galantamine and tacrine

galantamine has been researched along with tacrine in 127 studies

Research

Studies (127)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (2.36)	18.7374
1990's	10 (7.87)	18.2507
2000's	59 (46.46)	29.6817
2010's	49 (38.58)	24.3611
2020's	6 (4.72)	2.80

Authors

Authors	Studies
Bigg, DC; Briley, M; Calmel, F; Carilla, E; Vidaluc, JL	1
Bigg, D; Briley, M; Calmel, F; Carilla, E; Chopin, P; Stenger, A; Vidaluc, JL	1
Guillou, C; Mary, A; Renko, DZ; Thal, C	1
Gras, E; Guillou, C; Mary, A; Renko, DZ; Thal, C	1
Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X	1
Espinoza-Fonseca, M; Montoya Cano, L; Trujillo-Ferrara, J	1
Guillou, C; Herlem, D; Martin, MT; Thal, C	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Alley, GM; Brossi, A; Deschamps, JR; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, D; Yu, QS; Zhan, M	1
Gütschow, M; Pietsch, M	1
Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS	1
Baier, E; Ellmerer, EP; Langer, T; Rollinger, JM; Schuster, D; Stuppner, H	1
Choudhary, MI; Ghayur, MN; Gilani, AH; Khalid, A; Khan, MR; Mesaik, MA; Sultana, N	1
Chang, Y; Di, YT; Ding, M; Dong, JH; Hao, XJ; He, HP; Lu, Y; Mu, SZ; Sun, QY; Wang, YH; Yang, FM; Zhang, ZK; Zheng, QT	1
Andrisano, V; Banzi, R; Bartolini, M; Bergamini, C; Bolognesi, ML; Cattaneo, A; Cavalli, A; Fato, R; Hrelia, P; Lenaz, G; Melchiorre, C; Minarini, A; Recanatini, M; Rosini, M; Tarozzi, A; Tumiatti, V	1
Barlier, M; Chiaroni, A; Gresh, N; Guenard, D; Guillou, C; Herlem, D; Sauvaître, T	1
Lombardo, F; Obach, RS; Waters, NJ	1
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A	1
Gu, LQ; Huang, SL; Huang, ZS; Ma, L; Ning, FX; Qiao, W; Tang, H; Wei, YB; Zhang, C	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Arnold, N; Brandt, W; Geissler, T; Kehlen, A; Porzel, A; Schlenzig, D; Wessjohann, L	1
Budesínský, M; Cegan, A; Cejka, J; Havlícek, V; Kopecký, J; Lukesová, A; Zelík, P	1
Gaube, F; Heilmann, J; Lehmann, J; Rook, Y; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B	1
de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Al-Rashid, ZF; Hsung, RP	2
Chen, X; Decker, M; Tikhonova, IG	1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M	1
Boido, V; Carotti, A; Catto, M; Giangreco, I; Nicolotti, O; Novelli, F; Pisani, L; Sparatore, A; Sparatore, F; Tasso, B; Tonelli, M	1
Chen, X; Decker, M; Fleck, C; Heilmann, J; Kling, B; Kraus, B; Lupp, A; Zenger, K	1
Huang, L; Li, XS; Mao, F; Meng, FC; Qin, F; Shan, WJ	1
Bazureau, JP; Burgy, G; Carreaux, F; Cochet, C; Delhommel, F; Durieu, E; Elkins, JM; Filippakopoulos, P; Knapp, S; Lo, DC; Meijer, L; Oberholzer, AE; Pearl, LH; Schmid, RS; Soundararajan, M; Tahtouh, T	1
Chen, Q; Lin, HY; Peng, DY; Sun, Q; Yang, GF; Yang, WC; Yu, NX; Zhu, XL	1
Carotti, A; Catto, M; Cellamare, S; Leonetti, F; Nicolotti, O; Pesce, P; Pisani, L; Stefanachi, A	1
Cardoso, CL; Cass, QB; Corrêa, AG; Vanzolini, KL; Vieira, LC	1
Hu, XJ; Kong, LY; Li, RS; Wang, XB	1
Kong, LY; Li, JY; Wang, XB; Xie, SS; Yang, L	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Jiang, N; Kong, LY; Li, SY; Sun, HB; Wang, KD; Wang, XB; Xie, SS; Yao, HQ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Boonyarat, C; Reubroycharoen, P; Thiratmatrakul, S; Tohda, M; Vajragupta, O; Waiwut, P; Yenjai, C	1
Castro-Gamboa, I; Cuendet, M; da Silva Bolzani, V; Ebrahimi, SN; Hamburger, M; Marcourt, L; Queiroz, EF; Queiroz, MM; Wolfender, JL; Zeraik, ML	1
Chen, Y; Fang, L; Fang, X; Fleck, C; Gou, S; Huang, Z; Lenhardt, I; Lupp, A; Sun, Y; Zhang, Y	1
Bansal, G; Bansal, Y; Sandhu, S; Silakari, O	1
Peng, DY; Sun, Q; Yang, GF; Yang, SG; Yang, WC; Zhu, XL	1
Kong, LY; Lan, JS; Li, SY; Pan, LF; Wang, XB; Xie, SS	1
Amooru, GD; Ampasala, DR; Darla, MM; Devineni, SR; Eadlapalli, S; Kotapati, KV; Palaka, BK; Penumala, M; Shaik, JB; Vadde, R	1
Hoda, N; Jameel, E; Jayaram, B; Kumar, J; Maqbool, M; Meena, P; Mobashir, M; Shandilya, A; Singh, A; Tiwari, M	1
Beazely, MA; Mohamed, T; Osman, W; Rao, PP; Sit, VM; Vasefi, MS	1
Cañadas, S; García-Font, N; Iodice, C; Marco-Contelles, J; Oset-Gasque, MJ; Pejin, B; Tommonaro, G; Vitale, RM	1
Brazzolotto, X; Chan, S; De la Mora, E; Deora, GS; Dighe, SN; Nachon, F; Parat, MO; Ross, BP	1
Ibrar, A; Khan, I; Saeed, F; Shehzadi, SA	1
Brazzolotto, X; Colletier, JP; Coquelle, N; Gobec, S; Jukič, M; Knez, D; Kos, J; Mravljak, J; Nachon, F; Pišlar, A; Sova, M; Žakelj, S	1
Akbarzadeh, T; Amini, M; Asadi, M; Bukhari, SNA; Ghobadian, R; Khaleghzadeh-Ahangar, H; Mahdavi, M; Moradi, A; Nadri, H; Sharifzadeh, M	1
Kumar, A; Mishra, P; Panda, G	1
Ji, J; Peng, Y; Rakesh, KP; Wang, S; Xu, M; Zhu, L	1
Bartolini, M; Bolognesi, ML; Fernández-Bolaños, JG; Franconetti, A; Hicke, J; Lagunes, I; López, Ó; Maya, I; Monti, B; Naldi, M; Padrón, JM; Petralla, S; Poeta, E; Roldán-Peña, JM; Romero-Real, V	1
Cui, Z; Gao, J; Geng, H; Li, D; Li, H; Zhou, B; Zhou, L	1
Curtis, MA; Lin, SX; Sperry, J	1
Amoroso, R; Carradori, S; De Filippis, B; Fantacuzzi, M	1
Andricopulo, AD; Cenci, AR; de Oliveira, AS; Ferreira, LLG; Machado, V; Nunes, RJ; Sandjo, LP; Sens, L; Teixeira, KF; Tizziani, T; Yunes, RA	1
Ardab'eva, TV; Tonkopiĭ, VD	1
Prozorovskiĭ, VB; Suslova, IM; Tonkopiĭ, VD	1
Padinker, EB; Tonkopiĭ, VD	1
Briley, M; Chopin, P	1
Barz, H; Bickel, U; Cervos-Navarro, J; Fischer, JP; Gusztony, G; Kaden, B; Kewitz, H; Thomsen, T	1
Bahro, M; Berger, M; Gann, H; Hohagen, F; Lis, S; Riemann, D; Stadmüller, G	1
Johansson, M; Nordberg, A	1
Camacho, F; Smith, CP; Vargas, HM; Winslow, JT	1
Mielke, R	1
MacGowan, SH; Scott, M; Wilcock, GK	1
Danysz, W; Moebius, HJ; Quack, G; Wenk, GL	1
Bucks, RS; Byrne, LM; Hughes, AO; Wilcock, GK; Wilson, PM	1
Stahl, SM	1
Giacobini, E	1
Kashiwagi, Y; Kudo, T; Nakamura, Y; Nishikawa, T; Shinosaki, K; Takeda, M; Tanaka, T	1
Hake, AM	1
Winblad, B	1
Allain, H; Bentue-Ferrer, D; Lecavorzin, P; Polard, E; Reymann, JM; Tribut, O	1
Robert, P	1
Ott, BR	1
Kamei, H; Nabeshima, T; Noda, Y	1
Albuquerque, EX; Christner, C; Fehrenbacher, A; Höffle, A; Jostock, R; Lübbert, H; Ludwig, J; Maelicke, A; Pereira, EF; Radina, M; Samochocki, M; Ullmer, C; Zerlin, M	1
Butler, R; Prabhakaran, P; Warner, J	1
Fuchsberger, T; Hampel, H; Möller, HJ	1
Haen, E; Ibach, B	1
Caricati-Neto, A; D'angelo, LC; Garcia, AG; Hyppolito Jurkiewicz, N; Jurkiewicz, A; Reuter, H	1
Arya, P; Butler, R; Warner, J	2
Miyanaga, K	1
Bermudez, I; Groot-Kormelink, PJ; Smulders, CJ; van Kleef, RG; Vijverberg, HP; Zwart, R	1
Barnes, WG; Boyd, DL; Herrick-Davis, K; Hough, LB; Taraschenko, OD; Yokoyama, Y	1
Aisen, PS	1
Chen, HZ; Dong, CZ; Ezoulin, MJ; Heymans, F; Lelièvre, L; Li, J; Liu, Z; Massicot, F; Ombetta, JE	1
Butler, R; Warner, J; Wuntakal, B	1
Cummings, JL; Ringman, JM	1
Beck, C; Blank, K; Colenda, CC; Doraiswamy, MP; Kalunian, DA; Lyketsos, CG; Yaffe, K	1
Carelli, V; Costa, N; De Vita, D; Liberatore, F; Marra, R; Rispoli, V; Rotiroti, D; Scipione, L	1
Takatori, Y	1
Akaike, A; Fujii, T; Katsuki, H; Kume, T; Niidome, T; Okabe, S; Sugimoto, H; Sugimoto, M; Takada-Takatori, Y	1
Ballard, CG; Chalmers, KA; Love, S; McKeith, IG; O'Brien, JT; Perry, EK; Todd, C; Wilcock, G	1
McCain, KR; Sawyer, TS; Spiller, HA	1
Bajda, M; Malawska, B; Musiał, A	1
Adelman, A; Campos-Outcalt, D; Cross, JT; Forciea, MA; Hopkins, R; Mehr, D; Owens, DK; Qaseem, A; Santaguida, P; Schellhase, K; Shekelle, P; Snow, V	1
Booker, L; Cowan, D; Ismaila, A; Levine, M; Oremus, M; Patterson, C; Raina, P; Santaguida, P	1
Graham, L	1
Hornick, A; Prast, H; Rollinger, JM; Schwaiger, S; Stuppner, H; Vo, NP	1
Graham, K; Josif, S	1
Akaike, A; Fujii, T; Izumi, Y; Kume, T; Niidome, T; Ohgi, Y; Sugimoto, H; Takada-Takatori, Y	1
Ehret, A; Feuerstein, TJ; Förster, S; Jackisch, R; Kammerer, M; Rothmaier, AK; Zentner, J	1
Auber, A; Chiamulera, C; Giarola, A	1
Aw, CC; Browne, ER; Chen, CP; Goh, CW; Lee, JH	1
Okochi, M; Takeda, M; Tanaka, T	1
Atri, A	1
Fujiwara, H; Inada, C; Matsumoto, K; Miyata, T; Thi Le, X; Tsuneyama, K	1
Ahnaou, A; Drinkenburg, WH; Huysmans, H; Jacobs, T	1
Draczkowski, P; Halczuk, P; Jozwiak, K; Matosiuk, D; Strzemski, M; Tomaszuk, A	1
Bezerra da Silva, C; Dalarmi, L; Dallarmi Miguel, M; de Fátima Gaspari Dias, J; de Oliveira, M; Elifio-Esposito, S; Fialho do Nascimento, K; Gomes Miguel, O; Moura Burci, L; Pott, A; Warumby Zanin, SM	1
Bartolini, M; Fabini, E; Tramarin, A	1
Ahmed, M; Aleya, L; Ashraf, GM; Barreto, GE; Begum, MM; Kabir, MT; Mathew, B; Rahman, MS; Thangapandiyan, S; Uddin, MS	1
Han, MS; Yoo, S	1
Aksoz, BE; Aksoz, E	1
Chmielewska, K; Dzierzbicka, K; Inkielewicz-Stepniak, I; Kowalski, S; Przybyłowska, M	1

Reviews

30 review(s) available for galantamine and tacrine

Article	Year
Coumarin hybrids as novel therapeutic agents. Bioorganic & medicinal chemistry, 2014, Aug-01, Volume: 22, Issue:15 Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Cell Survival; Coumarins; Drug Design; Drug Resistance, Multiple, Bacterial; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding	2014
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery. Bioorganic & medicinal chemistry, 2018, 07-30, Volume: 26, Issue:13 Topics: Aldehyde Reductase; Alkaline Phosphatase; Cholinesterases; Coumarins; Drug Design; Enzymes; Glucosidases; Humans; Molecular Docking Simulation; Monoamine Oxidase	2018
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). Bioorganic & medicinal chemistry, 2019, 03-15, Volume: 27, Issue:6 Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Ligands; Neuroprotective Agents	2019
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Triazoles	2019
Pyridine alkaloids with activity in the central nervous system. Bioorganic & medicinal chemistry, 2020, 12-15, Volume: 28, Issue:24 Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic	2020
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. European journal of medicinal chemistry, 2022, Apr-05, Volume: 233 Topics: Humans; Neurodegenerative Diseases; Polyphenols; Resveratrol; Stilbenes; Structure-Activity Relationship	2022
Pharmacokinetic studies of cholinesterase inhibitors. Acta neurologica Scandinavica. Supplementum, 1993, Volume: 149 Topics: Adult; Aged; Alzheimer Disease; Female; Galantamine; Humans; Male; Middle Aged; Physostigmine; Tacrine	1993
Cholinesterase inhibitors stabilize Alzheimer's disease. Annals of the New York Academy of Sciences, 2000, Volume: 920 Topics: Alzheimer Disease; Brain; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon	2000
Use of cholinesterase inhibitors for treatment of Alzheimer disease. Cleveland Clinic journal of medicine, 2001, Volume: 68, Issue:7 Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2001
[Perspectives for drug treatment in Alzheimer's disease]. Annales de medecine interne, 2001, Volume: 152, Issue:8 Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2001
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine. Current medical research and opinion, 2002, Volume: 18, Issue:3 Topics: Acetylcholine; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Disease Progression; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome	2002
Medical treatment of Alzheimer's disease: past, present, and future. Medicine and health, Rhode Island, 2002, Volume: 85, Issue:7 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forecasting; Galantamine; Humans; Indans; Male; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome	2002
[Anti-dementia drugs for Alzheimer disease in present and future]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 120, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; tau Proteins	2002
Dementia. Clinical evidence, 2003, Issue:9 Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E	2003
[Current therapy of patients with dementia]. MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2 Topics: Activities of Daily Living; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Controlled Clinical Trials as Topic; Dementia; Dementia, Vascular; Donepezil; Dopamine Agents; Female; Galantamine; Ginkgo biloba; Humans; Indans; Male; Memantine; Meta-Analysis as Topic; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Placebos; Plant Preparations; Prospective Studies; Rivastigmine; Tacrine; Time Factors	2003
Acetylcholinesterase inhibition in Alzheimer's Disease. Current pharmaceutical design, 2004, Volume: 10, Issue:3 Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2004
Dementia. Clinical evidence, 2004, Issue:11 Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamine; Ginkgo biloba; Haloperidol; Humans; Indans; Memantine; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Risperidone; Rivastigmine; Selegiline; Tacrine; Vitamin E	2004
Dementia. Clinical evidence, 2004, Issue:12 Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine	2004
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management. Journal of the American Academy of Nurse Practitioners, 2005, Volume: Suppl Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome	2005
Dementia. Clinical evidence, 2005, Issue:14 Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Selegiline; Tacrine	2005
Current and emerging pharmacological treatment options for dementia. Behavioural neurology, 2006, Volume: 17, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2006
[Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2006, Volume: 126, Issue:8 Topics: Alzheimer Disease; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Humans; Indans; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine	2006
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment. Current medicinal chemistry, 2007, Volume: 14, Issue:25 Topics: Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Indole Alkaloids; Isoquinolines; Phenylcarbamates; Physostigmine; Piperidines; Propidium; Rivastigmine; Steroids; Tacrine	2007
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5 Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine	2008
Diagnosis and treatment of dementia with Lewy bodies. JAAPA : official journal of the American Academy of Physician Assistants, 2008, Volume: 21, Issue:5 Topics: Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Nootropic Agents; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Tacrine	2008
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:3 Topics: Acetylcholinesterase; Animals; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Indans; Neurons; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine; Up-Regulation	2009
New drugs for Alzheimer's disease in Japan. Psychiatry and clinical neurosciences, 2011, Volume: 65, Issue:5 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Japan; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2011
Effective pharmacological management of Alzheimer's disease. The American journal of managed care, 2011, Volume: 17 Suppl 13 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Dementia; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome	2011
Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning. Current pharmaceutical design, 2019, Volume: 25, Issue:33 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Repositioning; Galantamine; Humans; Rivastigmine; Tacrine	2019
Vital Role of Monoamine Oxidases and Cholinesterases in Central Nervous System Drug Research: A Sharp Dissection of the Pathophysiology. Combinatorial chemistry & high throughput screening, 2020, Volume: 23, Issue:9 Topics: Central Nervous System Agents; Central Nervous System Diseases; Cholinesterases; Combined Modality Therapy; Donepezil; Drug Design; Enzyme Inhibitors; Galantamine; Humans; Monoamine Oxidase; Rivastigmine; Structure-Activity Relationship; Tacrine	2020

Trials

2 trial(s) available for galantamine and tacrine

Article	Year
Cholinergic neurotransmission, REM sleep and depression. Journal of psychosomatic research, 1994, Volume: 38 Suppl 1 Topics: Adolescent; Adult; Aged; Alzheimer Disease; Brain Stem; Cholinergic Agonists; Cholinergic Fibers; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Galantamine; Humans; Male; Mental Disorders; Middle Aged; Parasympathomimetics; Physostigmine; Polysomnography; Reaction Time; Receptors, Muscarinic; Sleep Stages; Sleep Wake Disorders; Sleep, REM; Succinimides; Synaptic Transmission; Tacrine	1994
Effect of gender and apolipoprotein E genotype on response to anticholinesterase therapy in Alzheimer's disease. International journal of geriatric psychiatry, 1998, Volume: 13, Issue:9 Topics: Alzheimer Disease; Apolipoproteins E; Cholinesterase Inhibitors; Double-Blind Method; Female; Galantamine; Genotype; Humans; Male; Sex Characteristics; Tacrine; Time Factors	1998

Article

Year

Cholinergic neurotransmission, REM sleep and depression.

Journal of psychosomatic research, 1994, Volume: 38 Suppl 1

Topics: Adolescent; Adult; Aged; Alzheimer Disease; Brain Stem; Cholinergic Agonists; Cholinergic Fibers; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Galantamine; Humans; Male; Mental Disorders; Middle Aged; Parasympathomimetics; Physostigmine; Polysomnography; Reaction Time; Receptors, Muscarinic; Sleep Stages; Sleep Wake Disorders; Sleep, REM; Succinimides; Synaptic Transmission; Tacrine

1994

Effect of gender and apolipoprotein E genotype on response to anticholinesterase therapy in Alzheimer's disease.

International journal of geriatric psychiatry, 1998, Volume: 13, Issue:9

Topics: Alzheimer Disease; Apolipoproteins E; Cholinesterase Inhibitors; Double-Blind Method; Female; Galantamine; Genotype; Humans; Male; Sex Characteristics; Tacrine; Time Factors

1998

Other Studies

95 other study(ies) available for galantamine and tacrine

Article	Year
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation. Journal of medicinal chemistry, 1995, Jul-21, Volume: 38, Issue:15 Topics: Animals; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Molecular Conformation; Rats; Structure-Activity Relationship; Thiourea	1995
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity. Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5 Topics: Acetylcholinesterase; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Dementia; Dose-Response Relationship, Drug; Hydrogen Bonding; Mice; Molecular Conformation; Molecular Structure; Piperidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea	1994
Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:10 Topics: Acetylcholinesterase; Benzazepines; Binding Sites; Catalytic Domain; Cholinesterase Inhibitors; Drug Design; Galantamine; Phthalimides; Structure-Activity Relationship	1998
Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts. Bioorganic & medicinal chemistry letters, 2000, Apr-03, Volume: 10, Issue:7 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dimerization; Drug Design; Galantamine; Structure-Activity Relationship	2000
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17 Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship	2002
Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives. Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10 Topics: 4-Aminobenzoic Acid; Animals; Cholinesterase Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Structure-Activity Relationship	2003
Synthesis and structure-activity relationships of open D-Ring galanthamine analogues. Bioorganic & medicinal chemistry letters, 2003, Jul-21, Volume: 13, Issue:14 Topics: Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Electric Organ; Electrophorus; Galantamine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Substrate Specificity	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4 Topics: Acetylcholinesterase; Amyloid beta-Protein Precursor; Benzofurans; Butyrylcholinesterase; Carbamates; Cell Line; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Neurons; Oxepins; Structure-Activity Relationship	2005
Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition. Journal of medicinal chemistry, 2005, Dec-29, Volume: 48, Issue:26 Topics: Acetylcholinesterase; Animals; Cattle; Cholinesterase Inhibitors; Electrophorus; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Kinetics; Oxazines; Sterol Esterase; Structure-Activity Relationship	2005
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7 Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo	2006
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana. Journal of natural products, 2006, Volume: 69, Issue:9 Topics: Alkaloids; Animals; Austria; Cholinesterase Inhibitors; Crystallography, X-Ray; Electrophorus; Galantamine; Hydrogen Bonding; Ligands; Magnolia; Plant Bark; Plant Leaves; Plants, Medicinal	2006
New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. Journal of enzyme inhibition and medicinal chemistry, 2006, Volume: 21, Issue:6 Topics: Alkaloids; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Jejunum; Kinetics; Quinolines; Rabbits	2006
Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase. Journal of natural products, 2007, Volume: 70, Issue:9 Topics: Acetylcholinesterase; Antiviral Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Hosta; Molecular Conformation; Molecular Structure; Plants, Medicinal; Tobacco Mosaic Virus	2007
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease. Journal of medicinal chemistry, 2007, Oct-04, Volume: 50, Issue:20 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Humans; Ligands; Models, Molecular; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Polyamines; Protein Binding; Quinones; Reactive Oxygen Species; Structure-Activity Relationship; Substrate Specificity	2007
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series. Journal of medicinal chemistry, 2007, Nov-01, Volume: 50, Issue:22 Topics: Acetylcholinesterase; Animals; Benzoxazines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Crystallography, X-Ray; Electrophorus; Heterocyclic Compounds, 4 or More Rings; Humans; Models, Molecular; Molecular Structure; Species Specificity; Structure-Activity Relationship; Torpedo; Triterpenes	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine	2008
Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase. European journal of medicinal chemistry, 2009, Volume: 44, Issue:6 Topics: Acetylcholinesterase; Alkaloids; Animals; Aporphines; Butyrylcholinesterase; Computer Simulation; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Models, Chemical; Models, Molecular; Molecular Structure; Reproducibility of Results; Stereoisomerism; Torpedo	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Acetylcholinesterase; Agaricales; Animals; Cattle; Cholinesterase Inhibitors; Erythrocytes; Fruiting Bodies, Fungal; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Stereoisomerism; Structure-Activity Relationship	2010
Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp. str. Lukesová 27/97. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:3 Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclopentanes; Humans; Inhibitory Concentration 50; Molecular Structure; Nostoc	2010
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Alzheimer Disease; Butyrylcholinesterase; Carbolines; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Humans; Inhibitory Concentration 50; Memantine; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate	2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives. Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase. Bioorganic & medicinal chemistry letters, 2011, May-01, Volume: 21, Issue:9 Topics: Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Inhibitory Concentration 50; Models, Biological; Models, Molecular; Molecular Structure; Pyrans	2011
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors. Bioorganic & medicinal chemistry, 2011, Feb-01, Volume: 19, Issue:3 Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemical Phenomena; Cholinesterase Inhibitors; Cholinesterases; Colorimetry; Drug Design; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Protein Binding; Quinazolines; Structure-Activity Relationship	2011
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2011
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Crystallography, X-Ray; Dose-Response Relationship, Drug; Erythrocytes; Models, Molecular; Molecular Structure; Quinolizidines; Stereoisomerism; Structure-Activity Relationship	2011
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo. Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11 Topics: Acetylcholinesterase; Allosteric Regulation; Animals; Butyrylcholinesterase; Cell Count; Cell Line; Cell Survival; Cholinesterase Inhibitors; Cognition; Eels; Female; Glutamic Acid; Hepatic Stellate Cells; Horses; Lipid Peroxidation; Liver; Maze Learning; Mice; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Silybin; Silymarin; Tacrine	2012
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents. Bioorganic & medicinal chemistry letters, 2012, Jul-01, Volume: 22, Issue:13 Topics: Acetylcholinesterase; Alzheimer Disease; Chelating Agents; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Kinetics; Metals; Pyridines; Structure-Activity Relationship	2012
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. Journal of medicinal chemistry, 2012, Nov-08, Volume: 55, Issue:21 Topics: Alkaloids; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Cell Line; Chromatography, Affinity; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Dioxoles; Dyrk Kinases; Glutamic Acid; Humans; Imidazoles; In Vitro Techniques; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Porifera; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship	2012
Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Benzamides; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Molecular Docking Simulation; Protein Structure, Tertiary; Quinolinium Compounds	2012
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase. Bioorganic & medicinal chemistry, 2013, Jan-01, Volume: 21, Issue:1 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Coumarins; Horses; Humans	2013
Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening. Journal of medicinal chemistry, 2013, Mar-14, Volume: 56, Issue:5 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Chromatography, Liquid; Coumarins; Enzymes, Immobilized; Galantamine; High-Throughput Screening Assays; Inhibitory Concentration 50; Kinetics; Ligands; Tacrine; Tandem Mass Spectrometry	2013
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2013, May-01, Volume: 23, Issue:9 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Catalytic Domain; Cholinesterase Inhibitors; Drug Design; Flavonoids; Humans; Kinetics; Molecular Docking Simulation; Peptide Fragments; Structure-Activity Relationship	2013
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. European journal of medicinal chemistry, 2013, Volume: 64 Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tacrine	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2013, Volume: 69 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flavonoids; Free Radical Scavengers; Humans; Mice; Neuroblastoma; Organometallic Compounds; Oxidation-Reduction; Peptide Fragments; Picrates; Structure-Activity Relationship; Tacrine	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2014, Mar-21, Volume: 75 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Butyrylcholinesterase; Carbazoles; Cell Line; Cholinesterase Inhibitors; Electrophorus; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Oxidative Stress; Tacrine	2014
Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents. Journal of natural products, 2014, Mar-28, Volume: 77, Issue:3 Topics: Acetylcholinesterase; Biological Products; Brazil; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Indoles; Inhibitory Concentration 50; Malpighiaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenanthrenes; Plant Bark; Plant Extracts	2014
Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents. European journal of medicinal chemistry, 2014, Apr-09, Volume: 76 Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Drug Design; Female; Galantamine; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Nitric Oxide; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization	2014
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase. Bioorganic & medicinal chemistry, 2014, Sep-01, Volume: 22, Issue:17 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Tacrine	2014
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Carbolines; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Drug Design; Electrophorus; Horses; Humans; Molecular Docking Simulation; Protein Aggregation, Pathological; Tacrine	2014
A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase. Bioorganic & medicinal chemistry letters, 2015, Nov-01, Volume: 25, Issue:21 Topics: Acetylcholinesterase; Animals; Binding Sites; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Molecular Docking Simulation; Molecular Structure; Pyrans; Stereoisomerism; Structure-Activity Relationship	2015
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents. European journal of medicinal chemistry, 2016, Jan-01, Volume: 107 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Binding Sites; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Computer Simulation; Coumarins; Drug Evaluation, Preclinical; Galantamine; Humans; Hydrogen Peroxide; Male; Mice, Inbred BALB C; Models, Molecular; Neuroprotective Agents; Neurotoxicity Syndromes	2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies. European journal of medicinal chemistry, 2016, Aug-25, Volume: 119 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Humans; Kinetics; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Protein Conformation; Pyrimidines	2016
Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease. Chemical biology & drug design, 2016, Volume: 88, Issue:5 Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amyloid beta-Peptides; Binding Sites; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship	2016
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease. European journal of medicinal chemistry, 2016, Oct-21, Volume: 122 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Hep G2 Cells; Humans; Liver; Molecular Docking Simulation; Neuroprotective Agents; Protein Conformation; Sesquiterpenes	2016
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening. Journal of medicinal chemistry, 2016, 08-25, Volume: 59, Issue:16 Topics: Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship	2016
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. European journal of medicinal chemistry, 2018, Aug-05, Volume: 156 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Butyrylcholinesterase; Caco-2 Cells; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Models, Molecular; Neuroprotective Agents; Piperidines	2018
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors. Bioorganic & medicinal chemistry, 2018, 09-15, Volume: 26, Issue:17 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Carbazoles; Cholinesterase Inhibitors; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Piperidines; Rats	2018
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors. European journal of medicinal chemistry, 2019, Nov-01, Volume: 181 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antineoplastic Agents; Butyrylcholinesterase; Cell Proliferation; Cholinesterase Inhibitors; Dimerization; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Electrophorus; Horses; Humans; Ligands; Models, Molecular; Molecular Structure; Neuroprotective Agents; Phenols; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured	2019
Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase. European journal of medicinal chemistry, 2020, Aug-15, Volume: 200 Topics: Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Discovery; Humans; Inhibitory Concentration 50; Isoquinolines; Molecular Docking Simulation; Structure-Activity Relationship	2020
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies. RSC medicinal chemistry, 2022, Dec-14, Volume: 13, Issue:12 Topics:	2022
[Effect of reversible inhibitors on the reaction capacity of functional portions of the active center of acetylcholinesterase]. Biulleten' eksperimental'noi biologii i meditsiny, 1978, Volume: 86, Issue:10 Topics: Acetylcholinesterase; Ambenonium Chloride; Armin; Binding Sites; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Galantamine; Humans; Organothiophosphorus Compounds; Phosphorylation; Tacrine	1978
[Interaction of reversible inhibitors with the catalytic centers and allosteric sites of cholinesterases]. Biulleten' eksperimental'noi biologii i meditsiny, 1976, Volume: 82, Issue:8 Topics: Allosteric Site; Ambenonium Chloride; Animals; Brain; Catalysis; Cats; Chickens; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Erythrocytes; Galantamine; Humans; Hydrolysis; Kinetics; Mice; Tacrine	1976
[Effect of reversible inhibitors on the thermal denaturation of cholinesterases]. Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 79, Issue:4 Topics: Acridines; Animals; Brain; Cholinesterases; Galantamine; Hot Temperature; Mice; Molecular Conformation; Rats; Tacrine	1975
Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology, 1992, Volume: 106, Issue:1 Topics: Amnesia; Animals; Avoidance Learning; Cognition; Dihydroergotoxine; Dose-Response Relationship, Drug; Galantamine; Ginkgo biloba; Male; Nicergoline; Piracetam; Plant Extracts; Rats; Rats, Inbred Strains; Scopolamine; Secologanin Tryptamine Alkaloids; Tacrine; Yohimbine	1992
Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1991, Volume: 29, Issue:8 Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Erythrocytes; Female; Galantamine; Hippocampus; Humans; Male; Mice; Middle Aged; Physostigmine; Tacrine	1991
Alpha 2-adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat. Psychopharmacology, 1996, Volume: 124, Issue:4 Topics: Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Benzazepines; Cholinesterase Inhibitors; Drug Synergism; Galantamine; Idazoxan; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine; Yohimbine	1996
[Neuroprotective therapy of Alzheimer's disease?]. Deutsche medizinische Wochenschrift (1946), 1996, Nov-29, Volume: 121, Issue:48 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Galantamine; Humans; Neuroprotective Agents; Physostigmine; Piracetam; Tacrine	1996
No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use. Life sciences, 2000, Feb-11, Volume: 66, Issue:12 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Memantine; Piperidines; Rats; Rats, Inbred F344; Tacrine	2000
The sensitivity to change over time of the Bristol Activities of Daily Living Scale in Alzheimer's disease. International journal of geriatric psychiatry, 2000, Volume: 15, Issue:7 Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Clinical Trials as Topic; Female; Galantamine; Humans; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Psychiatric Status Rating Scales; Psychometrics; Reproducibility of Results; Sensitivity and Specificity; Tacrine	2000
The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different. The Journal of clinical psychiatry, 2000, Volume: 61, Issue:10 Topics: Aged; Alzheimer Disease; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Receptors, Nicotinic; Rivastigmine; Tacrine	2000
[Treatment of the elderly dementia patients]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2000, Volume: 37, Issue:11 Topics: Aged; Alzheimer Disease; Benzazepines; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Piperidines; Tacrine; Trichlorfon	2000
Maintaining functional and behavioral abilities in Alzheimer disease. Alzheimer disease and associated disorders, 2001, Volume: 15 Suppl 1 Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Treatment Outcome	2001
Galantamine: new preparation. The fourth cholinesterase inhibitor for Alzheimer's disease. Prescrire international, 2001, Volume: 10, Issue:56 Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; France; Galantamine; Indans; Tacrine; Treatment Outcome	2001
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3 Topics: Allosteric Regulation; Animals; Carbamates; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Mice; Neurons; Phenylcarbamates; Piperidines; Receptors, Muscarinic; Receptors, Nicotinic; Recombinant Fusion Proteins; Rivastigmine; Tacrine; Trichlorfon	2003
Anticholinesterases in Alzheimer's disease: a modest effect on moderately severe disease. Prescrire international, 2003, Volume: 12, Issue:68 Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; France; Galantamine; Humans; Indans; Piperidines; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Tacrine; Treatment Outcome	2003
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens. European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3 Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Electric Stimulation; Galantamine; In Vitro Techniques; Indans; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Receptors, Purinergic; Rivastigmine; Stimulation, Chemical; Synaptic Transmission; Tacrine; Vas Deferens	2004
[Treatment of dementia]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2005, Volume: 42, Issue:1 Topics: Cerebrovascular Circulation; Cholinesterase Inhibitors; Dementia; Exercise; Galantamine; Humans; Nutritional Support; Receptors, Neurotransmitter; Tacrine	2005
Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. European journal of pharmacology, 2005, Feb-21, Volume: 509, Issue:2-3 Topics: Acetylcholine; Alkaloids; Animals; Atropine; Azocines; Binding, Competitive; Cholinergic Agents; Cholinesterase Inhibitors; Dichlorvos; Dose-Response Relationship, Drug; Female; Galantamine; Humans; Membrane Potentials; Models, Biological; Nicotine; Oocytes; Phenylcarbamates; Physostigmine; Plasmids; Quinolizines; Receptors, Nicotinic; Rivastigmine; Scopolamine; Tacrine; Xenopus laevis	2005
Actions of tacrine and galanthamine on histamine-N-methyltransferase. Methods and findings in experimental and clinical pharmacology, 2005, Volume: 27, Issue:3 Topics: Animals; Brain; Cloning, Molecular; DNA, Complementary; Enzyme Inhibitors; Galantamine; Histamine N-Methyltransferase; Humans; In Vitro Techniques; Kidney; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tacrine	2005
Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. Toxicology in vitro : an international journal published in association with BIBRA, 2006, Volume: 20, Issue:6 Topics: Cell Survival; Cholinesterase Inhibitors; Furans; Galantamine; Humans; Lipid Peroxidation; Liver; Membrane Potentials; Mitochondria; Oxidative Stress; Platelet Activating Factor; Tacrine	2006
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006, Volume: 14, Issue:7 Topics: Aged; Alkaloids; Alzheimer Disease; Brain; Caregivers; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Diagnostic and Statistical Manual of Mental Disorders; Galantamine; Geriatric Psychiatry; Health Services for the Aged; Humans; Phenylcarbamates; Professional-Family Relations; Rivastigmine; Sesquiterpenes; Tacrine; United States	2006
Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats. Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:3 Topics: Animals; Behavior, Animal; Choline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Enzyme Inhibitors; Galantamine; Male; Rats; Rats, Wistar; Scopolamine; Tacrine	2006
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity. European journal of pharmacology, 2006, Nov-07, Volume: 549, Issue:1-3 Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Cysteine; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Fetus; Galantamine; Glutamic Acid; Ionomycin; Ionophores; Mecamylamine; Neuroprotective Agents; Nicotinic Antagonists; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitrosothiols; Tacrine	2006
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies. Neurology, 2007, May-15, Volume: 68, Issue:20 Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Autopsy; Cerebral Cortex; Cholinesterase Inhibitors; Clinical Trials as Topic; Cohort Studies; Donepezil; Drug Evaluation; Female; Galantamine; Humans; Indans; Lewy Body Disease; Male; Middle Aged; Neuroprotective Agents; Phenylcarbamates; Piperidines; Prospective Studies; Rivastigmine; Tacrine; tau Proteins; Tauopathies	2007
Evaluation of centrally acting cholinesterase inhibitor exposures in adults. The Annals of pharmacotherapy, 2007, Volume: 41, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Gastrointestinal Diseases; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Poison Control Centers; Retrospective Studies; Rivastigmine; Tacrine	2007
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations. Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5 Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine	2008
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5 Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine	2008
AAFP and ACP release guideline on dementia treatment. American family physician, 2008, Apr-15, Volume: 77, Issue:8 Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Guidelines as Topic; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2008
Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: brain ACh increasing and memory improving properties. Biochemical pharmacology, 2008, Jul-15, Volume: 76, Issue:2 Topics: Acetylcholinesterase; Animals; Asteraceae; Behavior, Animal; Brain; Cholinesterase Inhibitors; Female; Galantamine; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine	2008
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex. Journal of Alzheimer's disease : JAD, 2009, Volume: 16, Issue:3 Topics: Acetylcholine; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Galantamine; Humans; In Vitro Techniques; Indans; Middle Aged; Neocortex; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine; Young Adult	2009
Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats. Behavioural pharmacology, 2011, Volume: 22, Issue:1 Topics: Animals; Cholinesterase Inhibitors; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Galantamine; Generalization, Stimulus; Male; Nicotine; Nicotinic Agonists; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine	2011
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Aging; Animals; Biological Availability; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Galantamine; Half-Life; Hypothermia; Indans; Male; Metabolic Clearance Rate; Piperidines; Random Allocation; Rats; Rats, Inbred Strains; Receptor, Muscarinic M2; Salivation; Tacrine; Tears; Tremor	2011
Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures. European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3 Topics: Acetylcholine; Animals; Blotting, Western; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Galantamine; Hippocampus; Indans; Mice; Mice, Inbred ICR; N-Methylaspartate; Organ Culture Techniques; Piperidines; Receptor, Muscarinic M1; Tacrine	2013
Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential. Neuropharmacology, 2014, Volume: 86 Topics: Animals; Cerebral Cortex; Cognition; Donepezil; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Galantamine; Gamma Rhythm; Indans; Male; Memantine; Motor Activity; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Phenylcarbamates; Piperidines; Principal Component Analysis; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Signal Processing, Computer-Assisted; Tacrine; Theta Rhythm	2014
Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry. Biochimica et biophysica acta, 2016, Volume: 1860, Issue:5 Topics: Acetylcholine; Acetylcholinesterase; Ambenonium Chloride; Animals; Calorimetry; Cholinesterase Inhibitors; Donepezil; Edrophonium; Electrophorus; Fish Proteins; Galantamine; Indans; Kinetics; Piperidines; Tacrine; Thermodynamics	2016
Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina. Molecules (Basel, Switzerland), 2016, Jan-11, Volume: 21, Issue:1 Topics: Animals; Cholinesterase Inhibitors; Convulsants; Donepezil; Galantamine; Indans; Locomotion; Models, Biological; Piperidines; Planarians; Rivastigmine; Seizures; Survival Rate; Tacrine	2016
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening. Journal of pharmaceutical and biomedical analysis, 2018, Jun-05, Volume: 155 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; Edrophonium; Enzymes, Immobilized; Galantamine; Humans; Indans; Kinetics; Ligands; Piperidines; Recombinant Fusion Proteins; Serum Albumin; Surface Plasmon Resonance; Tacrine	2018
A fluorescent probe for butyrylcholinesterase activity in human serum based on a fluorophore with specific binding affinity for human serum albumin. Chemical communications (Cambridge, England), 2019, Dec-18, Volume: 55, Issue:97 Topics: Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Fluorescence; Fluorescent Dyes; Galantamine; Humans; Molecular Structure; Serum Albumin, Human; Spectrometry, Fluorescence; Tacrine	2019
Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors. Current neuropharmacology, 2021, Volume: 19, Issue:8 Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; Rivastigmine; Tacrine	2021