gallic acid has been researched along with leonurine in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.48) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (6.96) | 29.6817 |
| 2010's | 68 (59.13) | 24.3611 |
| 2020's | 35 (30.43) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, KF; Kong, YC; Lay, WP; Yeung, HW | 1 |
| Luo, SR | 1 |
| Hu, WY; Mo, RY; Shao, GX; Zhu, LL | 1 |
| Chen, CX; Kwan, CY | 1 |
| Horie, S; Murayama, T; Pang, S; Tsuchiya, S; Uchida, M; Watanabe, K | 1 |
| HAYASHI, Y | 1 |
| Chao, Z; Ma, LL; Zhou, XJ | 1 |
| Ju, Y; Wang, Z; Zhang, PL | 1 |
| Liu, XH; Xin, H; Zhu, YZ | 1 |
| Hou, AJ; Liu, XH; Xin, H; Zhu, YZ | 1 |
| Chen, Z; Li, X; Song, K; Wang, L | 1 |
| Chen, PF; Liu, XH; Pan, LL; Silva, RD; Zhu, YZ | 1 |
| Chen, PF; Liu, XH; Pan, LL; Zhu, YZ | 1 |
| Gong, Q; Liu, X; Pan, L; Zhu, Y | 1 |
| Gong, QH; Liu, XH; Pan, LL; Zhu, YZ | 1 |
| Liu, XH; Loh, KP; Qi, J; Tan, BK; Wei, BG; Zhu, YZ | 1 |
| Gu, X; Liu, C; Zhu, YZ | 1 |
| Hong, ZY; Liu, HR; Shi, XR; Zhang, YC; Zhu, YZ | 1 |
| Hong, ZY; Qi, J; Xin, H; Zhu, YZ | 1 |
| Gu, X; Guo, W; Kaium, MA; Liu, C; Shi, X; Zhu, YZ | 1 |
| Huang, H; Liu, X; Wen, D; Xin, H; Xu, Y; Zhang, Y; Zhu, YZ | 1 |
| Cai, W; Ma, G; Sha, X; Shi, X; Zheng, Y; Zhu, Q; Zhu, Y | 1 |
| Liu, XH; Pan, LL; Zhu, YZ | 1 |
| Chen, FH; Li, CW; Li, JP; Li, X; Lu, WG; Yuan, FL; Zhao, YQ | 1 |
| Gong, QH; Liu, XH; Pan, LL; Yang, HB; Zhu, YZ | 1 |
| Gong, Q; Liu, X; Pan, L; Wang, X; Zhu, YZ | 1 |
| Catapano, AL; Norata, GD | 1 |
| Guo, W; Liu, H; Wen, Y; Wu, J; Xiong, Q; Zhang, Y; Zhu, Y; Zou, Y | 1 |
| Cao, X; Dong, L; Du, Y; Ji, H; Ji, Y; Li, L; Li, S; Liu, H; Wang, C; Xing, Y; Zhang, X; Zhao, K | 1 |
| Cai, H; Gu, M; Huang, SY; Li, FP; Wang, WW; Xin, H; Zhang, XM; Zhu, YZ | 1 |
| Deng, HY; Gong, QH; Huang, GY; Liu, XH; Pan, LL; Wu, D; Xiong, QH; Zhu, YZ | 1 |
| Kuchta, K; Ortwein, J; Rauwald, HW | 1 |
| Li, B; Li, X; Wu, J | 1 |
| He, CH; Li, CW; Li, X; Lu, WG; Yuan, FL; Zhao, YQ | 1 |
| Cai, W; Ma, G; Tan, B; Yang, P; Zhang, J; Zhou, N; Zhu, Q; Zhu, Y | 1 |
| Cai, W; Liu, X; Tan, B; Yang, P; Zhang, J; Zheng, Y; Zhu, Q; Zhu, Y | 1 |
| Chen, M; Ren, X; Wu, Y; Xu, D | 1 |
| Hong, ZY; Shi, XR; Wu, TT; Zhu, K; Zhu, YZ | 1 |
| Cao, Y; Jiang, H; Song, X; Wang, T; Wang, W; Zhang, N; Zhang, Z | 1 |
| Huang, K; Huang, L; Lei, X; Peng, A; Wang, H; Yang, X; Zheng, L | 1 |
| Ding, Q; Lu, C; Lu, T; Sun, Y; Yuan, Y; Zhang, X | 1 |
| He, XL; Jiang, DL; Jin, C; Li, X; Su, Q; Xu, RS; Yuan, FL | 1 |
| Bo, Y; Cheng, H; Jia, Z; Li, F; Shen, W; Tan, J; Xu, C | 1 |
| Cai, MH; Guo, H; Mao, F; Yuan, HH; Zhang, L | 1 |
| Appel, K; Kuchta, K; Merten, A; Rauwald, HW; Rusch, C; Savtschenko, A | 1 |
| Hong, ZY; Wang, ZJ; Yu, SS; Zhu, YZ | 1 |
| Fujinaka, R; Ishikawa, H; Ishisaka, A; Juri, M; Kato, Y; Kitamoto, N; Nitta, Y; Yoshiki, Y | 1 |
| Gao, H; Gu, X; Yang, X; Zhu, YZ | 1 |
| Gao, J; Liu, C; Xu, X; Yang, Z; Yin, H; Zhang, T | 1 |
| Ávila, JM; da Silva, UF; Dalcol, II; Morel, AF; Mostardeiro, MA; Saldanha, GA; Zachow, LL | 1 |
| Liu, X; Nie, J | 1 |
| Jiang, Y; Li, N; Lin, C; Liu, M; Liu, Q; Pan, D; Xu, H; Xu, Q | 1 |
| Kim, JH; Kim, YH; Lee, GY; Lee, H; Lee, JS; Leem, HH | 1 |
| Liu, XH; Sun, DM; Wang, Y; Wang, ZJ; Wu, WJ; Xu, P; Zhang, QY; Zhu, YZ | 1 |
| Dai, Z; He, Y; Ma, SC; Wang, B; Yu, JD; Zhang, YM; Zhou, C | 1 |
| Chen, M; Ding, J; Ding, X; Du, R; Hu, G; Jia, M; Li, C; Lu, M; Zheng, Y | 1 |
| Chen, Q; Hu, H; Jiang, T; Li, H; Lv, YC; Ren, K; Yao, R; Zhao, GJ | 1 |
| Liu, X; Wu, W; Zhu, Q; Zhu, YZ | 1 |
| Guo, W; Lin, S; Wu, J; Zhu, Y | 1 |
| Feng, Y; Jin, H; Lou, Y; Mao, C; Wang, C; Wang, Q; Xu, H; Xu, T; Zhang, L; Zhang, Z | 1 |
| Chen, H; Duan, C; Liu, X; Liu, Y; Qiu, M; Tang, H; Wang, C; Yang, J; Zhang, F; Zhou, X | 1 |
| Jiang, X; Wei, F; Xu, L; Zhu, H | 1 |
| Chen, X; Dai, A; Deng, G; Huang, C; Jiang, K; Li, X; Wu, H; Yang, X | 1 |
| Han, D; Li, J; Liu, X; Ma, Y; Xu, J; Zhang, S | 1 |
| Ba, G; Fu, Q; Guo, R; Li, Y; Liu, S; Man, X; Mu, S; Yang, L; Zhou, L | 1 |
| Lei, Y; Yin, W | 1 |
| Cao, W; Chen, Z; Huang, Z; Li, Q; Liu, X; Qi, J; Wu, L; Xing, C; Yuan, Y; Zhang, B; Zhao, M; Zhu, J | 1 |
| Feng, ZH; Fu, X; Gong, LF; Hu, ZC; Li, XB; Ni, WF; Xuan, JW | 1 |
| Jia, W; Yang, D; Zhu, YZ | 1 |
| Gu, XL; Liu, G; Luo, Y; Shang, Y; Yang, L; Zhu, X | 1 |
| Khan, FU; Li, HX; Pan, WS; Qi-Li, FR; Qian, C; Xu, X; Zhang, L | 1 |
| Gu, Y; Huang, J; Huang, R; Jin, M; Li, Q; Wan, B; Xu, X; Zhang, Y | 1 |
| Cai, X; Fan, J; Lin, X; Liu, D; Liu, J; Liu, L; Liu, X; Meng, P; Su, W; Wang, Y; Yang, H; Zhu, Q | 1 |
| Gu, XL; Lian, K; Liu, G; Luo, Y; Qiao, Y; Shang, Y; Yang, L; Zhang, B; Zhu, X | 1 |
| Gong, LY; Kamara, MO; Ma, HY; Meng, FH; Sun, Q; Wang, L; Wen, YQ; Zhao, N | 1 |
| Li, D; Li, S; Ouyang, J; Peng, X; Tian, X; Wang, R; Yang, J; Yu, G; Zhao, Y | 1 |
| Du, M; Huang, X; Li, D; Li, Y; Lin, Y; Liu, X; Wang, L; Xu, C; Yu, M; Zhu, Y | 1 |
| Du, MR; Li, DJ; Li, YY; Lin, YK; Liu, XH; Wang, L; Yu, M; Zhu, YZ | 1 |
| Chen, YX; He, JN; Xie, YZ; Yang, Y; Zhang, C; Zhang, XJ | 1 |
| Hu, PF; Qian, J; Sun, FF | 1 |
| Gao, W; Jia, T; Lin, D; Tao, Z; Wu, H; Zhou, Z | 1 |
| Chen, F; Chen, P; Zhou, BH | 1 |
| Chen, C; Hu, N; Huang, W; Liang, X; Zhu, Z | 1 |
| Kim, JH; Lee, GY; Leem, HH | 1 |
| Chen, Y; Huang, Y; Huang, YJ; Li, MY; Li, ZM; Liang, K; Lin, G; Ning, K; Wang, MJ; Yang, BF; Yu, B; Zhang, YL; Zhu, L; Zhu, YC; Zhu, YZ | 1 |
| Ji, M; Leng, T; Li, X; Sun, Y; Tang, Y; Wang, L; Xu, T; Yang, M; Zhuang, T | 1 |
| Liu, J; Luo, S; Ma, F; Xu, S; Zhu, YZ | 1 |
| Li, J; Lin, M; Pan, C; Xu, W; Zhu, X | 1 |
| Hwang, JK; Kim, C; Lee, H; Lee, J | 1 |
| Guo, H; Jiang, H; Jin, ZL; Kim, NH; Liu, W; Luo, D; Yao, XR; Yuan, B; Zhang, JB; Zhang, MJ | 1 |
| Bai, M; Cui, J; Deng, R; Wang, W; Xu, W; Zhou, F | 1 |
| Chen, ZX; Chu, CQ; Du, YY; Lin, CS; Liu, MY; Liu, QP; Xu, Q | 1 |
| Li, X; Liu, Z; Ou, X; Qi, X; Qu, W; Wang, C; Wang, Y; Xie, Y; Zhu, L | 1 |
| Li, D; Li, G; Lv, D; Ouyang, J; Peng, L; Shang, F; Wang, R; Yan, J; Yang, J | 1 |
| Chen, YY; Huang, L; Tang, YP; Xu, DQ; Yue, SJ | 1 |
| Du, M; Li, X; Li, Y; Lin, Y; Liu, X; Wang, X; Yu, M; Zhu, Y | 1 |
| Zhao, Y; Zong, F | 1 |
| Gong, L; Li, Y; Liao, L; Peng, C; Xue, X; Zhou, M | 1 |
| Chen, XJ; Luo, YJ; Qiu, LN; Tan, YR | 1 |
| Jin, T; Jin, Z; Ruan, L; Zheng, X; Zhuang, Q | 1 |
| Cui, Y; Liao, J; Suguro, R; Yu, Y; Zhao, X; Zhu, YZ | 1 |
| Chen, G; Ren, L; Wang, J; Wei, J; Zhou, Y | 1 |
| Chen, A; Han, L; Liu, L; Wang, F | 1 |
| Bi, X; Chen, L; Ding, W; Lu, J; Sun, Q; Tong, Y; Zhang, Q | 1 |
| Gu, J; Huang, K; Li, G; Pan, J; Shen, J; Wang, F; Wu, F; Wu, X; Xu, K; Ye, C; Zhang, T; Zhu, Y | 1 |
| Ding, XL; Qian, HB; Xue, DJ; Yang, FM; Yuan, QQ; Zhu, YZ | 1 |
| Abdel-Bakky, MS; Mohamed, AA; Salama, SA | 1 |
| Chen, X; Pan, Y; Qi, L; Shi, C; Tang, M; Wang, H; Yang, B; Zha, Z | 1 |
| Ci, X; Hou, T; Hu, J; Peng, L; Yan, K | 1 |
| Ci, X; Fan, X; Gu, W; Hu, J; Ma, N | 1 |
| Du, MR; Li, DJ; Li, Y; Li, YY; Lin, YK; Liu, XH; Wang, L; Wang, XL; Yu, M; Zhu, YZ | 1 |
| Chen, Z; Ha, L; Hou, B; Huan, Z; Huang, S; Zhang, C | 1 |
| Peng, Q; Qi, S; Wang, D; Wang, R; Zhao, B; Zhou, R; Zhu, Y | 1 |
| Cheng, JJ; Du, MR; Li, DJ; Li, Y; Li, YY; Lin, YK; Wang, L; Wang, XL; Yu, M; Zhu, YZ | 1 |
| Deng, Z; Fan, K; Li, D; Li, J; Ma, Y; Tang, X; Wang, Y; Wu, S | 1 |
5 review(s) available for gallic acid and leonurine
| Article | Year |
|---|---|
Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases.
Topics: Animals; Cardiovascular Diseases; Drugs, Chinese Herbal; Flavonoids; Gallic Acid; Humans; Leonurus; Medicine, Chinese Traditional; Rutin | 2012 |
Discovery of Leonuri and therapeutical applications: From bench to bedside.
Topics: Animals; Apoptosis; Atherosclerosis; Drug Discovery; Gallic Acid; Humans; Leonurus; Medicine, Chinese Traditional; Neurodegenerative Diseases | 2018 |
Leonurine: From Gynecologic Medicine to Pleiotropic Agent.
Topics: Drugs, Chinese Herbal; Female; Gallic Acid; Genital Diseases, Female; Humans; Plant Extracts | 2020 |
Leonurine, a potential drug for the treatment of cardiovascular system and central nervous system diseases.
Topics: Cardiovascular System; Central Nervous System Diseases; Drugs, Chinese Herbal; Female; Gallic Acid; Humans; Leonurus | 2021 |
Oxidative Injury in Ischemic Stroke: A Focus on NADPH Oxidase 4.
Topics: Animals; Betulinic Acid; Brain Ischemia; Drug Therapy, Combination; Electroacupuncture; Gallic Acid; Humans; Ischemic Stroke; Molecular Targeted Therapy; NADPH Oxidase 4; Oxidative Stress; Pentacyclic Triterpenes; Reactive Oxygen Species; Signal Transduction; Treatment Outcome | 2022 |
1 trial(s) available for gallic acid and leonurine
| Article | Year |
|---|---|
Leonurine affected homocysteine-methionine metabolism based on metabolomics and gut microbiota studies of clinical trial samples.
Topics: Beijing; Double-Blind Method; Gallic Acid; Gastrointestinal Microbiome; Homocysteine; Humans; Metabolomics; Methionine | 2021 |
109 other study(ies) available for gallic acid and leonurine
| Article | Year |
|---|---|
The structure and biological effect of leonurine. A uterotonic principle from the Chinese drug, I-mu Ts'ao.
Topics: Alkaloids; China; Female; Gallic Acid; Guanidines; Muscle Tonus; Uterine Contraction | 1977 |
[Separation and determination of alkaloids of Leonurus sibiricus].
Topics: Age Factors; Gallic Acid; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plants, Medicinal; Proline; Species Specificity | 1985 |
[Synthesis of leonurine and syringic acid aminoesters].
Topics: Anticoagulants; Gallic Acid; Humans; Platelet Aggregation | 1984 |
Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Carotid Arteries; Dogs; Drug Interactions; Endothelium, Vascular; Gallic Acid; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Plant Extracts; Plants, Medicinal; Portal Vein; Potassium Chloride; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Enhancement of phenylephrine-induced contraction in the isolated rat aorta with endothelium by H2O-extract from an Oriental medicinal plant Leonuri herba.
Topics: Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Synergism; Drugs, Chinese Herbal; Endothelium, Vascular; Gallic Acid; Male; Phenylephrine; Rats; Rats, Wistar; Vasoconstriction; Vasoconstrictor Agents | 2001 |
[Studies on the ingredients of Leonurus sibiricus L. II. Structure of leonurine. (2)].
Topics: Alkaloids; Gallic Acid; Leonurus | 1962 |
[Determination of stachydrine and leonurine in Herba Leonuri by ion- pair reversed-phase high-performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gallic Acid; Leonurus; Proline | 2004 |
Effect of leonurine on the activity of creatine kinase.
Topics: Creatine Kinase; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gallic Acid; Molecular Structure; Time Factors | 2004 |
Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells.
Topics: Animals; Apoptosis; Benzimidazoles; Bisbenzimidazole; Calcium; Carbocyanines; Cardiotonic Agents; Cell Nucleus; Cell Survival; Cells, Cultured; Coloring Agents; Doxorubicin; Fluorescent Dyes; Gallic Acid; Heart Ventricles; Malondialdehyde; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Rats; Tetrazolium Salts; Thiazoles | 2009 |
Protective effects of leonurine in neonatal rat hypoxic cardiomyocytes and rat infarcted heart.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Gallic Acid; Myocardial Infarction; Myocytes, Cardiac; Rats | 2009 |
[Determination of leonurine in leonurus granule and extractum by UPLC].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gallic Acid; Leonurus | 2009 |
4-Guanidino-n-butyl syringate (Leonurine, SCM 198) protects H9c2 rat ventricular cells from hypoxia-induced apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cell Survival; Cytochromes c; Cytosol; Drugs, Chinese Herbal; Flow Cytometry; Gallic Acid; Heart Ventricles; Microscopy, Fluorescence; Mitochondria, Heart; Molecular Structure; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Superoxide Dismutase | 2009 |
Leonurine improves ischemia-induced myocardial injury through antioxidative activity.
Topics: Animals; Antioxidants; Base Sequence; bcl-2-Associated X Protein; Blotting, Western; Creatine Kinase; DNA Primers; Gallic Acid; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase | 2010 |
Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction.
Topics: Alkaloids; Angiogenic Proteins; Animals; Antioxidants; Apoptosis Regulatory Proteins; Biomarkers; Cardiotonic Agents; Cell Line; Gallic Acid; Gene Expression Regulation; Heart; Male; Myocardial Ischemia; Myocardium; Oxidative Stress; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2010 |
Antiapoptotic effect of novel compound from Herba leonuri - leonurine (SCM-198): a mechanism through inhibition of mitochondria dysfunction in H9c2 cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cell Survival; Cytochromes c; DNA Fragmentation; Gallic Acid; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Myocytes, Cardiac; Oxidative Stress; Peroxides; Phytotherapy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Reactive Oxygen Species | 2010 |
Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Brain; Gallic Acid; Glutathione Peroxidase; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Mitochondria; Models, Animal; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase | 2010 |
Synthesis and biological evaluation of novel leonurine-SPRC conjugate as cardioprotective agents.
Topics: Animals; Animals, Newborn; Apoptosis; Cardiotonic Agents; Cross-Linking Reagents; Cysteine; Gallic Acid; Hydrogen Sulfide; Hypoxia; Muscle Cells; Oxidative Stress; Rats | 2010 |
Neuroprotective effects of SCM198 on 6-hydroxydopamine-induced behavioral deficit in rats and cytotoxicity in neuronal SH-SY5Y cells.
Topics: Animals; Behavior, Animal; Cell Line, Tumor; Cell Survival; Gallic Acid; Humans; Leonurus; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2011 |
Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cytochromes c; Disease Models, Animal; Drugs, Chinese Herbal; Gallic Acid; In Situ Nick-End Labeling; Leonurus; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Neuroprotective Agents; Oxidative Stress; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury | 2010 |
Leonurine-cysteine analog conjugates as a new class of multifunctional anti-myocardial ischemia agent.
Topics: Animals; Animals, Newborn; Blotting, Western; Catalase; Cells, Cultured; Cysteine; Gallic Acid; Heart Ventricles; Magnetic Resonance Spectroscopy; Malondialdehyde; Mass Spectrometry; Myocardial Ischemia; Polymerase Chain Reaction; Rats; Superoxide Dismutase | 2011 |
Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-κB pathway in db/db mice.
Topics: Adipose Tissue, White; Animals; Anti-Inflammatory Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Gallic Acid; Hypoglycemic Agents; Inflammation Mediators; Leonurus; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B | 2012 |
Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats.
Topics: Animals; Arginine; Calibration; Cardiovascular Agents; Chromatography, High Pressure Liquid; Gallic Acid; Leonurus; Limit of Detection; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2012 |
Effects of leonurine hydrochloride on medically induced incomplete abortion in early pregnancy rats.
Topics: Abortifacient Agents, Nonsteroidal; Abortifacient Agents, Steroidal; Abortion, Incomplete; Abortion, Induced; Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Estradiol; Female; Gallic Acid; In Vitro Techniques; Mifepristone; Misoprostol; Organ Size; Pregnancy; Random Allocation; Rats; Rats, Sprague-Dawley; Uterine Contraction; Uterine Hemorrhage; Uterus | 2011 |
Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Chemokine CCL2; Cyclooxygenase 2; E-Selectin; Endothelium, Vascular; Gallic Acid; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Proteins; Inflammation; Intercellular Adhesion Molecule-1; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2012 |
Leonurine protects against tumor necrosis factor-α-mediated inflammation in human umbilical vein endothelial cells.
Topics: Cell Adhesion; Chemokine CCL2; Cyclooxygenase 2; Gallic Acid; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Kinase; Intercellular Adhesion Molecule-1; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Transcription Factor RelA; Tumor Necrosis Factor-alpha; U937 Cells; Vascular Cell Adhesion Molecule-1 | 2012 |
Leonurine: a new comer in the natural compounds affecting atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; Gallic Acid; Male | 2012 |
SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; Chemokine CCL2; Gallic Acid; Hypercholesterolemia; Intercellular Adhesion Molecule-1; Interleukin-6; Lipid Peroxidation; Lipids; Male; Rabbits; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2012 |
Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke.
Topics: Animals; bcl-2-Associated X Protein; Blotting, Western; Brain Injuries; Catalase; Disease Models, Animal; Gallic Acid; Immunohistochemistry; Ion Channels; Male; Malondialdehyde; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Proteins; Mitochondrial Uncoupling Proteins; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stroke; Superoxide Dismutase | 2012 |
Effects of Leonurine on L-type calcium channel in rat ventricular myocytes.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Drugs, Chinese Herbal; Gallic Acid; Heart; Heart Ventricles; Leonurus; Male; Myocardium; Potassium; Rats; Rats, Sprague-Dawley; Sodium | 2012 |
Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4.
Topics: Angiotensin II; Animals; Cells, Cultured; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Gallic Acid; Leonurus; Male; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction | 2013 |
Leonurus japonicus, Leonurus cardiaca, Leonotis leonurus: a novel HPLC study on the occurrence and content of the pharmacologically active guanidino derivative leonurine.
Topics: Calibration; Chromatography, High Pressure Liquid; Fruit; Gallic Acid; Leonurus; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Leaves; Reference Standards; Reproducibility of Results; Species Specificity; Spectrometry, Mass, Electrospray Ionization | 2012 |
Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Diphenhydramine; Gallic Acid; Leonurus; Limit of Detection; Male; Plant Extracts; Proline; Rats; Rats, Wistar; Sensitivity and Specificity; Tandem Mass Spectrometry | 2013 |
Effect of leonurine hydrochloride on endothelin and the endothelin receptor-mediated signal pathway in medically-induced incomplete abortion in rats.
Topics: Abortion, Induced; Animals; Calcium; Drug Evaluation, Preclinical; Endothelins; Female; Gallic Acid; Male; Myometrium; Nitric Oxide; Pregnancy; Protein Kinase C; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Type C Phospholipases; Up-Regulation; Uterine Contraction | 2013 |
Identification of UDP-glucuronosyltransferase isoforms responsible for leonurine glucuronidation in human liver and intestinal microsomes.
Topics: Gallic Acid; Glucuronides; Glucuronosyltransferase; Herbal Medicine; Humans; Intestines; Liver; Microsomes; Microsomes, Liver; Protein Isoforms; UDP-Glucuronosyltransferase 1A9 | 2014 |
Characterization of metabolites of leonurine (SCM-198) in rats after oral administration by liquid chromatography/tandem mass spectrometry and NMR spectrometry.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Gallic Acid; Glucuronic Acid; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2014 |
Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-κB signaling pathway.
Topics: Acute Kidney Injury; Animals; Gallic Acid; Glutathione; Kidney; Kidney Function Tests; Lipopolysaccharides; Male; Malondialdehyde; Mice, Inbred C57BL; NF-kappa B; Random Allocation; Reactive Oxygen Species; Signal Transduction | 2014 |
SCM-198 inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-кB pathways.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Cognition Disorders; Cytokines; Gallic Acid; L-Lactate Dehydrogenase; Male; MAP Kinase Kinase 4; Maze Learning; Microglia; Neurons; Neuroprotective Agents; NF-kappa B; Peptide Fragments; Rats; Rats, Sprague-Dawley; Signal Transduction | 2014 |
Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dose-Response Relationship, Drug; Female; Gallic Acid; Inflammation Mediators; Lipopolysaccharides; Mastitis; Mice; Mice, Inbred BALB C; Signal Transduction | 2015 |
Inhibitory effect of leonurine on the formation of advanced glycation end products.
Topics: Animals; Blood Glucose; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Gallic Acid; Glycation End Products, Advanced; Hyperglycemia; Insulin; Leonurus; Mass Spectrometry; Plant Extracts; Pyruvaldehyde; Swine | 2015 |
A study on the PK and BA profiles in the mouse body for leonurine O/O microemulsion with determination by the LC-MS/MS method.
Topics: Administration, Oral; Animals; Arginine; Biological Availability; Chromatography, High Pressure Liquid; Drug Delivery Systems; Emulsions; Gallic Acid; Mice; Solubility; Suspensions; Tandem Mass Spectrometry; Water | 2016 |
Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways.
Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Fluorescent Antibody Technique; Gallic Acid; Humans; Mice; Mice, Inbred BALB C; NF-kappa B; Osteoclasts; Osteoporosis, Postmenopausal; Ovariectomy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2015 |
Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibrosis; Gallic Acid; Kidney; Kidney Diseases; Mice, Inbred C57BL; NF-kappa B; Protective Agents; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta; Urethral Obstruction | 2015 |
Leonurine hydrochloride induces apoptosis of H292 lung cancer cell by a mitochondria-dependent pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Gallic Acid; Humans; Lamiaceae; Lung Neoplasms; Mitochondria; Plant Extracts | 2015 |
GABAA Receptor Binding Assays of Standardized Leonurus cardiaca and Leonurus japonicus Extracts as Well as Their Isolated Constituents.
Topics: Animals; Anti-Anxiety Agents; Gallic Acid; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Leonurus; Male; Molecular Structure; Plant Extracts; Proline; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards | 2015 |
SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice.
Topics: Amyloid beta-Peptides; Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Gallic Acid; Humans; Male; Maze Learning; Membrane Glycoproteins; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Protein-Tyrosine Kinases; Signal Transduction | 2015 |
Characterization of a Monoclonal Antibody against Syringate Derivatives: Application of Immunochemical Detection of Methyl Syringate in Honey.
Topics: Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Food Analysis; Gallic Acid; Honey; Mice | 2016 |
Synthesis and biological evaluation of the codrug of Leonurine and Aspirin as cardioprotective agents.
Topics: Apoptosis; Aspirin; Cardiotonic Agents; Catalase; Cell Line; Gallic Acid; Humans; Inflammation Mediators; L-Lactate Dehydrogenase; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase | 2016 |
Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy.
Topics: Animals; Autophagy; Brain; Cognitive Dysfunction; Disease Models, Animal; Excitatory Postsynaptic Potentials; Gallic Acid; Glutamates; Hippocampus; Neuroprotective Agents; Pyramidal Cells; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spatial Memory | 2016 |
Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Diterpenes; Gallic Acid; Leonurus; Plant Extracts; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors | 2017 |
Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis.
Topics: Adenomyosis; Animals; Cyclooxygenase 2; Endometriosis; Female; Gallic Acid; Hyperalgesia; Mice; Mice, Inbred ICR; Random Allocation; Receptors, Oxytocin; Tamoxifen | 2017 |
Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis.
Topics: Adult; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Female; Fibroblasts; Gallic Acid; Humans; Inflammation Mediators; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Mice; Middle Aged; Mitogen-Activated Protein Kinases; Protein Transport; Signal Transduction; Synovial Membrane; Synoviocytes; Transcription Factor RelA | 2017 |
Soluble epoxide hydrolase inhibitory activity of components from Leonurus japonicus.
Topics: Epoxide Hydrolases; Gallic Acid; Leonurus; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Conformation; Solubility | 2017 |
Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain; Cell Survival; Gallic Acid; L-Lactate Dehydrogenase; Male; Mice; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Stroke | 2017 |
[Determination of stachydrine hydrochloride and leonurine hydrochloride in Yimucao preparations by HPLC-MS].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gallic Acid; Leonurus; Proline; Tandem Mass Spectrometry | 2016 |
Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation.
Topics: Animals; Antidepressive Agents; Calcium-Binding Proteins; Cytokines; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Fluoxetine; Food Preferences; Gallic Acid; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Neurons; Neurotransmitter Agents; Prefrontal Cortex; Stress, Psychological; Swimming | 2017 |
Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; Cell Line; Cholesterol; Gallic Acid; Humans; Leonurus; Lipid Metabolism; Liver X Receptors; Male; Mice; PPAR gamma; Signal Transduction; Up-Regulation | 2017 |
Effects of leonurine on intracerebral haemorrhage by attenuation of perihematomal edema and neuroinflammation
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Body Water; Brain Edema; Cerebral Hemorrhage; Encephalitis; Gallic Acid; Hematoma; Inflammation Mediators; Male; Matrix Metalloproteinase 9; Oxyhemoglobins; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Upregulating mTOR/ERK signaling with leonurine for promoting angiogenesis and tissue regeneration in a full-thickness cutaneous wound model.
Topics: Angiogenesis Inducing Agents; Animals; Cell Movement; Disease Models, Animal; Drugs, Chinese Herbal; Extracellular Signal-Regulated MAP Kinases; Gallic Acid; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Pathologic; Rats; Regeneration; Signal Transduction; Skin; TOR Serine-Threonine Kinases; Wound Healing; Wounds and Injuries | 2018 |
Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arthritis, Gouty; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Gallic Acid; Humans; Inflammation; Macrophages; Male; Mice; Molecular Docking Simulation; Prostaglandin-E Synthases; Protein Structure, Secondary; Rats; Rats, Wistar; RAW 264.7 Cells; Uric Acid | 2018 |
Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway.
Topics: Administration, Oral; Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Cerebrovascular Disorders; Coronary Vessels; Disease Models, Animal; Drug Administration Schedule; Echocardiography; Gallic Acid; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Male; Myocardial Infarction; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis.
Topics: Animals; Anti-Inflammatory Agents; Cattle; Cells, Cultured; Disease Models, Animal; Endometritis; Endometrium; Epithelial Cells; Female; Gallic Acid; Interleukin-1beta; Leonurus; Lipopolysaccharides; Mice; NF-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Neuroprotective effects of leonurine against oxygen-glucose deprivation by targeting Cx36/CaMKII in PC12 cells.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Survival; Connexins; Gallic Acid; Gap Junction delta-2 Protein; Glucose; Mefloquine; Neuroprotective Agents; Oxygen; PC12 Cells; Rats; Signal Transduction | 2018 |
Leonurine hydrochloride promotes osteogenic differentiation and increases osteoblastic bone formation in ovariectomized mice by Wnt/β-catenin pathway.
Topics: Animals; beta Catenin; Bone Density; Cell Differentiation; Cell Line; Core Binding Factor Alpha 1 Subunit; Female; Gallic Acid; Gene Expression Regulation; Mice, Inbred C57BL; Osteoblasts; Osteogenesis; Osteoporosis; Ovariectomy; Wnt Signaling Pathway | 2018 |
Leonurine inhibits IL-1β induced inflammation in murine chondrocytes and ameliorates murine osteoarthritis.
Topics: Animals; Chondrocytes; Disease Models, Animal; Gallic Acid; Gene Expression Regulation; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Osteoarthritis | 2018 |
Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress.
Topics: Animals; Apoptosis; Disease Models, Animal; Doxorubicin; Gallic Acid; Humans; Kidney; Kidney Diseases; Macrophages; Mice; Oxidative Stress; Podocytes; Proteinuria; Reactive Oxygen Species; Wounds and Injuries | 2018 |
Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Extracellular Matrix; Gallic Acid; Humans; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Signal Transduction | 2019 |
Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives.
Topics: Gallic Acid; Humans; Leonurus; Medicine, Chinese Traditional; Molecular Structure; Phytotherapy | 2016 |
The anti-inflammatory and antioxidant effects of leonurine hydrochloride after lipopolysaccharide challenge in broiler chicks.
Topics: Animal Feed; Animals; Chickens; Diet; Dietary Supplements; Gallic Acid; Inflammation; Lipopolysaccharides; Male; Oxidative Stress; Poultry Diseases | 2019 |
Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway.
Topics: Adenylate Kinase; Animals; Choline Deficiency; Dose-Response Relationship, Drug; Gallic Acid; Hep G2 Cells; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Protective Agents; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2019 |
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.
Topics: Animals; Cell Differentiation; Central Nervous System; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gallic Acid; Humans; Inflammation; Jumonji Domain-Containing Histone Demethylases; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Neurogenesis; Oligodendroglia; Remyelination | 2019 |
Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells.
Topics: Animals; Antidepressive Agents; Cell Survival; Gallic Acid; Immediate-Early Proteins; Neuronal Outgrowth; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Receptors, Glucocorticoid; Signal Transduction | 2019 |
Dietary leonurine hydrochloride supplementation attenuates lipopolysaccharide challenge-induced intestinal inflammation and barrier dysfunction by inhibiting the NF-κB/MAPK signaling pathway in broilers.
Topics: Animals; Antioxidants; Chickens; Cytokines; Dietary Supplements; Gallic Acid; Inflammation; Intestinal Mucosa; Lipopolysaccharides; Male; Malondialdehyde; MAP Kinase Signaling System; NF-kappa B; Occludin; Tight Junction Proteins | 2019 |
Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold-stagnation and blood-stasis primary dysmenorrhoea after the administration of Leonurus japonicus houtt electuary.
Topics: Animals; Drugs, Chinese Herbal; Dysmenorrhea; Female; Gallic Acid; Humans; Leonurus; Proline; Rats; Rats, Sprague-Dawley | 2019 |
Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.
Topics: Animals; Cardiotonic Agents; Cell Line; Gallic Acid; Lipopolysaccharides; Male; Mice, Inbred C57BL; Myocarditis; Myocytes, Cardiac; NF-kappa B; Rats; Signal Transduction | 2019 |
SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways.
Topics: Apoptosis; bcl-2-Associated X Protein; Cell Survival; Cells, Cultured; Gallic Acid; Humans; Hydrogen Peroxide; Leonurus; MAP Kinase Signaling System; Models, Biological; Oxidants; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Stromal Cells | 2019 |
Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2-related factor 2 pathway.
Topics: Animals; Brain Ischemia; Gallic Acid; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Neuroprotective Agents; NF-E2-Related Factor 2; Signal Transduction; Stroke | 2019 |
Leonurine Exerts Anti-Catabolic and Anti-Apoptotic Effects via Nuclear Factor kappa B (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways in Chondrocytes.
Topics: ADAM Proteins; Animals; Apoptosis; Cells, Cultured; Chondrocytes; Gallic Acid; Interleukin-1beta; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoarthritis; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
The Effect of Leonurine on Multiterritory Perforator Flap Survival in Rats.
Topics: Animals; Apoptosis; Drug Evaluation, Preclinical; Gallic Acid; Leonurus; Male; Neovascularization, Physiologic; Oxidative Stress; Perforator Flap; Phytotherapy; Plant Extracts; Rats, Sprague-Dawley; Tissue Survival; Vascular Endothelial Growth Factor A | 2020 |
Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway.
Topics: Aging; Animals; Antioxidants; Galactose; Gallic Acid; Gene Expression Regulation; Mice; Molecular Structure; Motor Activity; NF-E2-Related Factor 2; Signal Transduction | 2019 |
Leonurine Hydrochloride Suppresses Inflammatory Responses and Ameliorates Cartilage Degradation in Osteoarthritis via NF-κB Signaling Pathway.
Topics: ADAMTS5 Protein; Animals; Anterior Cruciate Ligament; Anti-Inflammatory Agents; Cartilage Diseases; Cartilage, Articular; Cell Line; Chondrocytes; Gallic Acid; Inflammation; Interleukin-6; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; NF-kappa B; Osteoarthritis; Rats | 2020 |
The Guanidine Pseudoalkaloids 10-Methoxy-Leonurine and Leonurine Act as Competitive Inhibitors of Tyrosinase.
Topics: Alkaloids; Binding, Competitive; Catalytic Domain; Cluster Analysis; Enzyme Inhibitors; Gallic Acid; Guanidine; Inhibitory Concentration 50; Kinetics; Melanins; Molecular Docking Simulation; Molecular Structure; Monophenol Monooxygenase; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2020 |
eNOS-Nitric Oxide System Contributes to a Novel Antiatherogenic Effect of Leonurine via Inflammation Inhibition and Plaque Stabilization.
Topics: Animals; Atherosclerosis; Cell Line; Gallic Acid; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Plaque, Atherosclerotic; Signal Transduction | 2020 |
CYP2A13 Acts as the Main Metabolic CYP450s Enzyme for Activating Leonurine in Human Bronchial Epithelial Cells.
Topics: Aryl Hydrocarbon Hydroxylases; Bronchi; Cell Line; Epithelial Cells; Gallic Acid; Humans; Inactivation, Metabolic | 2020 |
Design and synthesis of novel SCM-198 analogs as cardioprotective agents: Structure-activity relationship studies and biological evaluations.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Gallic Acid; Molecular Structure; Myocardial Infarction; Protective Agents; Rats; Structure-Activity Relationship | 2020 |
Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gallic Acid; Humans; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Inhibitory Effects of Standardized
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cell Survival; Cytokines; Gallic Acid; Leonurus; Liver; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Myoblasts; NF-kappa B; Phosphatidylinositol 3-Kinases; Plant Extracts; Rats; Tumor Necrosis Factor-alpha | 2020 |
Leonurine improves in vitro porcine embryo development competence by reducing reactive oxygen species production and protecting mitochondrial function.
Topics: Animals; Blastocyst; Embryo Culture Techniques; Embryonic Development; Gallic Acid; Mitochondria; Reactive Oxygen Species; Swine | 2020 |
Leonurine protects against dexamethasone-induced cytotoxicity in pancreatic β-cells via PI3K/Akt signaling pathway.
Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cytoprotection; Dexamethasone; Gallic Acid; Glucocorticoids; Insulin-Secreting Cells; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2020 |
Leonurine Regulates Treg/Th17 Balance to Attenuate Rheumatoid Arthritis Through Inhibition of TAZ Expression.
Topics: Acyltransferases; Arthritis, Rheumatoid; Biomarkers; CD4-Positive T-Lymphocytes; Gallic Acid; Gene Expression Profiling; Gene Expression Regulation; Humans; Immunohistochemistry; Immunophenotyping; T-Lymphocytes, Regulatory; Th17 Cells; Transcription Factors | 2020 |
Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Mediate the Disposition of Leonurine-10-O-β-glucuronide.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2; Gallic Acid; Glucuronides; Hypolipidemic Agents; Male; Mice; Mice, Knockout; Microsomes, Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Tissue Distribution | 2020 |
Leonurine Attenuates Myocardial Fibrosis Through Upregulation of miR-29a-3p in Mice Post-myocardial Infarction.
Topics: Angiotensin II; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Gallic Acid; Male; Mice, Inbred C57BL; MicroRNAs; Myocardial Infarction; Myocardium; Transforming Growth Factor beta; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2021 |
SCM-198 ameliorates endometrial inflammation via suppressing the LPS-JNK-cJUN/cFOS-TLR4-NF-κB pathway.
Topics: Adult; Animals; Anti-Inflammatory Agents; Cytokines; Endometritis; Endometrium; Epithelial Cells; Female; Gallic Acid; Humans; Lipopolysaccharides; MAP Kinase Signaling System; Mice, Inbred C57BL; NF-kappa B; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Stromal Cells; Toll-Like Receptor 4 | 2021 |
Alkaloid leonurine exerts anti-inflammatory effects via modulating MST1 expression in trophoblast cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Female; Gallic Acid; Humans; Mice; NF-kappa B; Pregnancy; Trophoblasts | 2021 |
Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt-eNOS Signaling Pathway in H
Topics: Cell Movement; Cell Survival; Gallic Acid; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Malondialdehyde; Medicine, Chinese Traditional; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2021 |
Leonurine protects against influenza A virus infection-induced pneumonia in mice.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Gallic Acid; Gene Expression Regulation; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung Injury; Mice; Mice, Inbred BALB C; NF-kappa B; Orthomyxoviridae Infections; Pneumonia; Signal Transduction; Specific Pathogen-Free Organisms; Swine; Toll-Like Receptor 4 | 2021 |
Anti-leukaemia effects of leonurine in vitro and in vivo.
Topics: Animals; Gallic Acid; HL-60 Cells; Humans; Leukemia; Mice; Mice, Nude; Phosphatidylinositol 3-Kinases | 2021 |
Leonurine hydrochloride-a new drug for the treatment of menopausal syndrome: Synthesis, estrogen-like effects and pharmacokinetics.
Topics: Animals; Biological Availability; Blotting, Western; Body Weight; Estrus; Female; Gallic Acid; Humans; Hydroxybenzoates; Male; Menopause; Mice; Mice, Inbred ICR; Ovary; Random Allocation; Rats; Sincalide; Uterus; Vagina | 2022 |
Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Gallic Acid; Injections, Intraperitoneal; Leonurus; Male; Molecular Structure; NF-E2-Related Factor 2; NF-kappa B; Pentobarbital; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 4 | 2022 |
Leonurine attenuates cisplatin nephrotoxicity by suppressing the NLRP3 inflammasome, mitochondrial dysfunction, and endoplasmic reticulum stress.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cisplatin; Endoplasmic Reticulum Stress; Gallic Acid; Inflammasomes; Mice; Mice, Inbred C57BL; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
[Effect and mechanism of leonurine on pressure overload-induced cardiac hypertrophy in rats].
Topics: Angiotensin II; Animals; Cardiomegaly; Gallic Acid; Hypertrophy, Left Ventricular; Myocardium; Rats | 2022 |
Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ferroptosis; Gallic Acid; Iron Overload; Male; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Up-Regulation | 2022 |
Leonurine exerts a protective effect in dextran sodium sulfate-induced experimental inflammatory bowel disease mice model.
Topics: Animals; Anti-Inflammatory Agents; Dextran Sulfate; Disease Models, Animal; Gallic Acid; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; NF-kappa B; Sulfates | 2022 |
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
Topics: Animals; Carrageenan; Carrier Proteins; Gallic Acid; Mice; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pleurisy; Thioredoxins | 2022 |
Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway.
Topics: Acute Kidney Injury; Animals; Cisplatin; Ferroptosis; Gallic Acid; Iron; Mice; NF-E2-Related Factor 2 | 2022 |
SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4
Topics: Animals; Endometriosis; Estrogen Receptor alpha; Estrogens; Female; Gallic Acid; Humans; Mice; T-Lymphocytes, Regulatory | 2022 |
Inhibition of poly (ADP-ribose) polymerase 1 in neuron cells might enhance the therapeutic effect of leonurine under cholesterol stimulation.
Topics: Adenosine Diphosphate; Cholesterol; Gallic Acid; Neurons; Phosphatidylinositol 3-Kinases; Ribose | 2022 |
Leonurine Protects Bone Mesenchymal Stem Cells from Oxidative Stress by Activating Mitophagy through PI3K/Akt/mTOR Pathway.
Topics: Animals; Gallic Acid; Humans; Hydrogen Peroxide; Mesenchymal Stem Cells; Mitophagy; Osteoporosis; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; TOR Serine-Threonine Kinases | 2022 |
SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell
Topics: Animals; Aromatase; Autophagy; Endometriosis; Endometrium; Estrogen Receptor alpha; Estrogens; Female; Gallic Acid; Humans; Mice; Receptors, Progesterone; Stromal Cells; Tumor Necrosis Factor-alpha | 2022 |
Leonurine Reduces Oxidative Stress and Provides Neuroprotection against Ischemic Injury via Modulating Oxidative and NO/NOS Pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Gallic Acid; Glucose; Ischemia; Neuroprotection; Neuroprotective Agents; Nitric Oxide Synthase; Oxidative Stress; Oxygen; Rats; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2022 |