Sensitivity Tests; Molecular Sequence Data; Peptide Biosynthesis; Peptides; Peptides, Cyclic; Staphylococcus; Staphylococcus epidermidis; Sulfides | 1990 |
Gallidermin: a new lanthionine-containing polypeptide antibiotic.
Gallidermin is a new member of the class of lanthionine-containing peptide antibiotics, which are summarized under the common name lantibiotics. The lantibiotic gallidermin is produced by Staphylococcus gallinarum (F16/P57) Tü3928, and it exhibits activities against the Propionibacteria, involved in acne disease. Gallidermin differs from the recently discovered tetracyclic 21-residue peptide antibiotic epidermin only in a Leu/Ile exchange in position 6. The isolation procedures for gallidermin included adsorption directly from the culture broth, ion-exchange chromatography of the amphiphilic and basic polypeptide followed by desalting, and final purification by reversed-phase HPLC. The structural elucidation of the polypeptide containing four thioether bridges involved mainly a combination of automated gas-phase sequencing, thermospray liquid chromatography/mass spectrometry and fast-atom-bombardment mass spectrometry. Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Gas Chromatography-Mass Spectrometry; Microbial Sensitivity Tests; Molecular Sequence Data; Peptides; Peptides, Cyclic; Staphylococcus; Sulfides | 1988 |