gacyclidine has been researched along with piperidines in 36 studies
| Studies (gacyclidine) | Trials (gacyclidine) | Recent Studies (post-2010) (gacyclidine) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 36 | 1 | 2 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (25.00) | 18.2507 |
| 2000's | 22 (61.11) | 29.6817 |
| 2010's | 5 (13.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drian, MJ; Kamenka, JM; Pirat, JL; Privat, A | 1 |
| Calvet, MC; Kamenka, JM; Levallois, C; Petite, D | 1 |
| Baldet, P; Levallois, C; Privat, A; Valence, C | 1 |
| Baubichon, D; Brochier, G; Burckhart, MF; Carpentier, P; Kamenka, JM; Lallement, G; Mestries, JC; Peoc'h, M; Privat, A; Sentenac-Roumanou, H | 1 |
| Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Masqueliez, C; Mestries, JC; Peoc'h, M | 1 |
| Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Peoc'h, M | 1 |
| Baubichon, D; Carpentier, P; Clarençon, D; Galonnier, M; Lallement, G; Peoc'h, M | 1 |
| Baccard, N; D'Arbigny, P; Gourdier, B; Hoizey, G; Lamiable, D; Millart, H; Vistelle, R | 1 |
| Lallement, G | 1 |
| d'Arbigny, P; Gaviria, M; Haton, H; Kamenka, JM; Ohanna, F; Privat, A | 1 |
| Hirbec, H; Privat, A; Vignon, J | 1 |
| Darrell, RS; Fulop, ZL; Levinsohn, SA; Smith, JS; Stein, DG | 1 |
| Hirbec, H; Kamenka, J; Privat, A; Teilhac, J; Vignon, J | 1 |
| d'Arbigny, P; Dukic, S; Hoizey, G; Lamiable, D; Millart, H; Vistelle, R | 1 |
| D'Arbigny, P; Dukic, S; Hoizey, G; Kaltenbach, ML; Lallemand, A; Lamiable, D; Millart, H; Vistelle, R | 2 |
| Barbanel, G; Kamenka, JM; Laplanche, L | 1 |
| d'Arbigny, P; Gaviria, M; Haton, H; Kamenka, J; Ohanna, F; Privat, A | 1 |
| Arnaud, S; D'Arbigny, P; Feldblum, S; Rabin, O; Simon, M | 1 |
| Hirbec, H; Kamenka, JM; Privat, A; Vignon, J | 2 |
| Gaviria, M; Hirbec, H; Vignon, J | 1 |
| Maynard, KI; Mitha, AP | 1 |
| D'Arbigny, P; Dukic, S; Hoizey, G; Kaltenbach, ML; Lamiable, D; Millart, H; Vistelle, R | 1 |
| Hirbec, H; Kamenka, JM; Mausset, AL; Privat, A; Vignon, J | 1 |
| Privat, A | 1 |
| Barbanel, G; Cambonie, G; Hirbec, H; Kamenka, JM; Michaud, M | 1 |
| D'Arbigny, P; Delcour, J; Kempf, C; Lepeintre, JF; Loubert, G; Mathé, JF; Tadié, M; Vigué, B | 1 |
| Bhagat, YA; Hamilton, MG; Kendall, EJ; Mikler, J; Obenaus, A | 1 |
| Becerril Ortega, J; Buisson, A; Crouzin, N; Desmadryl, G; Hirbec, H; Privat, A; Teigell, M; Vandame, D | 1 |
| Lenarz, T; Stöver, T; Warnecke, A; Wenzel, GI | 1 |
| Asencio, G; Gaviria, M; Haton, H; Kouyoumdjian, P; Lonjon, N; Perrin, FE; Prieto, M; Privat, A | 1 |
| Bauchet, L; Gaviria, M; Haton, H; Kouyoumdjian, P; Lonjon, N; Perrin, FE; Prieto, M; Privat, A | 1 |
| Noraberg, J; Ring, A; Tanso, R | 1 |
| Hirbec, H; Nesic, O; Perez-Polo, R; Prieto-Cappellini, M; Privat, A; Teigell, M; Ulmann, L; Vandame, D; Vignon, J | 1 |
| Albertson, TE; Chenoweth, JA; Clarke, SO; Ford, JB; Gerona, RR; Owen, KP; Rose, JS; Sutter, ME | 1 |
4 review(s) available for gacyclidine and piperidines
| Article | Year |
|---|---|
Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist attack by soman.
Topics: Animals; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Haplorhini; Humans; N-Methylaspartate; Organophosphorus Compounds; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Soman; Time Factors | 1999 |
Gacyclidine: a new neuroprotective agent acting at the N-methyl-D-aspartate receptor.
Topics: Animals; Binding Sites; Cells, Cultured; Cyclohexanes; Cyclohexenes; Humans; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2001 |
Gacyclidine (Beaufour-Ipsen).
Topics: Animals; Clinical Trials as Topic; Contraindications; Cyclohexanes; Cyclohexenes; Humans; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2001 |
[Repair of the mammalian central nervous system: the "spinal cord" model].
Topics: Animals; Axons; Cyclohexanes; Cyclohexenes; Fetal Tissue Transplantation; Male; Mammals; Mice; Mice, Knockout; Models, Animal; Nerve Regeneration; Neuronal Plasticity; Neurons; Neuroprotective Agents; Piperidines; Rats; Spinal Cord Injuries | 2003 |
1 trial(s) available for gacyclidine and piperidines
| Article | Year |
|---|---|
Neuroprotective effect of gacyclidine. A multicenter double-blind pilot trial in patients with acute traumatic brain injury.
Topics: Adolescent; Adult; Aged; Blood Pressure; Brain Injuries; Cyclohexanes; Cyclohexenes; Double-Blind Method; Electrocardiography; Endpoint Determination; Female; Glasgow Coma Scale; Humans; Intracranial Pressure; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Physical Examination; Pilot Projects; Piperidines; Prospective Studies; Tomography, X-Ray Computed; Treatment Outcome | 2004 |
31 other study(ies) available for gacyclidine and piperidines
| Article | Year |
|---|---|
Non-competitive antagonists of N-methyl-D-aspartate prevent spontaneous neuronal death in primary cultures of embryonic rat cortex.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Embryo, Mammalian; Female; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Pregnancy; Rats; Rats, Inbred Strains | 1991 |
Neuroprotective effect of N-methyl-D-aspartate non-competitive antagonists (arylcyclohexylamine derivatives) on human cultured spinal cord cells.
Topics: Cells, Cultured; Cyclohexanes; Cyclohexenes; Cyclohexylamines; gamma-Aminobutyric Acid; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; N-Methylaspartate; Neurites; Neuroglia; Neurons; Piperidines; Spinal Cord; Stereoisomerism | 1994 |
Morphological and morphometric analysis of serotonin-containing neurons in primary dissociated cultures of human rhombencephalon: a study of development.
Topics: Cell Differentiation; Cell Size; Cells, Cultured; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Fetus; Humans; Illicit Drugs; Neurons; Neuroprotective Agents; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin | 1997 |
GK 11: promising additional neuroprotective therapy for organophosphate poisoning.
Topics: Animals; Cerebral Cortex; Cyclohexanes; Cyclohexenes; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Macaca; Male; Neuroprotective Agents; Organophosphorus Compounds; Piperidines | 1997 |
Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11.
Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cyclohexanes; Cyclohexenes; Diazepam; Drug Combinations; Excitatory Amino Acid Antagonists; Injections, Intravenous; Macaca fascicularis; Male; Muscarinic Antagonists; Neuroprotective Agents; Piperidines; Pralidoxime Compounds; Seizures; Soman; Staining and Labeling; Time Factors | 1998 |
Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support.
Topics: Animals; Anticonvulsants; Antidotes; Atropine; Brain; Cerebellum; Cerebral Cortex; Chemical Warfare Agents; Cholinesterase Reactivators; Cyclohexanes; Cyclohexenes; Diazepam; Drug Therapy, Combination; Electrocardiography; Excitatory Amino Acid Antagonists; Haplorhini; Macaca fascicularis; Male; Piperidines; Poisoning; Pralidoxime Compounds; Seizures; Soman; Time Factors | 1999 |
Modified gas chromatographic-mass spectrometric assay for the determination of gacyclidine enantiomers in human plasma.
Topics: Calibration; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Gas Chromatography-Mass Spectrometry; Humans; Piperidines; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Sensitivity and Specificity | 1999 |
[Interest in an glutamate antagonistic compound for the treatment of organophosphate poisoning].
Topics: Atropine; Cholinesterase Reactivators; Cyclohexanes; Cyclohexenes; Electroencephalography; Excitatory Amino Acid Antagonists; Humans; Organophosphate Poisoning; Piperidines; Poisoning; Pyridostigmine Bromide; Self Administration | 2000 |
Neuroprotective effects of gacyclidine after experimental photochemical spinal cord lesion in adult rats: dose-window and time-window effects.
Topics: Animals; Cyclohexanes; Cyclohexenes; Disease Progression; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Light Coagulation; Male; Motor Activity; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Injuries; Spinal Cord Ischemia | 2000 |
Binding properties of [3H]gacyclidine in the rat central nervous system.
Topics: Animals; Autoradiography; Cerebellum; Cyclohexanes; Cyclohexenes; In Vitro Techniques; Male; Membranes; Neuroprotective Agents; Organ Specificity; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Spinal Cord; Telencephalon; Tritium | 2000 |
Effects of the novel NMDA receptor antagonist gacyclidine on recovery from medial frontal cortex contusion injury in rats.
Topics: Animals; Basal Nucleus of Meynert; Brain Injuries; Cell Count; Cerebral Cortex; Cerebral Ventricles; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Frontal Lobe; gamma-Aminobutyric Acid; Male; Maze Learning; Microglia; Motor Activity; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Swimming | 2000 |
Binding properties of [3H]gacyclidine (cis(pip/me)-1-[1-(2-thienyl)-2-methylcyclohexyl]piperidine) enantiomers in the rat central nervous system.
Topics: Animals; Binding Sites; Binding, Competitive; Central Nervous System; Cerebellum; Cyclohexanes; Cyclohexenes; In Vitro Techniques; Kinetics; Male; Neuroprotective Agents; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Wistar; Spinal Cord; Stereoisomerism; Subcellular Fractions; Tritium | 2000 |
Sensitive gas chromatographic-mass spectrometric method for the determination of gacyclidine in rat plasma and spinal cord dialyzates.
Topics: Animals; Cyclohexanes; Cyclohexenes; Gas Chromatography-Mass Spectrometry; Male; Microdialysis; N-Methylaspartate; Piperidines; Rats; Rats, Wistar; Sensitivity and Specificity | 1999 |
Distribution of gacyclidine enantiomers in spinal cord extracellular fluid.
Topics: Animals; Blood Proteins; Catheterization; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Extracellular Space; Injections, Intravenous; Male; Microdialysis; Piperidines; Protein Binding; Rats; Rats, Wistar; Spinal Cord; Stereoisomerism | 2000 |
The novel non-competitive N-methyl-D-aspartate antagonist gacyclidine blocks the glutamate-induced release of hydroxyl radicals in the striatum under conditions in which dizocilpine does not. A microdialysis study in rats.
Topics: Animals; Binding, Competitive; Corpus Striatum; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Hydroxyl Radical; Male; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Oxidative Stress; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats.
Topics: Animals; Contusions; Cyclohexanes; Cyclohexenes; Electrophysiology; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Weight Gain | 2000 |
Distribution of gacyclidine enantiomers after experimental spinal cord injury in rats: possible involvement of an active transport system.
Topics: Animals; Biological Transport, Active; Calibration; Cyclohexanes; Cyclohexenes; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Neuroprotective Agents; Piperidines; Protein Binding; Rats; Rats, Wistar; Spinal Cord Injuries; Stereoisomerism; Tissue Distribution | 2001 |
Efficacy of a new neuroprotective agent, gacyclidine, in a model of rat spinal cord injury.
Topics: Animals; Astrocytes; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Female; Gliosis; Guanidines; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Stereoisomerism | 2000 |
Interaction of gacyclidine enantiomers with 'non-NMDA' binding sites in the rat central nervous system.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Cerebellum; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Tritium | 2001 |
Characterization of 'non-N-methyl-D-Aspartate' binding sites for gacyclidine enantiomers in the rat cerebellar and telencephalic structures.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cerebellum; Cyclohexanes; Cyclohexenes; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Neurologic Mutants; Neurotransmitter Agents; Organ Specificity; Piperidines; Purkinje Cells; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Telencephalon | 2001 |
Pharmacokinetics of gacyclidine enantiomers in plasma and spinal cord after single enantiomer administration in rats.
Topics: Animals; Blood Proteins; Calibration; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Extracellular Space; Half-Life; Injections, Intravenous; Male; Microdialysis; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stereoisomerism | 2001 |
Re-evaluation of phencyclidine low-affinity or "non-NMDA" binding sites.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Brain Injuries; Cerebellum; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neurons; Neuroprotective Agents; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Subcellular Fractions; Synapses; Synaptic Transmission; Tritium | 2002 |
Prenatal infection obliterates glutamate-related protection against free hydroxyl radicals in neonatal rat brain.
Topics: 2,3-Diketogulonic Acid; Aging; Animals; Animals, Newborn; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Cyclohexanes; Cyclohexenes; Female; Fetal Diseases; Functional Laterality; Glutamic Acid; Hydroxyl Radical; Lipopolysaccharides; Male; Methoxyhydroxyphenylglycol; Neuroprotective Agents; Oxidative Stress; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Subcellular Fractions; Time Factors | 2004 |
Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Cyclohexanes; Cyclohexenes; Diazepam; Diffusion Magnetic Resonance Imaging; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Seizures; Soman; Status Epilepticus | 2005 |
Comparison of the pharmacological properties of GK11 and MK801, two NMDA receptor antagonists: towards an explanation for the lack of intrinsic neurotoxicity of GK11.
Topics: Animals; Cells, Cultured; Cyclohexenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Mice; Neuroprotective Agents; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 2007 |
Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series.
Topics: Administration, Topical; Adolescent; Adult; Audiometry, Pure-Tone; Cochlea; Cyclohexenes; Female; Hearing Loss, Sensorineural; Humans; Male; Middle Aged; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Round Window, Ear; Tinnitus; Young Adult | 2010 |
A remotely controlled model of spinal cord compression injury in mice: toward real-time analysis.
Topics: Animals; Behavior, Animal; Cyclohexenes; Disease Models, Animal; Female; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Motor Activity; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Spinal Cord Compression; Time Factors | 2009 |
Early functional outcomes and histological analysis after spinal cord compression injury in rats.
Topics: Animals; Autonomic Nervous System; Catheterization; Cyclohexenes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Piperidines; Rats; Rats, Wistar; Reflex; Sensory Receptor Cells; Spinal Cord; Spinal Cord Compression; Spinal Cord Injuries; Urination | 2010 |
The use of organotypic hippocampal slice cultures to evaluate protection by non-competitive NMDA receptor antagonists against excitotoxicity.
Topics: Animals; Clinical Trials as Topic; Cyclohexenes; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neuroprotective Agents; Piperidines; Propidium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Development of NMDAR antagonists with reduced neurotoxic side effects: a study on GK11.
Topics: Animals; Astrocytes; Cyclohexenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Gyrus Cinguli; Inflammation; Injections, Intraperitoneal; Memantine; Microglia; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2013 |
Altered mental status and end organ damage associated with the use of gacyclidine: a case series.
Topics: Academic Medical Centers; Adult; Combined Modality Therapy; Cyclohexenes; Designer Drugs; Drug Users; Emergency Service, Hospital; Fatal Outcome; Female; Humans; Illicit Drugs; Male; Middle Aged; Multiple Organ Failure; Neurotoxicity Syndromes; Piperidines; Psychomotor Agitation; Psychotropic Drugs; Rhabdomyolysis; Toxicokinetics; Treatment Outcome; Treatment Refusal | 2015 |