gaboxadol and oxazoles

gaboxadol has been researched along with oxazoles in 92 studies

Research

Studies (92)

Timeframe	Studies, this research(%)	All Research%
pre-1990	90 (97.83)	18.7374
1990's	2 (2.17)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Karobath, M; Lippitsch, M	1
Curtis, DR; Johnston, GA; Lodge, D	1
Jodogne, C; Tirelli, E	1
Belhage, B; Hansen, GH; Meier, E; Schousboe, A	4
Agmo, A; Paredes, R; Soria, P	1
Andersen, JV; Dalgaard, L; Hansen, SH	1
Liske, S; Morris, ME	1
Fujimoto, M; Guidotti, A; Hanbauer, I; Kataoka, Y	1
Cosi, C; Wood, PL	1
Spealman, RD; Wettstein, JG	1
Hansen, SH; Krogsgaard-Larsen, P; Nielsen, EO; Schousboe, A	1
Bruno, G; Chase, TN; Cox, C; Fedio, P; Foster, N; Gillespie, M; Hare, TA; Mohr, E; Tamminga, C	1
Bagri, A; Di Scala, G; Sandner, G	1
Costa, LG; Enna, SJ; Pelley, K; Setler, P; Vaught, JL	1
Gähwiler, BH; Graff, P; Maurer, R; Nordmann, R	1
Depaulis, A; Vergnes, M	2
Hösli, E; Hösli, L; Krogsgaard-Larsen, P	1
Chweh, AY; Swinyard, EA; Ulloque, RA	1
Belhage, B; Meier, E; Schousboe, A	1
Braestrup, C; Krogsgaard-Larsen, P; Nielsen, M	1
Shavrin, AS; Zharkovskaia, TA; Zharkovskiĭ, AM	1
Apud, JA; Masotto, C; Racagni, G	1
Chweh, AY; Swinyard, EA; Wolf, HH	1
Enna, SJ; Zorn, SH	2
Gillis, RA; Hamosh, P; Hartley, B; Quest, JA; Taveira da Silva, AM	1
Löscher, W	1
Brunner, EA; Cheng, SC	1
Borsini, F; Giuliani, S; Meli, A	1
Friberg, L; Roland, PE	1
Drower, EJ; Hammond, DL	2
Depaulis, A; Liebeskind, JC; Morgan, MM	1
Zarkovsky, AM	1
Liebeskind, JC; Morgan, MM; Stein, C	1
Jørgensen, OS; Meier, E; Schousboe, A	1
Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM	1
Minchin, MC; Nutt, DJ	1
Jensen, MS; Lambert, JD	1
Arnt, J; Christensen, AV	1
Casey, DE; Gerlach, J; Hetmar, O; Kaldan, B; Korsgaard, S; Mikkelsen, LB	1
Forchetti, MC; Guidotti, A; Krogsgaard-Larsen, P; Moroni, F	1
Karobath, M; Supavilai, P	1
Persson, B	1
Chase, TN; Denaro, A; Foster, NL; Hare, TA; Tamminga, CA	1
Cross, AJ; Waddington, JL	1
Kelly, PA; McCulloch, J	2
Aaes-Jørgensen, T; Bøgesø, KP; Krogsgaard-Larsen, P; Mikkelsen, H; Schultz, B	1
Brehm, L; Krogsgaard-Larsen, P; Schaumburg, K	1
Falch, E; Krogsgaard-Larsen, P	1
Blavet, N; Clostre, F; DeFeudis, FV	1
Blavet, N; Clostre, F; De Feudis, FV	1
Dias Souza, J; Gillis, RA; Quest, JA; Williford, DJ	1
Curtis, DR; Hjeds, H; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ	1
Christensen, AV; Krogsgaard-Larsen, P; Svendsen, O	1
Blavet, N; DeFeudis, FV	1
Mondrup, K; Pedersen, E	1
Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ	1
Johnston, GA; Skerritt, JH	1
Costa, LG; Murphy, SD	1
Dafny, N; Reyes-Vázquez, C	1
Bank-Mikkelsen, OK; Valentin, N	1
Hoehn-Saric, R	1
Altmann, H; Dose, M; Emrich, HM; von Zerssen, D	1
Bjørndal, N; Christensson, E; Gerlach, J	1
Di Scala, G; Karli, P; Schmitt, P	1
DeFeudis, FV	1
Kjaer, M; Nielsen, H	1
Følsgård, S; Jacobsen, E; Lindeburg, T; Madsen, SM; Sillesen, H	1
DeFeudis, FV; Grognet, A; Hertz, F	3
Agnoli, A; Chase, TN; Denaro, A; Ruggieri, S; Tamminga, CA	1
Macdonald, RL; Skerritt, JH	1
Horton, R; Meldrum, B	1
Følsgård, S; Jacobsen, E; Kehlet, H; Lindeburg, T; Sillesen, H	1
Andree, T; Enna, SJ; Kendall, DA	1
Dam, M; Jensen, I; Petersen, HR	1
Cheney, DL; McGill, W; Murray, TF	1
Madsen, SM	1
Maugh, TH	1
Christensen, AV; Larsen, JJ	1
Buescher, HH; Hill, RC; Maurer, R; Roemer, D	1
Kuhar, MJ; London, ED; Palacios, JM; Rapoport, SI	1
Menon, MK	1
Aaes-Jørgensen, T; Bøgesø, KP; Jørgensen, A; Schultz, B	1
Hruska, RE; Walters, JR; Waszczak, BL	1

Reviews

3 review(s) available for gaboxadol and oxazoles

Article	Year
THIP, isoguvacine, isoguvacine oxide, and related GABA agonists. Advances in biochemical psychopharmacology, 1981, Volume: 29 Topics: Animals; Autoradiography; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Oxazoles; Pipecolic Acids; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution	1981
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure. Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1981, Volume: 35, Issue:5 Topics: Agaricales; Amanita; Animals; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Structural; Molecular Conformation; Muscimol; Nipecotic Acids; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism	1981
Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist. Pharmaceutisch weekblad. Scientific edition, 1982, Oct-22, Volume: 4, Issue:5 Topics: Analgesics; Animals; Brain; gamma-Aminobutyric Acid; Humans; Isoxazoles; Methylphenidate; Neurons; Oxazoles; Stereotyped Behavior; Synaptic Transmission	1982

Trials

7 trial(s) available for gaboxadol and oxazoles

Article	Year
GABA-agonist therapy for Alzheimer's disease. Clinical neuropharmacology, 1986, Volume: 9, Issue:3 Topics: Alzheimer Disease; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Isoxazoles; Middle Aged; Neuropsychological Tests; Oxazoles; Somatostatin	1986
The effect of tetrahydroisoxazolopyridinol (THIP) in tardive dyskinesia: a new gamma-aminobutyric acid agonist. Archives of general psychiatry, 1982, Volume: 39, Issue:9 Topics: Adult; Aged; Analgesics; Antipsychotic Agents; Blinking; Clinical Trials as Topic; Confusion; Dizziness; Dyskinesia, Drug-Induced; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Oxazoles; Parkinson Disease, Secondary; Placebos; Vomiting	1982
THIP treatment of Huntington's disease. Neurology, 1983, Volume: 33, Issue:5 Topics: Adult; Clinical Trials as Topic; Disability Evaluation; Double-Blind Method; Female; Homovanillic Acid; Humans; Huntington Disease; Isoxazoles; Male; Middle Aged; Oxazoles	1983
Respiratory effect of THIP, a GABA-agonistic analgesic, during halothane anaesthesia. Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:5 Topics: Adolescent; Adult; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Halothane; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Respiration	1983
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report. Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2 Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid	1983
THIP: a single-blind controlled trial in patients with epilepsy. Acta neurologica Scandinavica, 1983, Volume: 67, Issue:2 Topics: Adult; Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles	1983
Analgesic from mushrooms begins clinical trials. Science (New York, N.Y.), 1981, Apr-24, Volume: 212, Issue:4493 Topics: Analgesics; Clinical Trials as Topic; Humans; Isoxazoles; Oxazoles	1981

Other Studies

82 other study(ies) available for gaboxadol and oxazoles

Article	Year
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding. European journal of pharmacology, 1979, Oct-15, Volume: 58, Issue:4 Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug	1979
Does uptake limit the actions of GABA agonists in vivo? Experiments with muscimol, isoguvacine and THIP in cat spinal cord. Journal of neurochemistry, 1978, Volume: 31, Issue:6 Topics: Aminobutyrates; Animals; Biological Transport; Cats; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons; Nipecotic Acids; Oxazoles; Spinal Cord	1978
Modulation of tolerance to the GABAA agonist THIP by environmental cues. Behavioural brain research, 1990, Jan-01, Volume: 36, Issue:1-2 Topics: Animals; Anticonvulsants; Arousal; Association Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Tolerance; Exploratory Behavior; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxazoles; Receptors, GABA-A; Social Environment	1990
Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells. Journal of neurochemistry, 1990, Volume: 55, Issue:4 Topics: Animals; Anticonvulsants; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; Colchicine; Cycloheximide; Dactinomycin; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Monensin; Oxazoles; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Receptors, GABA-A	1990
GABAergic drugs and lordosis behavior in the female rat. Hormones and behavior, 1989, Volume: 23, Issue:3 Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Estradiol; Female; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Taurine	1989
Enzymic synthesis of two glucuronides of the hydroxyisoxazole GABA-agonist, THIP, and the in vivo glucuronidation of THIP in rat. Xenobiotica; the fate of foreign compounds in biological systems, 1989, Volume: 19, Issue:12 Topics: Animals; Chromatography, High Pressure Liquid; Glucuronates; Glucuronidase; Hydrolysis; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Oxazoles; Rabbits; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet	1989
Effects of GABA, THIP, and potassium on excitability of myelinated axons of isolated amphibian spinal roots. Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:6 Topics: Anesthetics; Animals; Axons; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Myelin Sheath; Oxazoles; Potassium; Rana catesbeiana; Spinal Cord	1989
Effect of gamma-aminobutyric acidA receptor agonists and antagonists on the release of enkephalin-containing peptides from dog adrenal gland. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1 Topics: Adrenal Medulla; Analgesics; Animals; Bicuculline; Catecholamines; Dogs; Electric Stimulation; Enkephalins; Female; Isoxazoles; Oxazoles; Receptors, GABA-A; Splanchnic Nerves	1987
Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus. Neuroscience letters, 1988, May-03, Volume: 87, Issue:3 Topics: Acetylcholine; Animals; Brain Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamus	1988
GABA-related drugs modulate the behavioral effects of lorazepam. Psychopharmacology, 1988, Volume: 95, Issue:1 Topics: Animals; Behavior, Animal; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Lorazepam; Male; Oxazoles; Receptors, GABA-A; Saimiri	1988
Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1987, Volume: 5, Issue:3 Topics: Animals; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors	1987
GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1988, Volume: 6, Issue:2 Topics: Animals; Cells, Cultured; Cerebellar Cortex; Isoxazoles; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A	1988
Excitatory amino acids: studies on the biochemical and chemical stability of ibotenic acid and related compounds. Journal of neurochemistry, 1985, Volume: 45, Issue:3 Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Decarboxylation; Glutamates; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Ibotenic Acid; Isoxazoles; Liver; Mice; Muscimol; Oxazoles; Pregnancy Proteins	1985
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility. Experimental neurology, 1989, Volume: 104, Issue:1 Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures	1989
A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen. Neuropharmacology, 1985, Volume: 24, Issue:3 Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Oxazoles; Postural Balance; Receptors, GABA-A	1985
Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analogue of the GABA agonist THIP. Journal of medicinal chemistry, 1985, Volume: 28, Issue:8 Topics: Animals; Anticonvulsants; Cerebellum; Electrophysiology; Female; Isoxazoles; Male; Mice; Muscimol; Oxazoles; Rats; Receptors, GABA-A	1985
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist. Physiology & behavior, 1985, Volume: 35, Issue:3 Topics: Aggression; Animals; Bicuculline; Brain; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission	1985
Autoradiographic localization of binding sites for the gamma-aminobutyric acid analogues 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP)isoguvacine and baclofen on cultured neurons of rat cerebellum and spinal cord. Neuroscience letters, 1985, Oct-24, Volume: 61, Issue:1-2 Topics: Animals; Animals, Newborn; Autoradiography; Baclofen; Binding Sites; Cells, Cultured; Cerebellum; Fetus; Isonicotinic Acids; Isoxazoles; Oxazoles; Rats; Receptors, GABA-A; Spinal Cord	1985
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2 Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Nervous System; Oxazoles; Receptors, GABA-A; Seizures	1986
GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors. Neurochemical research, 1986, Volume: 11, Issue:4 Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Intracellular Membranes; Isoxazoles; Kinetics; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A	1986
Glycine antagonists structurally related to 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin-3-ol inhibit binding of [3H]strychnine to rat brain membranes. Journal of neurochemistry, 1986, Volume: 47, Issue:3 Topics: Animals; Anions; Binding, Competitive; Cell Membrane; Chlorides; Choline; GABA Antagonists; Glycine; Isoxazoles; Male; Medulla Oblongata; Oxazoles; Pons; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Sodium Chloride; Strychnine	1986
[Changes in the ligand affinity of benzodiazepine receptors in the presence of 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP)]. Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:2 Topics: Animals; Brain; Depression, Chemical; Dose-Response Relationship, Drug; Flunitrazepam; In Vitro Techniques; Isoxazoles; Ligands; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A	1987
Effect of THIP and SL 76002, two clinically experimented GABA-mimetic compounds, on anterior pituitary GABA receptors and prolactin secretion in the rat. Life sciences, 1987, Mar-02, Volume: 40, Issue:9 Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Female; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Male; Muscimol; Ovariectomy; Oxazoles; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A	1987
Hypnotic action of pentobarbital in mice: a possible mechanism. Experimental neurology, 1987, Volume: 97, Issue:1 Topics: Animals; Baclofen; Bicuculline; Isoxazoles; Male; Mice; Oxazoles; Pentobarbital; Receptors, GABA-A; Reflex; Sleep	1987
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission. Neuropharmacology, 1987, Volume: 26, Issue:5 Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists; Isoxazoles; Male; Mice; Oxazoles; Pain; Physostigmine; Synaptic Transmission	1987
Respiratory depressant effects of GABA alpha- and beta-receptor agonists in the cat. Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 62, Issue:6 Topics: Animals; Baclofen; Bicuculline; Cats; Female; Heart; Injections, Intravenous; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, GABA-A; Respiration	1987
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4 Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid	1986
Inducing anesthesia with a GABA analog, THIP. Anesthesiology, 1985, Volume: 63, Issue:2 Topics: Analgesics; Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; gamma-Aminobutyric Acid; Isoxazoles; Ketamine; Male; Mice; Midazolam; Oxazoles; Rats; Rats, Inbred Strains; Sodium Oxybate; Time Factors	1985
Functional responses to baclofen and 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (THIP) in rats repeatedly treated with desipramine. Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:1 Topics: Analgesics; Animals; Baclofen; Behavior, Animal; Body Temperature; Desipramine; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains	1988
The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1988, Volume: 8, Issue:3 Topics: Adolescent; Adult; Behavior; Carotid Arteries; Cerebrovascular Circulation; Dominance, Cerebral; Electroencephalography; gamma-Aminobutyric Acid; Humans; Injections, Intra-Arterial; Isoxazoles; Middle Aged; Neural Inhibition; Oxazoles; Synapses	1988
Gamma-aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development. Journal of neurochemistry, 1988, Volume: 51, Issue:1 Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasm; Endoplasmic Reticulum; gamma-Aminobutyric Acid; Golgi Apparatus; Isoxazoles; Microscopy, Electron; Oxazoles; Rats; Rats, Inbred Strains	1988
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat. Brain research, 1988, May-31, Volume: 450, Issue:1-2 Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds	1988
GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat. Brain research, 1987, Dec-15, Volume: 436, Issue:2 Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Periaqueductal Gray; Picrotoxin; Raphe Nuclei; Rats; Rats, Inbred Strains	1987
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam. Neuropharmacology, 1987, Volume: 26, Issue:7A Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium	1987
Intrathecal administration of pentobarbital and THIP: evidence for descending excitatory and inhibitory modulation of a spinal reflex. Proceedings of the Western Pharmacology Society, 1987, Volume: 30 Topics: Analgesics; Animals; Efferent Pathways; Injections, Spinal; Isoxazoles; Male; Neural Inhibition; Oxazoles; Pentobarbital; Rats; Rats, Inbred Strains; Reflex; Spinal Cord	1987
Effect of repeated treatment with a gamma-aminobutyric acid receptor agonist on postnatal neural development in rats. Journal of neurochemistry, 1987, Volume: 49, Issue:5 Topics: Animals; Antigens, Surface; Brain; Cell Adhesion; Cell Adhesion Molecules; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Isoxazoles; Nerve Tissue Proteins; Neurons; Organ Size; Oxazoles; Rats; Rats, Inbred Strains	1987
The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen. Brain research, 1985, Jul-15, Volume: 338, Issue:2 Topics: Analgesics; Animals; Baclofen; Central Nervous System; Clonidine; Cordotomy; Isoxazoles; Male; Mice; Morphine; Oxazoles; Oxotremorine	1985
Blockade of "antiabsence" activity of sodium valproate by THIP in rats with petit mal-like seizures. Comparison with ethosuximide. Journal of neural transmission, 1985, Volume: 63, Issue:2 Topics: Animals; Epilepsy, Absence; Ethosuximide; GABA Antagonists; Injections; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Valproic Acid	1985
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist. Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:4 Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sensory Thresholds	1984
Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones. Neuropharmacology, 1984, Volume: 23, Issue:12A Topics: Animals; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Mice; Midazolam; Neurons; Oxazoles; Piperidines; Receptors, GABA-A	1984
Differential reversal by scopolamine and THIP of the antistereotypic and cataleptic effects of neuroleptics. European journal of pharmacology, 1981, Jan-05, Volume: 69, Issue:1 Topics: Amphetamine; Animals; Antipsychotic Agents; Catalepsy; Humans; Isoxazoles; Male; Oxazoles; Rats; Scopolamine; Stereotyped Behavior	1981
Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat. The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:10 Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Time Factors	1982
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid. Neuroscience letters, 1980, Oct-02, Volume: 19, Issue:3 Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium	1980
Cardiovascular effects of THIP in the rat. The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:11 Topics: Animals; Blood Pressure; Heart Rate; Hemodynamics; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Rats, Inbred Strains	1983
Therapeutic failure of GABA agonist treatment in Huntington's disease. Neurology, 1984, Volume: 34, Issue:5 Topics: gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoxazoles; Oxazoles	1984
Heterogeneous depression of glucose utilization in the caudate nucleus by GABA agonists. Brain research, 1981, Mar-30, Volume: 209, Issue:2 Topics: Animals; Autoradiography; Blood Glucose; Caudate Nucleus; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A	1981
The binding of the GABA agonist [3H]THIP to rat brain synaptic membranes. Journal of neurochemistry, 1982, Volume: 38, Issue:4 Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Tritium	1982
Orally administered THIP inhibits food intake in the rat. Behavioral and neural biology, 1982, Volume: 34, Issue:1 Topics: Administration, Oral; Animals; Bicuculline; Dose-Response Relationship, Drug; Eating; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A	1982
THIP inhibits feeding behavior in fasted rats. Psychopharmacology, 1982, Volume: 76, Issue:1 Topics: Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Eating; Food Deprivation; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A	1982
Central cardiovascular effects produced by the GABA receptor agonist drug, THIP. Neuropharmacology, 1982, Volume: 21, Issue:6 Topics: Animals; Autonomic Nervous System; Bicuculline; Blood Pressure; Brain; Cats; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A	1982
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine. Journal of neurochemistry, 1982, Volume: 39, Issue:5 Topics: Animals; Cats; gamma-Aminobutyric Acid; Glycine; Interneurons; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Structure-Activity Relationship	1982
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat. Physiology & behavior, 1982, Volume: 29, Issue:5 Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine	1982
The acute effect of the GABA-agonist, THIP, on proprioceptive and flexor reflexes in spastic patients. Acta neurologica Scandinavica, 1983, Volume: 67, Issue:1 Topics: Adult; Female; Humans; Isoxazoles; Male; Mechanoreceptors; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Oxazoles; Paraplegia; Proprioception; Reaction Time; Receptors, Cell Surface; Receptors, GABA-A; Reflex, Monosynaptic; Reflex, Stretch	1983
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. Journal of medicinal chemistry, 1983, Volume: 26, Issue:6 Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes	1983
Diazepam stimulates the binding of GABA and muscimol but not THIP to rat brain membranes. Neuroscience letters, 1983, Aug-08, Volume: 38, Issue:3 Topics: Analgesics; Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A	1983
Antinociceptive effect of the GABAmimetic 4,5,6,7-tetrahydroisoxazolo [5, 4-c]pyridin-3-ol (THIP): chronic treatment increases alpha-2 adrenoceptors in the mouse brain. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:2 Topics: Analgesics; Animals; Brain Chemistry; Clonidine; Drug Tolerance; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, GABA-A	1984
Microiontophoretically applied THIP effects upon nociceptive responses of neurons in medial thalamus. Applied neurophysiology, 1983, Volume: 46, Issue:5-6 Topics: Animals; Evoked Potentials; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Spinothalamic Tracts; Synaptic Transmission; Tail; Thalamic Nuclei	1983
Effects of THIP on chronic anxiety. Psychopharmacology, 1983, Volume: 80, Issue:4 Topics: Adult; Anxiety Disorders; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Psychiatric Status Rating Scales	1983
Methylphenidate, apomorphine, THIP, and diazepam in monkeys: dopamine-GABA behavior related to psychoses and tardive dyskinesia. Psychopharmacology, 1984, Volume: 82, Issue:1-2 Topics: Animals; Apomorphine; Chlorocebus aethiops; Diazepam; Dopamine; Drug Interactions; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Isoxazoles; Male; Methylphenidate; Motor Activity; Oxazoles; Psychoses, Substance-Induced	1984
Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold. European journal of pharmacology, 1984, Aug-03, Volume: 103, Issue:1-2 Topics: Animals; Baclofen; Injections, Spinal; Isoxazoles; Male; Muscimol; Muscle Hypotonia; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds	1984
Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation. Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2 Topics: Analgesics; Animals; Baclofen; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Motor Activity; Muscimol; Oxazoles; Physical Stimulation; Rats; Rats, Inbred Strains; Superior Colliculi; Touch	1983
Anorexic and analgesic actions of THIP. Advances in biochemical psychopharmacology, 1983, Volume: 37 Topics: Analgesics; Animals; Appetite Depressants; Behavior, Animal; Benzoquinones; Drug Interactions; Feeding Behavior; Isoxazoles; Male; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time	1983
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study. British journal of clinical pharmacology, 1983, Volume: 16, Issue:5 Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Oxazoles; Pain	1983
Pharmacokinetics of the gamma-aminobutyric acid agonist THIP (Gaboxadol) following intramuscular administration to man, with observations in dog. Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:5 Topics: Absorption; Adult; Animals; Dogs; Humans; Injections, Intramuscular; Isoxazoles; Kinetics; Male; Models, Biological; Oxazoles	1983
Comparison of the analgesic actions of THIP and morphine. General pharmacology, 1983, Volume: 14, Issue:6 Topics: Analgesics; Animals; Atropine; Benzoquinones; Bicuculline; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Morphine; Naloxone; Oxazoles; Quinones; Reaction Time	1983
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist. Physiology & behavior, 1983, Volume: 30, Issue:3 Topics: Aggression; Animals; Arousal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Injections, Intraventricular; Isoxazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time	1983
State of DA/ACh balance after chronic treatment with haloperidol and with THIP in rats. Advances in neurology, 1984, Volume: 40 Topics: Acetylcholine; Animals; Apomorphine; Atropine; Behavior, Animal; Brain; Dopamine; Haloperidol; Isoxazoles; Male; Oxazoles; Physostigmine; Rats; Rats, Inbred Strains	1984
Diazepam enhances the action but not the binding of the GABA analog, THIP. Brain research, 1984, Apr-09, Volume: 297, Issue:1 Topics: Animals; Brain; Chlorides; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ganglia, Spinal; Isoxazoles; Membrane Potentials; Mice; Oxazoles; Rats; Spinal Cord	1984
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy. European journal of pharmacology, 1980, Feb-08, Volume: 61, Issue:3 Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; Mice; Mice, Inbred DBA; Myoclonus; Oxazoles; Papio; Photic Stimulation; Seizures; Time Factors	1980
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist. Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:1 Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazoles; Male; Oxazoles; Pain; Prolactin; Random Allocation; Respiration; Sensory Thresholds	1983
THIP analgesia: cross tolerance with morphine. Life sciences, 1983, May-09, Volume: 32, Issue:19 Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Models, Biological; Morphine; Nipecotic Acids; Oxazoles; Pyrones	1983
A comparison of the analgesic activities of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) and 6-chloro-2[1-piperazinyl]pyrazine (MK 212). European journal of pharmacology, 1983, Jun-03, Volume: 90, Issue:2-3 Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Oxazoles; Pyrazines; Time Factors	1983
Quantitative determination of the gamma-aminobutyric acid agonist, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, in serum by high-performance liquid chromatography. Journal of chromatography, 1983, May-13, Volume: 274 Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dogs; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Oxazoles; Papio; Rats; Spectrophotometry, Ultraviolet	1983
Effects of the putative GABAergic agonists, muscimol and THIP, upon local cerebral glucose utilisation. Journal of neurochemistry, 1982, Volume: 39, Issue:3 Topics: Analgesics; Animals; Brain; Deoxy Sugars; Deoxyglucose; gamma-Aminobutyric Acid; Glycolysis; Isoxazoles; Male; Muscimol; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains	1982
Differentiation of the analgesic effects of THIP and morphine using three mouse strains. Drug and alcohol dependence, 1982, Volume: 9, Issue:3 Topics: Analgesics; Animals; GABA Antagonists; Hot Temperature; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles	1982
Comparison of the antinociceptive actions of THIP and morphine. Pharmacological research communications, 1982, Volume: 14, Issue:10 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Reaction Time; Species Specificity	1982
Antinociceptive and anticonvulsive effect of THIP, a pure GABA agonist. Polish journal of pharmacology and pharmacy, 1982, Volume: 34, Issue:1-3 Topics: Analgesics; Animals; Anticonvulsants; Benzoquinones; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time	1982
Analgesic properties of the GABA-mimetic THIP. European journal of pharmacology, 1981, Jan-16, Volume: 69, Issue:2 Topics: Analgesics; Animals; Arthritis, Experimental; Baclofen; Electric Stimulation; Isoxazoles; Macaca mulatta; Mice; Morphine; Muscimol; Oxazoles; Reaction Time	1981
Increases and decreases in local cerebral glucose utilization in response to GABA agonists. European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3 Topics: Animals; Brain; gamma-Aminobutyric Acid; Glucose; Isoxazoles; Male; Muscimol; Oxazoles; Rats	1981
Paradoxical blockade of a muscimol response by THIP, a GABA agonist and also by GABA-transaminase inhibitors. Neuropharmacology, 1981, Volume: 20, Issue:12A Topics: 4-Aminobutyrate Transaminase; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Myoclonus; Oxazoles; Time Factors; Transaminases	1981
Preliminary studies on the absorption, distribution, metabolism, and excretion of THIP in animal and man using 14C-labelled compound. Acta pharmacologica et toxicologica, 1981, Volume: 49, Issue:2 Topics: Absorption; Adult; Animals; Brain; Carbon Radioisotopes; Chromatography, Thin Layer; Half-Life; Humans; Hydrolysis; Isoxazoles; Male; Mice; Mice, Inbred Strains; Middle Aged; Oxazoles; Rats; Rats, Inbred Strains; Tissue Distribution	1981
GABAergic actions of THIP in vivo and vitro: a comparison with muscimol and GABA. European journal of pharmacology, 1980, Jul-11, Volume: 65, Issue:1 Topics: Animals; Binding Sites; Brain; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Oxazoles; Rats; Substantia Nigra	1980