Page last updated: 2024-08-21

galactitol and tolrestat

galactitol has been researched along with tolrestat in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's5 (62.50)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bauman, JG; Dietrich, A; Gorham, BJ; Harrison, MC; Jones, LR; Kelly, JM; Malamas, M; Millen, J; Sredy, J; Wrobel, J1
Dvornik, D; Gonzalez, R; Greselin, E; Simard-Duquesne, N1
Abraham, N; Bellini, F; Dvornik, D; Fung, S; Humber, L; Sestanj, K; Simard-Duquesne, N; Treasurywala, A1
Epstein, M; Forster, HG; Hohman, TC; ter Wee, PM1
Burgan, J; Faller, A; Obrosova, I; Ostrow, E; Williamson, JR1
Berry, GT; Frangos, M; Palmieri, M; Reynolds, R; Segal, S; Wehrli, S; Williamson, JR1
Banditelli, S; Boldrini, E; Cappiello, M; Cecconi, I; Dal Monte, M; Del Corso, A; Marini, I; Mura, U; Vilardo, PG1
Kador, PF; Zhang, P; Zhang, Z1

Other Studies

8 other study(ies) available for galactitol and tolrestat

ArticleYear
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Administration, Oral; Aldehyde Reductase; Animals; Cattle; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Diaphragm; Galactitol; Galactose; Glycine; Lens, Crystalline; Male; Molecular Structure; Naphthalenes; Prodrugs; Rats; Rats, Inbred Strains; Sciatic Nerve

1991
Prevention of cataract development in severely galactosemic rats by the aldose reductase inhibitor, tolrestat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 178, Issue:4

    Topics: Animals; Cataract; Dose-Response Relationship, Drug; Galactitol; Galactose; Galactosemias; Humans; Lens, Crystalline; Male; Naphthalenes; Rats

1985
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:3

    Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Galactitol; Isoquinolines; Lens, Crystalline; Naphthalenes; Rats; Sorbitol; Sugar Alcohol Dehydrogenases

1984
Impairment of afferent arteriolar myogenic responsiveness in the galactose-fed rat is prevented by tolrestat.
    Diabetologia, 1996, Volume: 39, Issue:8

    Topics: Aldehyde Reductase; Angiotensin II; Animals; Arterioles; Blood Pressure; Cohort Studies; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet; Disease Models, Animal; Enzyme Inhibitors; Galactitol; Galactose; Image Processing, Computer-Assisted; In Vitro Techniques; Kidney; Male; Muscle, Smooth, Vascular; Naphthalenes; Perfusion; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents

1996
Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor.
    Current eye research, 1997, Volume: 16, Issue:1

    Topics: Aldehyde Reductase; Animals; Energy Metabolism; Enzyme Inhibitors; Galactitol; Galactose; Galactosemias; Gas Chromatography-Mass Spectrometry; Glycolysis; Inositol; Lens, Crystalline; Male; NADP; Naphthalenes; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley

1997
Elevation of erythrocyte redox potential linked to galactonate biosynthesis: elimination by Tolrestat.
    Metabolism: clinical and experimental, 1998, Volume: 47, Issue:11

    Topics: Adult; Enzyme Inhibitors; Erythrocytes; Female; Galactitol; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Middle Aged; Naphthalenes; Oxidation-Reduction; Sugar Acids; UDPglucose-Hexose-1-Phosphate Uridylyltransferase

1998
A new approach against sugar cataract through aldose reductase inhibitors.
    Experimental eye research, 1999, Volume: 69, Issue:5

    Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Enzyme Inhibitors; Galactitol; Galactose; Lens, Crystalline; Naphthalenes; Rats; Rats, Sprague-Dawley

1999
Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2014, Volume: 30, Issue:1

    Topics: Aldehyde Reductase; Animals; Capillaries; Cell Line; Endothelial Cells; Fluorenes; Galactitol; Galactose; Glucose; Hydantoins; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Naphthalenes; Pericytes; Rats; Rats, Transgenic; Retinal Vessels; Sorbitol

2014