gaboxadol has been researched along with gamma-aminobutyric acid in 214 studies
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 117 (54.67) | 18.7374 |
| 1990's | 41 (19.16) | 18.2507 |
| 2000's | 29 (13.55) | 29.6817 |
| 2010's | 27 (12.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ | 1 |
| Brehm, L; Falch, E; Frølund, B; Hansen, AB; Kristiansen, U; Krogsgaard-Larsen, P | 1 |
| Chebib, M; Johnston, GA | 1 |
| Barlow, RL; Bloomquist, JR; Carlier, PR; Chow, ES | 1 |
| Fruttero, R; Gasco, A; Hansen, SL; Johansen, TN; Kristiansen, U; Larsen, OM; Lolli, ML; Madsen, K; Nielsen, B; Rolando, B; Wellendorph, P | 1 |
| Bang-Andersen, B; Ebert, B; Frølund, B; Hansen, CP; Jensen, AA; Kristiansen, U; Krogsgaard-Larsen, P; Larsen, M; Liljefors, T; Madsen, C; Nielsen, B | 1 |
| Chebib, M; Hanrahan, JR; Hibbs, DE; Johnston, GA; Kim, HL; Kumar, RJ; Salam, NK | 1 |
| Balle, T; Bergmann, R; Frydenvang, K; Frølund, B; Jensen, AA; Jørgensen, CG; Kehler, J; Kristensen, J; Kristiansen, U; Møller, HA; Nielsen, B; Petersen, JG | 1 |
| Polc, P | 1 |
| Karobath, M; Lippitsch, M | 1 |
| Curtis, DR; Johnston, GA; Lodge, D | 1 |
| Aprison, MH; Lipkowitz, KB | 1 |
| Johnston, GA | 1 |
| Amit, Z; Robidoux, J; Smith, BR | 1 |
| Amit, Z; Boyle, AE; Smith, BR | 1 |
| Ebbesson, SO; Erdö, SL; Hofmann, MH; Malz, CR; Meyer, DL | 1 |
| Bonaventure, N; Jardon, B | 1 |
| Belhage, B; Hansen, GH; Schousboe, A | 1 |
| Ramsey, VA; Rosenberg, HC; Tietz, EI | 1 |
| Barolet, AW; Morris, ME | 1 |
| Diemer, NH; Johansen, FF | 1 |
| Agmo, A; Gutiérrez, M; Guzmán, M; Pruneda, R | 1 |
| Fromm, GH; Mukawa, J; Nakata, M | 1 |
| Heinricher, MM; Kaplan, HJ | 1 |
| Corbett, R; Cornfeldt, M; Dunn, RW; Fielding, S | 1 |
| Boelen, MK; Chubb, IW; Dowton, M; Morgan, IG; Wellard, J | 1 |
| Hablitz, JJ; Mistry, DK | 1 |
| Catt, KJ; Stojilković, SS; Virmani, MA | 1 |
| Belhage, B; Hansen, GH; Meier, E; Schousboe, A | 3 |
| Balcar, VJ; Dreher, B | 1 |
| Michler, A | 1 |
| Hicks, TP; Kaneko, T | 1 |
| Bonaventure, N; Jardon, B; Kim, MS; Yucel, YH | 1 |
| Amenta, F; Erdö, SL; Mione, MC; Wolff, JR | 1 |
| Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M | 1 |
| Agmo, A; Paredes, R; Soria, P | 1 |
| Erdö, SL; Michler, A | 1 |
| Liske, S; Morris, ME | 3 |
| Karlsson, G; Olpe, HR | 1 |
| Bapna, JS; Ramaswamy, S; Suthakaran, C | 1 |
| Pooler, GW; Steward, EG | 1 |
| Cosi, C; Wood, PL | 1 |
| Spealman, RD; Wettstein, JG | 1 |
| Bitran, D; Leipheimer, RE; McQuade, DB; Miller, SA; Sachs, BD | 1 |
| Beani, L; Bianchi, C; Tanganelli, S | 1 |
| Meldrum, BS | 1 |
| Bruno, G; Chase, TN; Cox, C; Fedio, P; Foster, N; Gillespie, M; Hare, TA; Mohr, E; Tamminga, C | 1 |
| Andersson, U; Häggström, JE | 1 |
| Bagri, A; Di Scala, G; Sandner, G | 1 |
| Karobath, M; Supavilai, P | 2 |
| Iversen, LL; Wong, EH | 1 |
| Chweh, AY; Kupferberg, HJ; Swinyard, EA; Wolf, HH | 1 |
| Gianutsos, G; Suzdak, PD | 2 |
| Agmo, A; Paredes, R | 1 |
| Löscher, W; Schwark, WS | 1 |
| Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Nielsen, L | 1 |
| Depaulis, A; Vergnes, M | 3 |
| Bristow, DR; Watling, KJ | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA | 1 |
| Chweh, AY; Lin-Michell, E; Swinyard, EA | 1 |
| Allan, AM; Harris, RA | 1 |
| Ciesielski, L; Gobaille, S; Mandel, P; Molina, V | 1 |
| Falch, E; Hjeds, H; Krogsgaard-Larsen, P | 1 |
| Dafny, N; Enna, SJ; Reyes-Vazquez, C | 1 |
| Apud, JA; Masotto, C; Racagni, G | 1 |
| Alphs, LD; Ferraro, TN; Hare, TA; Lafferman, J; Tamminga, CA; Thaker, GK | 1 |
| Audi, EA; Graeff, FG | 1 |
| Lindgren, S | 1 |
| Zharkovskaia, TA; Zharkovskiĭ, AM | 1 |
| DaSilva, AM; Gatti, PJ; Gillis, RA | 1 |
| Chapman, AG | 1 |
| Löscher, W | 2 |
| Brunner, EA; Cheng, SC | 1 |
| Friberg, L; Roland, PE | 1 |
| Drower, EJ; Hammond, DL | 1 |
| Depaulis, A; Liebeskind, JC; Morgan, MM | 1 |
| Pelley, KA; Vaught, JL | 1 |
| Zarkovsky, AM | 1 |
| Jørgensen, OS; Meier, E; Schousboe, A | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Ford, I; Kelly, PA; McCulloch, J | 1 |
| Bennett, JP; Cruz, CJ; Ferrari, MB | 1 |
| Beart, PM; Lloyd, KG; Scatton, B | 1 |
| Sawynok, J | 1 |
| Ben-Ari, Y; Cherubini, E; Rovira, C | 1 |
| Meldrum, B | 1 |
| Maksay, G; Ticku, MK | 2 |
| Jensen, MS; Lambert, JD | 1 |
| Forchetti, MC; Guidotti, A; Krogsgaard-Larsen, P; Moroni, F | 1 |
| Drejer, J; Meier, E; Schousboe, A | 1 |
| Cross, AJ; Waddington, JL | 1 |
| Benson, DI; Klepner, CA; Squires, RF | 1 |
| Krogsgaard-Larsen, P | 1 |
| Aaes-Jørgensen, T; Bøgesø, KP; Krogsgaard-Larsen, P; Mikkelsen, H; Schultz, B | 1 |
| Carmona, E; Gomes, C; Trolin, G | 1 |
| Brehm, L; Krogsgaard-Larsen, P; Schaumburg, K | 1 |
| Falch, E; Krogsgaard-Larsen, P | 1 |
| Blavet, N; Clostre, F; De Feudis, FV | 1 |
| Wood, PL | 1 |
| Curtis, DR; Hjeds, H; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ | 1 |
| Dutton, GR; Freedman, EG; Pearce, BR | 1 |
| Breese, GR; Frye, GD | 1 |
| Christensen, AV; Krogsgaard-Larsen, P; Svendsen, O | 1 |
| Blavet, N; DeFeudis, FV | 1 |
| Breese, GR; Frye, GD; McCown, TJ | 1 |
| Madtes, P; Redburn, DA | 1 |
| Johnston, GA; Skerritt, JH | 1 |
| Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ | 1 |
| Deisz, RA; Dose, M | 1 |
| Bloch, R; Bousquet, P; Feldman, J; Schwartz, J | 1 |
| Dafny, N; Reyes-Vázquez, C | 1 |
| Bjørndal, N; Casey, DE; Christensson, E; Gerlach, J | 1 |
| Frey, HH; Löscher, W; Reiche, R; Schultz, D | 1 |
| Altmann, H; Dose, M; Emrich, HM; von Zerssen, D | 1 |
| Hare, TA; Tamminga, CA; Thaker, GK | 1 |
| Bjørndal, N; Christensson, E; Gerlach, J | 1 |
| Di Scala, G; Karli, P; Schmitt, P | 2 |
| Fariello, RG; Golden, GT | 1 |
| Baumeister, AA; Frye, GD | 1 |
| Bond, A; Neal, H | 1 |
| Mueller, AL; Schwartzkroin, PA; Taube, JS | 1 |
| Horton, R; Meldrum, B | 1 |
| Coward, DM | 1 |
| Madsen, SM | 1 |
| Kelly, PA; McCulloch, J | 1 |
| Cagiano, R; Cuomo, V; Mocchetti, I; Racagni, G | 1 |
| Alger, BE; Nicoll, RA | 1 |
| DeFeudis, FV; Grognet, A; Hertz, F | 1 |
| Christensen, AV; Larsen, JJ | 1 |
| Kuhar, MJ; London, ED; Palacios, JM; Rapoport, SI | 1 |
| Magelund, G; Scheel-Krüger, J | 1 |
| Ashton, D; Geerts, R; Leysen, JE; Waterkeyn, C | 1 |
| Menon, MK | 1 |
| Clark, WG; Menon, MK; Vivonia, C | 1 |
| Hruska, RE; Walters, JR; Waszczak, BL | 1 |
| Walters, JR; Waszczak, BL | 1 |
| Delorey, TM; Endo, S; Huh, KH; Olsen, RW | 1 |
| Garant, DS; Moshé, SL; Sperber, EF; Xu, SG | 1 |
| Ebert, B; Kemp, JA; Krogsgaard-Larsen, P; Wafford, KA; Whiting, PJ | 1 |
| Anderson, CA; Faingold, CL; Randall, ME | 1 |
| Kim, HY; Olsen, RW; Sapp, DW; Tobin, AJ | 1 |
| Barnes, EM; Calkin, PA | 1 |
| Batini, C; Billard, JM; Vigot, R | 1 |
| Bapna, JS; Ramaswamy, S; Thirugnanasambantham, P; Viswanathan, S | 1 |
| Barnes, EM; Tehrani, MH | 1 |
| Morishita, W; Sastry, BR | 1 |
| Baylis, HA; Buckingham, SD; Hosie, AM; Matsuda, K; Sattelle, DB; Squire, MD | 1 |
| Alger, BE; Kirov, SA; Lenz, RA; Martin, LA; Morishita, W; Pitler, TA | 1 |
| Matsutani, S; Yamamoto, N | 1 |
| Aleo, MD; Miller, GW; Schnellmann, RG; Waters, SL | 1 |
| Bedingfield, JB; Calder, LD; Karler, R; Thai, DK | 1 |
| Dzubay, JA; Jones, MV; Sahara, Y; Westbrook, GL | 1 |
| Burgard, EC; Haas, KF; Macdonald, RL | 1 |
| de Almeida, OM; de Mello, FG; de Mello, MC; Gardino, PF; Hokoç, JN; Loureiro dos Santos, NE; Yamasaki, EN | 1 |
| Brünig, I; Fritschy, JM; Studler, B | 1 |
| Platt, B; White, AM | 1 |
| Birnir, B; Ebert, B; Lindquist, CE | 1 |
| Birnir, B; Lindquist, CE; Smith, M | 1 |
| Blednov, YA; Boehm, SL; Harris, RA; Peden, L | 1 |
| Barry, PH; Carland, JE; Chebib, M; Johnston, GA; Moorhouse, AJ | 1 |
| France, CP; McMahon, LR | 1 |
| Ebert, B; Stórustovu, SI | 1 |
| Jia, H; Qu, CL; Tang, JS | 1 |
| Davies, M; Derry, JM; Dunn, SM; Paulsen, IM | 1 |
| Allgaier, C; Rassler, C; Strecker, K; Wegner, F; Wohlfarth, K | 1 |
| Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M | 1 |
| Park, JB; Skalska, S; Son, S; Stern, JE | 1 |
| Brust, P; Deuther-Conrad, W; Ebert, B; Friemel, A; Hutson, PH; Nieber, K | 1 |
| Boehm, SL; Goldfarb, KJ; Linsenbardt, DN; Moore, EM; Serio, KM; Stepanovska, S | 1 |
| Korpi, ER; Linden, AM; Lüddens, H; Möykkynen, T; Rabe, H; Ranna, M; Saarelainen, KS; Sinkkonen, ST; Uusi-Oukari, M | 1 |
| Harrison, NL; Keramidas, A | 1 |
| Hutson, PH; McDonald, LM; Sheppard, WF; Sohal, B; Staveley, SM; Tattersall, FD | 1 |
| Dósa, Z; Drasbek, KR; Jensen, K; Vardya, I | 1 |
| Amar, M; Baux, G; Fossier, P; Le Roux, N; Moreau, A | 1 |
| Akabas, MH; Dannhardt, G; Debus, F; Dieler, S; Jansen, M; Lüddens, H; Rabe, H; Strehle, A | 1 |
| Kositsyn, NS; Shul'gina, GI; Zyablitseva, EA | 1 |
| Gartside, SE; Griffith, NC; Ingram, CD; Kaura, V | 1 |
| Baur, R; Kaur, KH; Sigel, E | 1 |
| Henningsen, K; Holm, MM; Jayatissa, MN; Jensen, K; Nieto-Gonzalez, JL; Vardya, I; Wiborg, O | 1 |
| Ebert, B; Mortensen, M; Smart, TG; Wafford, K | 1 |
| Corbin, JG; Huntsman, MM; Kaufmann, WE; Martin, BS; Olmos-Serrano, JL; Paluszkiewicz, SM | 1 |
| Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J | 1 |
| Mozrzymas, JW; Urban-Ciecko, J | 1 |
| Bonin, RP; De Koninck, Y; Eng, DG; Labrakakis, C; Orser, BA; Whissell, PD | 1 |
| Burns, MP; Corbin, JG; Olmos-Serrano, JL | 1 |
| Barberis, A; Benfenati, F; Cancedda, L; Fiumelli, H; Succol, F | 1 |
| Gielen, MC; Lumb, MJ; Smart, TG | 1 |
| Egawa, K; Fukuda, A; Inoue, K; Kishino, T; Kitagawa, K; Kitagawa, M; Saitoh, S; Takayama, C; Takayama, M | 1 |
| Chen, G; Jiang, D; Kong, S; Pitre, A; Sun, Y; Wang, Y; Wu, Z | 1 |
| Karakossian, MH; Meera, P; Otis, TS; Santhakumar, V | 1 |
| Brozoski, TJ; Cai, R; Caspary, DM; Kalappa, BI; Ling, LL | 1 |
| Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG | 1 |
| Dvorzhak, A; Grantyn, R; Semtner, M; Wójtowicz, AM | 1 |
| Brazhe, A; Jensen, K; Jessen, SB; Lauritzen, M; Lind, BL; Mathiesen, C; Thomsen, K | 1 |
| Baldelli, P; Benfenati, F; Ferrea, E; Greco, B; Medrihan, L | 1 |
| Lingford-Hughes, A; Muthukumaraswamy, S; Myers, J; Nutt, D; Papadopoulos, A; Wilson, S | 1 |
| Babateen, O; Bhandage, A; Birnir, B; Forsberg Nilsson, K; Jin, Z; Korol, SV; Smits, A; Uhrbom, L; Westermark, B | 1 |
| Kuver, A; Smith, SS | 1 |
| Holm, R; Lagunas, C; Nielsen, CU; Plum, J; Rasmussen, RN | 1 |
| Absalom, NL; Ahring, PK; Chebib, M; Hanrahan, JR; Lee, HJ; van Nieuwenhuijzen, P | 1 |
| Cai, J; Chen, RX; Liao, FF; Liu, FY; Wan, Y; Wang, J; Xu, FQ; Yi, M; Zhang, C; Zhang, Y | 1 |
| Babapour, V; Hashemzadeh, M; Panahi, N; Zendehdel, M | 1 |
| Alabed, S; Bergman, H; Latifeh, Y; Mohammad, HA | 1 |
12 review(s) available for gaboxadol and gamma-aminobutyric acid
| Article | Year |
|---|---|
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Ion Channels; Ligands; Receptors, GABA; Receptors, GABA-A; Structure-Activity Relationship | 2000 |
GABAA agonists as targets for drug development.
Topics: Acetates; Acrylates; Amines; Analgesics; Anthelmintics; Anticonvulsants; Bicuculline; Computer Simulation; Cyclohexanecarboxylic Acids; Cyclopentanes; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Molecular Weight; Receptors, GABA-A | 1992 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; Hypoxia; Imidazoles; Isoxazoles; Mice; Mice, Inbred DBA; Muscimol; Myoclonus; Neurotransmitter Agents; Papio; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Heterocyclic analogues of GABA: chemistry, molecular pharmacology and therapeutic aspects.
Topics: Analgesics; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Nipecotic Acids; Receptors, GABA-A | 1985 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid | 1986 |
Inhibitors of the GABA uptake systems.
Topics: Animals; Astrocytes; Biological Transport; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoxazoles; Muscimol; Neuroglia; Neurons; Nipecotic Acids; Receptors, Neurotransmitter; Structure-Activity Relationship; Synapses; Synaptosomes | 1980 |
THIP, isoguvacine, isoguvacine oxide, and related GABA agonists.
Topics: Animals; Autoradiography; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Oxazoles; Pipecolic Acids; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution | 1981 |
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.
Topics: Agaricales; Amanita; Animals; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Structural; Molecular Conformation; Muscimol; Nipecotic Acids; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism | 1981 |
Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.
Topics: Analgesics; Animals; Brain; gamma-Aminobutyric Acid; Humans; Isoxazoles; Methylphenidate; Neurons; Oxazoles; Stereotyped Behavior; Synaptic Transmission | 1982 |
Molecular pharmacology of the GABA receptors and GABA agonists.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Humans; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism; Synapses | 1983 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin | 1983 |
Gamma-aminobutyric acid agonists for antipsychotic-induced tardive dyskinesia.
Topics: Antipsychotic Agents; Baclofen; Dyskinesia, Drug-Induced; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Placebos; Randomized Controlled Trials as Topic; Valproic Acid | 2018 |
5 trial(s) available for gaboxadol and gamma-aminobutyric acid
| Article | Year |
|---|---|
GABA-agonist therapy for Alzheimer's disease.
Topics: Alzheimer Disease; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Isoxazoles; Middle Aged; Neuropsychological Tests; Oxazoles; Somatostatin | 1986 |
Brain gamma-aminobutyric acid abnormality in tardive dyskinesia. Reduction in cerebrospinal fluid GABA levels and therapeutic response to GABA agonist treatment.
Topics: Adult; Aminocaproates; Brain; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Receptors, GABA-A; Schizophrenia; Vigabatrin | 1987 |
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report.
Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid | 1983 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin | 1983 |
Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers.
Topics: Adult; Brain; Brain Waves; Cross-Over Studies; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Magnetoencephalography; Male; Nipecotic Acids; Pyridines; Rest; Single-Blind Method; Synapses; Tiagabine; Young Adult; Zolpidem | 2015 |
198 other study(ies) available for gaboxadol and gamma-aminobutyric acid
| Article | Year |
|---|---|
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes | 1983 |
Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.
Topics: Animals; Cells, Cultured; Cerebral Cortex; GABA-A Receptor Agonists; Isoxazoles; Magnetic Resonance Spectroscopy; Mice; Neurons; Rats; Rats, Sprague-Dawley | 1995 |
Discovery of non-zwitterionic GABA(A) receptor full agonists and a superagonist.
Topics: Amides; Animals; Binding, Competitive; Chlorides; Dimerization; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ligands; Mice; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes | 2002 |
Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.
Topics: Animals; Astrocytes; Binding, Competitive; Cell Line; Cells, Cultured; Cerebral Cortex; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Mice; Neurons; Oxadiazoles; Patch-Clamp Techniques; Rats; Structure-Activity Relationship | 2006 |
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Topics: Animals; Brain; Cell Line; GABA Agonists; GABA-A Receptor Agonists; Humans; Imidazoles; In Vitro Techniques; Ligands; Membrane Potentials; Models, Molecular; Mutation; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Protein Subunits; Radioligand Assay; Rats; Receptors, GABA; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship | 2007 |
Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships.
Topics: Animals; Female; GABA Antagonists; Ligands; Models, Molecular; Molecular Structure; Oocytes; Structure-Activity Relationship; Xenopus laevis | 2008 |
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.
Topics: Computer Simulation; GABA-A Receptor Agonists; Magnetic Resonance Spectroscopy; Models, Molecular; Muscimol; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2013 |
Effects of GABA-mimetic agents on the cat spinal cord.
Topics: Animals; Bicuculline; Cats; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Ibotenic Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neurons, Afferent; Spinal Cord | 1979 |
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug | 1979 |
Does uptake limit the actions of GABA agonists in vivo? Experiments with muscimol, isoguvacine and THIP in cat spinal cord.
Topics: Aminobutyrates; Animals; Biological Transport; Cats; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons; Nipecotic Acids; Oxazoles; Spinal Cord | 1978 |
Muscimol and N,N-dimethylmuscimol: from a GABA agonist to a glycine antagonist.
Topics: Chemical Phenomena; Chemistry, Physical; Computer Simulation; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Structure-Activity Relationship | 1992 |
GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats.
Topics: Alcohol Drinking; Animals; Baclofen; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Rats; Receptors, GABA-A | 1992 |
Microstructural analysis of the effects of THIP, a GABAA agonist, on voluntary ethanol intake in laboratory rats.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Receptors, GABA-A | 1992 |
Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".
Topics: Aging; Aminobutyrates; Analgesics; Animals; Baclofen; Bicuculline; Binding, Competitive; Brain; Female; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Male; Muscimol; Receptors, GABA-A; Salmon; Sexual Behavior, Animal | 1992 |
Plasticity of the frog monocular OKN: involvement of pretectal GABAergic and cholinergic systems.
Topics: Animals; Atropine; gamma-Aminobutyric Acid; Isoxazoles; Microinjections; Nystagmus, Physiologic; Parasympathetic Nervous System; Rana esculenta; Vision, Monocular | 1992 |
Effect of a GABA agonist on the expression and distribution of GABAA receptors in the plasma membrane of cultured cerebellar granule cells: an immunocytochemical study.
Topics: Animals; Cell Membrane; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Rats; Receptors, GABA-A | 1991 |
Chronic flurazepam differentially regulates a behavioral effect of GABA agonists.
Topics: Animals; Drug Interactions; Flurazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Rotation; Substantia Nigra; Time Factors | 1991 |
Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Electrodes; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoxazoles; Nipecotic Acids; Potassium; Proline; Receptors, GABA-A; Temperature | 1991 |
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Motor Activity; Nerve Degeneration; Neurons; Nipecotic Acids; Rats; Rats, Inbred Strains; Synaptic Transmission; Tiagabine | 1991 |
GABAergic drugs and conflict behavior in the rat: lack of similarities with the actions of benzodiazepines.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Behavior, Animal; Benzodiazepines; Bicuculline; Brain; Conflict, Psychological; Drug Interactions; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1991 |
Why are most GABA agonists not effective antiepileptic drugs?
Topics: Animals; Anticonvulsants; Bicuculline; Cats; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Receptors, GABA-A; Synaptic Transmission; Trigeminal Nucleus, Spinal | 1991 |
GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat.
Topics: Analgesics; Anesthesia; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter | 1991 |
GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures.
Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Exploratory Behavior; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Social Behavior; Valproic Acid | 1991 |
Glycinergic control of [Leu5]enkephalin levels in chicken retina.
Topics: Animals; Baclofen; Chickens; Enkephalin, Leucine; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Muscimol; Neurotransmitter Agents; Picrotoxin; Radioimmunoassay; Retina; Strychnine | 1991 |
Activation of subconductance states by gamma-aminobutyric acid and its analogs in chick cerebral neurons.
Topics: Analgesics; Animals; Cells, Cultured; Cerebral Cortex; Chick Embryo; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Channels; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons | 1990 |
Stimulation of luteinizing hormone release by gamma-aminobutyric acid (GABA) agonists: mediation by GABAA-type receptors and activation of chloride and voltage-sensitive calcium channels.
Topics: Amino Acid Sequence; Animals; Baclofen; Calcium Channels; Cells, Cultured; Chloride Channels; Chlorides; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Isoxazoles; Luteinizing Hormone; Membrane Proteins; Molecular Sequence Data; Muscimol; Nifedipine; Pituitary Gland, Anterior; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells.
Topics: Animals; Anticonvulsants; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; Colchicine; Cycloheximide; Dactinomycin; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Monensin; Oxazoles; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Neurochemical correlates of gamma-aminobutyrate (GABA) inhibition in cat visual cortex.
Topics: Animals; Baclofen; Calcium; Cats; Cell Membrane; Female; GABA Antagonists; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Neurons; Potassium; Pyridazines; Receptors, GABA-A; Visual Cortex | 1990 |
Involvement of GABA receptors in the regulation of neurite growth in cultured embryonic chick tectum.
Topics: Animals; Axons; Baclofen; Cells, Cultured; Chick Embryo; Culture Media; gamma-Aminobutyric Acid; Isoxazoles; Ligands; Muscimol; Receptors, GABA-A; Superior Colliculi | 1990 |
GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat.
Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrodes; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Physical Stimulation; Somatosensory Cortex; Synapses | 1990 |
Abolition of monocular optokinetic nystagmus directional asymmetry after unilateral visual deprivation in adult vertebrates: involvement of the GABAergic mechanism.
Topics: Animals; Chickens; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Nystagmus, Physiologic; Rana esculenta; Sensory Deprivation; Visual Pathways | 1990 |
Binding of [3H]-muscimol to GABAA sites in the guinea-pig urinary bladder: biochemical assay and autoradiography.
Topics: Animals; Autoradiography; Bicuculline; Binding, Competitive; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Isoxazoles; Muscimol; Receptors, GABA-A; Tritium; Urinary Bladder | 1989 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
GABAergic drugs and lordosis behavior in the female rat.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Estradiol; Female; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Taurine | 1989 |
Stimulation by phaclofen of inositol 1,4,5-triphosphate production in cultured neurons from chick tectum.
Topics: Animals; Baclofen; Chick Embryo; gamma-Aminobutyric Acid; Inosine Nucleotides; Inosine Triphosphate; Isoxazoles; Neurons; Receptors, GABA-A; Superior Colliculi | 1989 |
Ionic mechanisms of action of GABA on dorsal and ventral root myelinated fibers: effects of K+ channel blockers.
Topics: 4-Aminopyridine; Animals; Barium; Barium Compounds; Cesium; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Neurons; Neurons, Afferent; Potassium; Potassium Channels; Rana catesbeiana; Tetraethylammonium Compounds | 1989 |
Late inhibitory postsynaptic potentials in rat prefrontal cortex may be mediated by GABAB receptors.
Topics: Animals; Baclofen; Electric Conductivity; Electric Stimulation; Evoked Potentials; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoxazoles; Male; Membrane Potentials; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Synapses | 1989 |
Role of GABAergic system in prolactin analgesia.
Topics: Analgesics; Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Prolactin | 1989 |
Effects of GABA, THIP, and potassium on excitability of myelinated axons of isolated amphibian spinal roots.
Topics: Anesthetics; Animals; Axons; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Myelin Sheath; Oxazoles; Potassium; Rana catesbeiana; Spinal Cord | 1989 |
Structural factors governing agonist and antagonist activity in the GABAA system.
Topics: Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Models, Molecular; Receptors, GABA-A; Structure-Activity Relationship | 1988 |
Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus.
Topics: Acetylcholine; Animals; Brain Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamus | 1988 |
GABA-related drugs modulate the behavioral effects of lorazepam.
Topics: Animals; Behavior, Animal; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Lorazepam; Male; Oxazoles; Receptors, GABA-A; Saimiri | 1988 |
Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors | 1987 |
Inhibition of sexual reflexes by lumbosacral injection of a GABAB agonist in the male rat.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Spinal; Isoxazoles; Lumbosacral Region; Male; Penile Erection; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Spinal Cord | 1988 |
The modulation of cortical acetylcholine release by GABA, GABA-like drugs and benzodiazepines in freely moving guinea-pigs.
Topics: Acetylcholine; Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Ethanolamines; Female; gamma-Aminobutyric Acid; Guinea Pigs; Isoxazoles; Male; Muscimol; Serotonin Antagonists | 1985 |
GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Antipsychotic Agents; Cebus; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Isoxazoles; Male; Vigabatrin | 1988 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1989 |
Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex.
Topics: Acetylcholine; Animals; Atropine; Baclofen; Benzodiazepinones; Clonazepam; Corpus Striatum; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Haloperidol; In Vitro Techniques; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine | 1985 |
Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Synergism; Electroshock; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Nervous System; Receptors, GABA-A | 1985 |
Parallel changes in the sensitivity of gamma-aminobutyric acid and noradrenergic receptors following chronic administration of antidepressant and GABAergic drugs. A possible role in affective disorders.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Baclofen; Cerebral Cortex; Dihydroalprenolol; gamma-Aminobutyric Acid; Hippocampus; Humans; Imipramine; Isoxazoles; Kinetics; Male; Mice; Mood Disorders; Nomifensine; Receptors, Adrenergic; Receptors, GABA-A | 1985 |
GABAergic drugs and sexual behaviour in the male rat.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1985 |
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, Neurologic; Muscimol; Muscle Relaxation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
GABAergic effects of reserpine following chronic treatment.
Topics: Animals; Baclofen; Binding, Competitive; Cerebral Cortex; Dihydroalprenolol; gamma-Aminobutyric Acid; Hippocampus; Imipramine; Isoxazoles; Male; Mice; Receptors, GABA-A; Reserpine | 1985 |
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Topics: Animals; Bicuculline; Brain; Cats; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Oxazolidinones; Piperidines; Rats; Receptors, GABA-A; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1985 |
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist.
Topics: Aggression; Animals; Bicuculline; Brain; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1985 |
GABAB receptor-mediated enhancement of vasoactive intestinal peptide-stimulated cyclic AMP production in slices of rat cerebral cortex.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Baclofen; Bicuculline; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasoactive Intestinal Peptide | 1986 |
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Nervous System; Oxazoles; Receptors, GABA-A; Seizures | 1986 |
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Receptors, GABA-A; Seizures | 1986 |
gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Baclofen; Bicuculline; Brain; Cell Membrane; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Liver; Male; Mice; Mice, Inbred DBA; Muscimol; Picrotoxin; Receptors, GABA-A; Sodium; Sulfates; Taurine; Temperature | 1986 |
Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.
Topics: Aggression; Aminocaproates; Animals; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Motor Activity; Muscimol; Nipecotic Acids; Olfactory Bulb; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission; Valproic Acid; Vigabatrin | 1986 |
The parafasciculus thalami as a site for mediating the antinociceptive response to GABAergic drugs.
Topics: Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Synaptic Transmission; Thalamic Nuclei | 1986 |
Effect of THIP and SL 76002, two clinically experimented GABA-mimetic compounds, on anterior pituitary GABA receptors and prolactin secretion in the rat.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Female; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Male; Muscimol; Ovariectomy; Oxazoles; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
GABAA receptors in the midbrain central grey mediate the antiaversive action of GABA.
Topics: Animals; Avoidance Learning; Baclofen; Electrodes, Implanted; gamma-Aminobutyric Acid; Isoxazoles; Male; Mesencephalon; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Effects of GABAergic drugs on the GABA turnover in the substantia nigra and the corpus striatum of the rat.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Corpus Striatum; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1987 |
[Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam].
Topics: Animals; Baclofen; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Pyrazoles; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Tranquilizing Agents | 1987 |
Cardiorespiratory effects produced by injecting drugs that affect GABA receptors into nuclei associated with the ventral surface of the medulla.
Topics: Animals; Bicuculline; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Female; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Muscimol; Respiration; Synaptic Transmission | 1987 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid | 1986 |
Inducing anesthesia with a GABA analog, THIP.
Topics: Analgesics; Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; gamma-Aminobutyric Acid; Isoxazoles; Ketamine; Male; Mice; Midazolam; Oxazoles; Rats; Rats, Inbred Strains; Sodium Oxybate; Time Factors | 1985 |
The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance.
Topics: Adolescent; Adult; Behavior; Carotid Arteries; Cerebrovascular Circulation; Dominance, Cerebral; Electroencephalography; gamma-Aminobutyric Acid; Humans; Injections, Intra-Arterial; Isoxazoles; Middle Aged; Neural Inhibition; Oxazoles; Synapses | 1988 |
Gamma-aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development.
Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasm; Endoplasmic Reticulum; gamma-Aminobutyric Acid; Golgi Apparatus; Isoxazoles; Microscopy, Electron; Oxazoles; Rats; Rats, Inbred Strains | 1988 |
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1988 |
GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Periaqueductal Gray; Picrotoxin; Raphe Nuclei; Rats; Rats, Inbred Strains | 1987 |
An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA).
Topics: Animals; Atropine; Atropine Derivatives; Baclofen; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Motor Activity; Pain; Pyrans; Pyrones | 1987 |
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam.
Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium | 1987 |
Effect of repeated treatment with a gamma-aminobutyric acid receptor agonist on postnatal neural development in rats.
Topics: Animals; Antigens, Surface; Brain; Cell Adhesion; Cell Adhesion Molecules; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Isoxazoles; Nerve Tissue Proteins; Neurons; Organ Size; Oxazoles; Rats; Rats, Inbred Strains | 1987 |
Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Histamine; Isoxazoles; Male; Methylhistamines; Methylhistidines; Mice; Muscimol | 1986 |
The effect of diazepam upon local cerebral glucose use in the conscious rat.
Topics: Animals; Autoradiography; Brain Chemistry; Deoxy Sugars; Deoxyglucose; Diazepam; Energy Metabolism; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains | 1986 |
GABA-mimetic drugs enhance apomorphine-induced contralateral turning in rats with unilateral nigrostriatal dopamine denervation: implications for the therapy of Parkinson's disease.
Topics: Alkynes; Aminocaproates; Animals; Antiparkinson Agents; Apomorphine; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Parkinson Disease; Rats; Rats, Inbred Strains | 1987 |
Subchronic administration of GABAergic agonists elevates [3H]GABA binding and produces tolerance in striatal dopamine catabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Baclofen; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Isoxazoles; Male; Pyrones; Rats; Rats, Inbred Strains; Vigabatrin | 1985 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Isoxazoles; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1985 |
GABAergic mechanisms in antinociception.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin | 1984 |
Somatic and dendritic actions of gamma-aminobutyric acid agonists and uptake blockers in the hippocampus in vivo.
Topics: Acetylcholine; Action Potentials; Animals; Dendrites; gamma-Aminobutyric Acid; Hippocampus; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Synaptic Transmission | 1984 |
GABAergic agents as anticonvulsants in baboons with photosensitive epilepsy.
Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Carbolines; Cerebral Cortex; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Papio; Photic Stimulation; Receptors, Cell Surface; Receptors, GABA-A; Taurine; Vigabatrin | 1984 |
Pretreatment with GABA and modulatory ligands enhances GABA receptor binding.
Topics: Animals; Baclofen; Binding Sites; Cerebral Cortex; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1984 |
Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones.
Topics: Animals; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Mice; Midazolam; Neurons; Oxazoles; Piperidines; Receptors, GABA-A | 1984 |
Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Time Factors | 1982 |
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid.
Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium | 1980 |
GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoxazoles; Muscimol; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Therapeutic failure of GABA agonist treatment in Huntington's disease.
Topics: gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoxazoles; Oxazoles | 1984 |
Multiple benzodiazepine receptor complexes: some benzodiazepine recognition sites are coupled to GABA receptors and ionophores.
Topics: Animals; Anions; Benzodiazepines; Bicuculline; Brain; Buffers; Flunitrazepam; gamma-Aminobutyric Acid; Haplorhini; Hot Temperature; Ionophores; Isonicotinic Acids; Isoxazoles; Macromolecular Substances; Papio; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1980 |
Role of GABA-ergic receptors for the synthesis of GABA in different compartments of the rat cerebellum.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
The binding of the GABA agonist [3H]THIP to rat brain synaptic membranes.
Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Tritium | 1982 |
THIP inhibits feeding behavior in fasted rats.
Topics: Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Eating; Food Deprivation; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Actions of GABAergic agents on dopamine metabolism in the nigrostriatal pathway of the rat.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Corpus Striatum; Diazepam; Dopamine; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Neural Pathways; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Substantia Nigra | 1982 |
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine.
Topics: Animals; Cats; gamma-Aminobutyric Acid; Glycine; Interneurons; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Structure-Activity Relationship | 1982 |
Autoreceptors modify the evoked release of [3H]GABA from cerebellar neurons in dissociated cell culture.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Fluspirilene; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Neurons; Potassium; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
GABAergic modulation of ethanol-induced motor impairment.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminobutyrates; Aminocaproates; Animals; Bicuculline; Brain; Ethanol; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Skills; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disease Susceptibility; Ethanol; Forelimb; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome; Tremor | 1983 |
GABA as a trophic factor during development.
Topics: Animals; Animals, Newborn; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Nipecotic Acids; Proline; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Retina | 1983 |
Diazepam stimulates the binding of GABA and muscimol but not THIP to rat brain membranes.
Topics: Analgesics; Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Comparison of GABA analogues at the crayfish stretch receptor neurone.
Topics: Animals; Astacoidea; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Isoxazoles; Mechanoreceptors; Membrane Potentials; Muscimol; Nipecotic Acids; Proline; Sodium | 1983 |
Diazotization and thiocyanate differentiate agonists from antagonists for the high- and low-affinity receptors of gamma-aminobutyric acid.
Topics: Androstanes; Animals; Azasteroids; Benzenesulfonates; Bicuculline; Cerebral Cortex; Diazonium Compounds; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids; Thiocyanates; Tubocurarine | 1984 |
Pharmacological analysis of the central cardiovascular effects of four GABA analogues.
Topics: Animals; Atropine; Bicuculline; Blood Pressure; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Isonicotinic Acids; Isoxazoles; Kainic Acid; Muscimol; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Microiontophoretically applied THIP effects upon nociceptive responses of neurons in medial thalamus.
Topics: Animals; Evoked Potentials; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Spinothalamic Tracts; Synaptic Transmission; Tail; Thalamic Nuclei | 1983 |
Effect of apomorphine and gabaergic drugs in monkeys pretreated with haloperidol.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Apomorphine; Chlorocebus aethiops; Female; gamma-Aminobutyric Acid; Haloperidol; Hemodynamics; Isoxazoles; Male; Motor Activity; Muscimol; Picrotoxin | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid | 1983 |
Methylphenidate, apomorphine, THIP, and diazepam in monkeys: dopamine-GABA behavior related to psychoses and tardive dyskinesia.
Topics: Animals; Apomorphine; Chlorocebus aethiops; Diazepam; Dopamine; Drug Interactions; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Isoxazoles; Male; Methylphenidate; Motor Activity; Oxazoles; Psychoses, Substance-Induced | 1984 |
Gabaergic modulation of mouse-killing in the rat.
Topics: Aggression; Aminocaproates; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Motor Activity; Nipecotic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Valproic Acid; Vigabatrin | 1984 |
Flight induced by infusion of bicuculline methiodide into periventricular structures.
Topics: Animals; Bicuculline; Brain Mapping; Escape Reaction; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus, Middle; Isoxazoles; Male; Motor Activity; Periaqueductal Gray; Rats; Rats, Inbred Strains | 1984 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Penicillins; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Taurine; Time Factors | 1984 |
Self-injurious behavior in rats produced by intranigral microinjection of GABA agonists.
Topics: Animals; Baclofen; Bicuculline; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Inbred Strains; Self Mutilation; Stress, Physiological; Substantia Nigra | 1984 |
The influence of GABAergic drugs on PGO activity in the cat.
Topics: Alkynes; Aminocaproates; Animals; Brain; Cats; Chlordiazepoxide; Electroencephalography; Female; gamma-Aminobutyric Acid; Geniculate Bodies; Isoxazoles; Male; Muscimol; Occipital Lobe; Pons | 1983 |
Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation.
Topics: Analgesics; Animals; Baclofen; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Motor Activity; Muscimol; Oxazoles; Physical Stimulation; Rats; Rats, Inbred Strains; Superior Colliculi; Touch | 1983 |
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist.
Topics: Aggression; Animals; Arousal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Injections, Intraventricular; Isoxazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time | 1983 |
Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neurons; Rabbits; Synapses | 1984 |
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; Mice; Mice, Inbred DBA; Myoclonus; Oxazoles; Papio; Photic Stimulation; Seizures; Time Factors | 1980 |
Nigral actions of GABA agonists are enhanced by chronic fluphenazine and differentiated by concomitant flurazepam.
Topics: Animals; Baclofen; Bicuculline; Female; Fluphenazine; Flurazepam; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1982 |
Quantitative determination of the gamma-aminobutyric acid agonist, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, in serum by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dogs; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Oxazoles; Papio; Rats; Spectrophotometry, Ultraviolet | 1983 |
Effects of the putative GABAergic agonists, muscimol and THIP, upon local cerebral glucose utilisation.
Topics: Analgesics; Animals; Brain; Deoxy Sugars; Deoxyglucose; gamma-Aminobutyric Acid; Glycolysis; Isoxazoles; Male; Muscimol; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains | 1982 |
Effects of GABA analogues and their interactions with morphine on locomotor activity in two inbred strains of mice.
Topics: Animals; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Muscimol; Piracetam | 1982 |
Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro.
Topics: Animals; Bicuculline; Dendrites; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Penicillins; Pentobarbital; Pyramidal Tracts; Rats; Receptors, Drug | 1982 |
Comparison of the antinociceptive actions of THIP and morphine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Reaction Time; Species Specificity | 1982 |
Antinociceptive and anticonvulsive effect of THIP, a pure GABA agonist.
Topics: Analgesics; Animals; Anticonvulsants; Benzoquinones; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time | 1982 |
Increases and decreases in local cerebral glucose utilization in response to GABA agonists.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glucose; Isoxazoles; Male; Muscimol; Oxazoles; Rats | 1981 |
GABA in the entopeduncular nucleus and the subthalamic nucleus participates in mediating dopaminergic striatal output functions.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Mesencephalon; Muscimol; Neural Pathways; Picrotoxin; Rats; Rats, Inbred Strains; Thalamic Nuclei | 1981 |
Etomidate stereospecifically stimulates forebrain, but not cerebellar, 3H-diazepam binding.
Topics: Animals; Brain; Cerebellum; Diazepam; Etomidate; Female; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereoisomerism; Synaptic Membranes | 1981 |
Paradoxical blockade of a muscimol response by THIP, a GABA agonist and also by GABA-transaminase inhibitors.
Topics: 4-Aminobutyrate Transaminase; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Myoclonus; Oxazoles; Time Factors; Transaminases | 1981 |
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Motor Activity; Muscimol; Pain; Phencyclidine; Reflex | 1980 |
GABAergic actions of THIP in vivo and vitro: a comparison with muscimol and GABA.
Topics: Animals; Binding Sites; Brain; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Oxazoles; Rats; Substantia Nigra | 1980 |
Intravenous GABA agonist administration stimulates firing of A10 dopaminergic neurons.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Injections, Intravenous; Isoxazoles; Limbic System; Muscimol; Neurons; Rats | 1980 |
Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Benzodiazepines; Binding Sites; Binding, Competitive; Blotting, Western; Cattle; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Macromolecular Substances; Molecular Sequence Data; Muscimol; Precipitin Tests; Rabbits; Rats; Receptors, GABA-A; Sensitivity and Specificity; Sequence Homology, Amino Acid; Tritium | 1995 |
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1995 |
Extrasynaptic effects of GABA (gamma-aminobutyric acid) agonists on myelinated axons of peripheral nerve.
Topics: Action Potentials; Animals; Axons; Baclofen; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Nerve Fibers, Myelinated; Peripheral Nerves; Rana catesbeiana; Ranidae; Sciatic Nerve; Spinal Nerve Roots; Synapses | 1994 |
Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.
Topics: Animals; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Oocytes; Oxazolidinones; Piperidines; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1994 |
Stimulation or blockade of the dorsal nucleus of the lateral lemniscus alters binaural and tonic inhibition in contralateral inferior colliculus neurons.
Topics: Acoustic Stimulation; Animals; Auditory Pathways; Electric Stimulation; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Lidocaine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA; Spiral Ganglion | 1993 |
GABA alters GABAA receptor mRNAs and increases ligand binding.
Topics: Animals; Anticonvulsants; Base Sequence; Bicuculline; Cells, Cultured; Cerebellum; DNA Primers; gamma-Aminobutyric Acid; Gene Expression; Isoxazoles; Macromolecular Substances; Molecular Sequence Data; Muscimol; Neurons; Polymerase Chain Reaction; Rats; Receptors, GABA-A; RNA, Messenger | 1993 |
gamma-Aminobutyric acid-A (GABAA) agonists down-regulate GABAA/benzodiazepine receptor polypeptides from the surface of chick cortical neurons.
Topics: Androstanes; Animals; Azasteroids; Blotting, Western; Cells, Cultured; Cerebral Cortex; Chick Embryo; Down-Regulation; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Molecular Weight; Neurons; Receptors, GABA-A | 1994 |
GABA, THIP and baclofen inhibition of Purkinje cells and cerebellar nuclei neurons.
Topics: Animals; Baclofen; Cerebellar Nuclei; Dose-Response Relationship, Drug; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Neural Inhibition; Neurons; Purkinje Cells; Rats; Rats, Sprague-Dawley | 1993 |
A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin.
Topics: Analgesics; Animals; Flavonoids; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Pain Measurement; Parasympathetic Nervous System; Parasympathomimetics | 1993 |
Reduced function of gamma-aminobutyric acidA receptors in tottering mouse brain: role of cAMP-dependent protein kinase.
Topics: Animals; Brain Chemistry; Chloride Channels; Chlorine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GABA Agonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isoquinolines; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Protein Kinase Inhibitors; Radioisotopes; Receptors, GABA-A; Sulfonamides | 1995 |
Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nuclei.
Topics: Animals; Cerebellum; Enzyme Inhibitors; Evoked Potentials; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Long-Term Potentiation; Male; Marine Toxins; Microcystins; Neurons; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor.
Topics: Acrylates; Animals; Drosophila melanogaster; Female; GABA Agonists; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Isoxazoles; Oocytes; Receptors, GABA; Recombinant Proteins; Xenopus | 1996 |
N-ethylmaleimide blocks depolarization-induced suppression of inhibition and enhances GABA release in the rat hippocampal slice in vitro.
Topics: Analysis of Variance; Animals; Baclofen; Ethylmaleimide; Evoked Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA | 1997 |
Neuronal regulation of astrocyte morphology in vitro is mediated by GABAergic signaling.
Topics: Animals; Animals, Newborn; Astrocytes; Baclofen; Bicuculline; Cell Adhesion; Cells, Cultured; Coculture Techniques; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Isoxazoles; Muscimol; Neurons; Rats; Rats, Wistar; Signal Transduction; Sodium Channel Blockers; Tetrodotoxin; Time Factors | 1997 |
Neurosteroid inhibition of cell death.
Topics: Alkaloids; Animals; Antimycin A; Benzylisoquinolines; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Dehydroepiandrosterone Sulfate; Female; gamma-Aminobutyric Acid; Isoxazoles; Kidney Tubules, Proximal; Kinetics; L-Lactate Dehydrogenase; Mitochondria; Muscimol; Oxygen Consumption; Pregnanes; Rabbits; Receptors, GABA-A | 1997 |
The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine.
Topics: Amphetamine; Animals; Bicuculline; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Frontal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Models, Neurological; Motor Activity; Stereotyped Behavior; Sulpiride | 1998 |
Defining affinity with the GABAA receptor.
Topics: Animals; Animals, Newborn; beta-Alanine; Cells, Cultured; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Ligands; Muscimol; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Receptors, GABA-A | 1998 |
Channel properties determine the transient activation kinetics of recombinant GABA(A) receptors.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Membrane Potentials; Protein Isoforms; Receptors, GABA-A; Recombinant Fusion Proteins; Time Factors | 1999 |
Opposite roles of GABA and excitatory amino acids on the control of GAD expression in cultured retina cells.
Topics: Animals; Baclofen; Cells, Cultured; Chick Embryo; Cytarabine; Excitatory Amino Acid Agonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoxazoles; Kainic Acid; Nitric Oxide; Retina | 2002 |
GABAergic and glutamatergic terminals differentially influence the organization of GABAergic synapses in rat cerebellar granule cells in vitro.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cerebellar Cortex; Fluorescent Antibody Technique; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Presynaptic Terminals; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes; Synaptic Transmission; Vesicular Glutamate Transport Protein 1; Vesicular Transport Proteins | 2002 |
Gamma-aminobutyric acid-induced calcium signalling in rat superior collicular neurones.
Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Cytarabine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Neurons; Phosphinic Acids; Pyridines; Rats; Receptors, GABA; Superior Colliculi | 2002 |
Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.
Topics: Animals; Chloride Channels; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Membrane Potentials; Neural Inhibition; Organ Culture Techniques; Pyramidal Cells; Rats; Reaction Time; Receptors, GABA-A; Synaptic Transmission | 2003 |
Evidence for inhibitory effect of the agonist gaboxadol at human alpha 1 beta 2 gamma 2S GABAA receptors.
Topics: Animals; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Membrane Potentials; Neural Inhibition; Protein Subunits; Rats; Receptors, GABA-A | 2003 |
Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits.
Topics: Animals; Binding Sites; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Deletion; Isoxazoles; Mice; Protein Subunits; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, GABA-A; Reflex; Tritium | 2004 |
Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.
Topics: Amino Acid Sequence; Amino Acids, Cyclic; Binding Sites; Carboxylic Acids; Cations; Crotonates; Cyclopropanes; Dose-Response Relationship, Drug; Electric Conductivity; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Imidazoles; Ion Channel Gating; Isoxazoles; Molecular Sequence Data; Molecular Structure; Muscimol; Mutagenesis, Site-Directed; Proline; Protein Subunits; Receptors, GABA; Static Electricity; Structure-Activity Relationship | 2004 |
Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Isoxazoles; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors; Triazolam; Women | 2005 |
Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2.
Topics: Animals; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lanthanum; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis; Zinc | 2006 |
Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Morphine; Muscimol; Narcotics; Neurons; Nociceptors; Pain Measurement; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time | 2006 |
A single point mutation of the GABA(A) receptor alpha5-subunit confers fluoxetine sensitivity.
Topics: Amino Acid Substitution; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fluoxetine; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Membrane Potentials; Models, Molecular; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Xenopus laevis | 2007 |
Auto-modulation of neuroactive steroids on GABA A receptors: a novel pharmacological effect.
Topics: Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Membrane Potentials; Patch-Clamp Techniques; Pregnanediones; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Steroids | 2007 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Isoxazoles; Male; Morphine; Neuralgia; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Pharmacogenetics; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Reproducibility of Results; Species Specificity | 2007 |
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.
Topics: Animals; Bicuculline; Electrophysiology; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Medulla Oblongata; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Synapses | 2007 |
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Subcellular Fractions | 2007 |
GABAergic modulation of binge-like ethanol intake in C57BL/6J mice.
Topics: Alcoholism; Animals; Baclofen; Central Nervous System Depressants; Darkness; Dose-Response Relationship, Drug; Ethanol; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Postural Balance | 2007 |
Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors.
Topics: Animals; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dark Adaptation; Dose-Response Relationship, Drug; Exploratory Behavior; Female; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Isoxazoles; Male; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Binding; Protein Subunits; Reaction Time; Receptors, GABA-A; Reflex; Thy-1 Antigens; Transfection | 2008 |
Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors.
Topics: Animals; Cell Line; Computer Simulation; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Isoxazoles; Kinetics; Membrane Potentials; Mice; Models, Chemical; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Fusion Proteins; Transfection | 2008 |
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Azabicyclo Compounds; Baclofen; Benzodiazepines; Bicuculline; Brain; Cyclohexanecarboxylic Acids; Discrimination Learning; Dose-Response Relationship, Drug; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Generalization, Stimulus; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoxazoles; Male; Nipecotic Acids; Piperazines; Pyridines; Rats; Thiophenes; Tiagabine; Zolpidem | 2008 |
Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex.
Topics: Anesthetics; Animals; Animals, Newborn; Desoxycorticosterone; Drug Interactions; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Neocortex; Neural Inhibition; Neurons; Patch-Clamp Techniques; Reaction Time; Receptors, GABA-A | 2008 |
Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks.
Topics: Animals; Cerebral Cortex; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Homeostasis; Isoxazoles; Long-Term Potentiation; Models, Neurological; Neural Inhibition; Neuronal Plasticity; Organ Culture Techniques; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 2008 |
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.
Topics: Animals; Binding Sites; Brain; Cell Line; Electrophysiology; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Subunits; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning.
Topics: Anesthetics; Animals; Behavior, Animal; Brain; Conditioning, Classical; Electroshock; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Learning; Motor Activity; Neural Inhibition; Photic Stimulation; Rabbits; Receptors, GABA-B | 2009 |
The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA receptors.
Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Neural Inhibition; Neurons; Neurotransmitter Agents; Raphe Nuclei; Rats; Receptors, GABA-A; Serotonin | 2010 |
Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity.
Topics: Animals; Anti-Anxiety Agents; Biophysical Phenomena; Central Nervous System Depressants; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethanol; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Transfection; Xenopus | 2009 |
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.
Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Male; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2011 |
Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Fibroblasts; GABA Agonists; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentration; Isoxazoles; Kidney; Mice; Muscimol; Patch-Clamp Techniques; Receptors, GABA-A; Synapses; Transfection | 2010 |
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
Topics: Amygdala; Animals; Disease Models, Animal; Evoked Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Interneurons; Isoxazoles; Male; Mice; Mice, Knockout; Neural Inhibition; Neurons; Patch-Clamp Techniques; Synaptic Transmission | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex | 2011 |
Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex.
Topics: Animals; Association Learning; Electrophysiological Phenomena; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Interneurons; Isoxazoles; Male; Mice; Neural Conduction; Neurons; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Sex Characteristics; Somatosensory Cortex | 2011 |
Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice.
Topics: Action Potentials; Analgesics; Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Formaldehyde; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hindlimb Suspension; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Pain Measurement; Psychomotor Performance; Receptors, GABA-A; Sensory Receptor Cells; Spinal Cord | 2011 |
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Mice; Mice, Knockout; Motor Activity; Neuropsychological Tests; Receptors, GABA-A | 2011 |
Intracellular chloride concentration influences the GABAA receptor subunit composition.
Topics: Animals; Bumetanide; Carboxylic Acids; Cells, Cultured; Cerebellum; Chlorides; gamma-Aminobutyric Acid; Indenes; Isoxazoles; K Cl- Cotransporters; Mice; Neurons; Patch-Clamp Techniques; Protein Subunits; Pyridines; Receptors, GABA-A; RNA Interference; RNA, Small Interfering; Symporters; Zolpidem | 2012 |
Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.
Topics: Animals; Benzodiazepines; Binding Sites; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Isoxazoles; Larva; Membrane Potentials; Models, Biological; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Protein Subunits; Receptors, GABA-A; Xenopus | 2012 |
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
Topics: Angelman Syndrome; Animals; Cerebellum; Disease Models, Animal; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoxazoles; Mice; Purkinje Cells; Ubiquitin-Protein Ligases | 2012 |
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Synapses; Synaptic Transmission | 2013 |
A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.
Topics: Action Potentials; Animals; Cerebellum; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glutamates; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Mice, Inbred C57BL; Neural Inhibition; Neurons; Protein Subunits; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate; Synapses; Synaptic Transmission | 2013 |
Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?
Topics: Animals; Chlorides; GABA-A Receptor Agonists; GABAergic Neurons; gamma-Aminobutyric Acid; Geniculate Bodies; Inferior Colliculi; Isoxazoles; Male; Rats; Rats, Inbred F344; Rats, Long-Evans; Receptors, GABA-A; Synapses; Synaptic Potentials | 2014 |
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation | 2014 |
Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3.
Topics: Animals; Anisoles; Astrocytes; Corpus Striatum; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Huntington Disease; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Transgenic; Neural Inhibition; Neurons; Nipecotic Acids; Patch-Clamp Techniques; Synaptic Transmission | 2013 |
GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo.
Topics: Action Potentials; Animals; Biophysics; Calcium; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Functional Laterality; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Mice; Oxygen Consumption; Partial Pressure; Pyridines; Receptors, GABA-A; Somatosensory Cortex; Sulfonamides; Thiazoles; Vibrissae; Zolpidem | 2015 |
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neurons; Seizures; Synapsins | 2015 |
Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma.
Topics: Anesthetics, General; Cell Line, Tumor; Diazepam; Drug Synergism; Electrophysiological Phenomena; Etomidate; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Ion Channel Gating; Isoxazoles; Propofol; Protein Subunits; Protein Transport; Receptors, GABA-A | 2015 |
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization.
Topics: Botulinum Toxins, Type A; Cell Membrane; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Dynamins; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrazones; Immunohistochemistry; Isoxazoles; Leupeptins; Membrane Potentials; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Transfection | 2016 |
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.
Topics: Aminolevulinic Acid; Animals; beta-Alanine; Caco-2 Cells; Cell Line; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kidney; LLC-PK1 Cells; Membrane Glycoproteins; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Osmolar Concentration; Osmosis; Proline; Rats; RNA, Messenger; Swine; Taurine; Vigabatrin | 2016 |
A pharmacological characterization of GABA, THIP and DS2 at binary α4β3 and β3δ receptors: GABA activates β3δ receptors via the β3(+)δ(-) interface.
Topics: Animals; Benzamides; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Subunits; Receptors, GABA-A; Xenopus laevis | 2016 |
Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.
Topics: Animals; Chronic Pain; Extracellular Space; Freund's Adjuvant; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Knockout Techniques; Hyperalgesia; Inflammation; Isoxazoles; Male; Muscimol; Optogenetics; Patch-Clamp Techniques; Protein Subunits; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission; Thalamus | 2017 |
Interaction between central GABAA receptor and dopaminergic system on food intake in neonatal chicks: role of D
Topics: Adrenergic Agents; Analysis of Variance; Animals; Animals, Newborn; Benzazepines; Chickens; Dopamine; Dopamine Agents; Eating; Female; Food Deprivation; GABA Agents; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Levodopa; Oxidopamine; Receptors, Dopamine D1; Receptors, GABA-A | 2018 |