galangin and pinosylvin

galangin has been researched along with pinosylvin* in 2 studies

Other Studies

2 other study(ies) available for galangin and pinosylvin

ArticleYear
Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae).
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Apr-15, Volume: 18, Issue:6

    The leaves of the Japanese Alnus sieboldiana have been extracted with n-hexane and then with methanol. A bioactivity-guided approach based on MTT assay for growth inhibition and quantitative real-time PCR for TNF-α inhibitory activity was taken to identify the active compounds in EtOAc soluble fraction of the methanol extract. From this active fraction, seven compounds have been isolated and four compounds (pinosylvin, galangin, quercetin and methyl gallate) have been examined for their dose-response effect on the viability of A549 cells and on TNF-α inhibitory activity. Based on MTT assay, all of the four examined compounds inhibit growth of human lung cancer cells. Among four tested compounds only galangin (3,5,7-trihydroxyflavone) significantly inhibited TNF-α gene expression in A549 cells (IC₅₀ = 94 μM). Taken together, this finding suggests that galangin may be useful in cancer prevention.

    Topics: Alnus; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dose-Response Relationship, Drug; Flavonoids; Gallic Acid; Humans; Lung Neoplasms; Phytotherapy; Plant Extracts; Plant Leaves; Quercetin; Stilbenes; Tumor Necrosis Factor-alpha

2011
Taxonomic significance of flavonoid variation in temperate species of Nothofagus.
    Phytochemistry, 2003, Volume: 62, Issue:7

    Forty-two flavonoids and a stilbene (pinosylvin) were identified in the leaf exudates of 11 temperate species of Nothofagus from South America, Australia and New Zealand. The flavonoid profiles demonstrate significant taxonomic value at the subgeneric level. Most species of subgenus Fuscospora are characterized by the presence of pinosylvin, galangin and galangin methyl ethers. Kaempferol-type flavonols are abundant in subgenus Lophozonia while these flavonols are largely absent from species of subgenus Fuscospora. The flavonoid patterns are largely in agreement with a recent subgeneric classification of Nothofagus.

    Topics: Cluster Analysis; Flavonoids; Magnoliopsida; Phylogeny; Plant Leaves; Species Specificity; Stilbenes

2003