gadoxetic-acid-disodium and methacetin

Topics: Acetamides; Breath Tests; Carbon Isotopes; Contrast Media; Female; Gadolinium DTPA; Humans; Image Enhancement; Liver; Liver Diseases; Liver Function Tests; Magnetic Resonance Imaging; Male; Middle Aged; Reproducibility of Results; Retrospective Studies

To determine whether liver function as determined by intravenous administration of. Sixty-six patients underwent a. Stratified by three different categories of. Liver function as determined using real-time. • Gd-EOB-DTPA-enhanced T1 relaxometry quantifies liver function • Gd-EOB-DTPA-enhanced MR relaxometry may provide parameters for assessing liver function before surgery • Gd-EOB-DTPA-enhanced MR relaxometry may be useful for monitoring liver disease progression • Gd-EOB-DTPA-enhanced MR relaxometry has the potential to become a novel liver function index.

Topics: Acetamides; Aged; Breath Tests; Carbon Isotopes; Contrast Media; Disease Progression; Female; Gadolinium DTPA; Humans; Liver; Liver Diseases; Liver Function Tests; Magnetic Resonance Imaging; Male; Middle Aged; Observer Variation; Reproducibility of Results; Retrospective Studies

Gadoxetic acid (Gd-EOB-DTPA) is a paramagnetic MRI contrast agent with raising popularity and has been used for evaluation of imaging-based liver function in recent years. In order to verify whether liver function as determined by real-time breath analysis using the intravenous administration of

Topics: Acetamides; Adult; Aged; Aged, 80 and over; Breath Holding; Breath Tests; Carbon Isotopes; Female; Gadolinium DTPA; Humans; Image Enhancement; Liver; Liver Function Tests; Magnetic Resonance Imaging; Male; Middle Aged; Reproducibility of Results; Retrospective Studies

Contrast enhanced magnetic resonance imaging (MRI) is able to assess liver function by characteristic changes of signal intensity (SI).The aim was to evaluate dynamic contrast-enhanced SI-indices of the abdominal aorta, portal vein and liver.. 72 patients underwent Gd-EOB-DTPA-enhanced MRI and a 13C-methacetin-based liver breath test (13C-MBT) for evaluation of liver function. Region-of-interest measurements in the liver, abdominal aorta and portal vein during native, arterial (AP), late arterial (LAP), portal venous (PVP) and hepatobiliary phase (HBP) were applied to analyze SI-indices in T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat-suppression and relative enhancement (RE) analysis was performed.. The liver (p < 0.001), the portal vein (p < 0.001) and abdominal aorta (p = 0.002) showed significant decrease of REs with decreasing liver function. An increasing trend between logarithmic values of 13C-MBT and REs of hepatic parenchyma (HBP; r = 0.662, p < 0.001), portal vein (PVP; r = 0.532, p < 0.001) and abdominal aorta (PVP; r = 0.421, p < 0.001) was observed.. RE measurements of the hepatic parenchyma proofed to be a trustable evaluation method for liver function evaluation. In accordance with liver function, changes of REs in the portal vein and abdominal aorta occur.

Topics: Acetamides; Breath Tests; Female; Gadolinium DTPA; Humans; Liver Function Tests; Male; Middle Aged; Retrospective Studies