gabexate has been researched along with nafamostat in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (9.68) | 18.7374 |
| 1990's | 22 (35.48) | 18.2507 |
| 2000's | 11 (17.74) | 29.6817 |
| 2010's | 13 (20.97) | 24.3611 |
| 2020's | 10 (16.13) | 2.80 |
| Authors | Studies |
|---|---|
| Birchall, K; Chapman, TM; Desai, B; Klefström, J; Mukonoweshuro, A; Pant, SM; Ramjee, MK; Selway, CN; Tarver, GJ; Tervonen, TA; Wright, AG | 1 |
| Pilgram, O; Steinmetzer, T; Wenzel, BM; Wiedemeyer, SJA | 1 |
| Bouckaert, C; Davoine, C; Fillet, M; Pochet, L | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Kashima, K; Kataoka, K; Umehara, K | 1 |
| Akizawa, T; Kinugasa, E; Koshikawa, S; Makita, T | 1 |
| Terada, H | 1 |
| Harada, M; Murakawa, M; Niho, Y; Okamura, T; Otsuka, T; Shibuya, T | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Ren, LM; Yonekura, H | 1 |
| Takeuchi, T; Toki, F; Yoshida, K | 1 |
| Babicki, A; Basiński, A; Dobosz, M; Juszkiewicz, P; Sledziński, Z; Wajda, Z | 1 |
| Komi, N; Matsumura, T; Miyoshi, Y; Yada, S | 1 |
| Imamura, M; Teshima, S; Yamauchi, H | 1 |
| Matsuda, O | 1 |
| Kano, M; Shimoyama, T; Shintani, S; Wada, M; Yamashita, M | 1 |
| Kawaguchi, Y; Sakai, O; Yamamoto, H | 1 |
| Hori, R; Ishida, T; Iwakawa, S; Kokubu, N; Komada, F; Okumura, K; Takeyama, M | 1 |
| Ohsato, K; Okamoto, K; Takeda, S | 1 |
| Fuwa, T; Hirai, M; Iwakawa, S; Kiyohara, Y; Komada, F; Okumura, K | 1 |
| Ino, Y; Iwaki, M; Sato, T; Suzuki, K | 1 |
| Asou, T; Fukamachi, K; Kinoshita, K; Komori, M; Masuda, M; Matsuzaki, K; Mayumi, H; Miyamoto, K; Tominaga, R; Toshima, Y | 1 |
| Futagami, M; Imaki, K; Kawasaki, A; Matsuoka, S; Ohno, H; Okegawa, T | 1 |
| Kohama, A; Nakamura, Y; Shibata, S; Takemoto, Y; Tanabe, J; Tanaka, S | 1 |
| Fuchinoue, S; Honda, H; Kawai, T; Sanaka, T; Takahashi, K; Tanabe, K; Teraoka, S; Toma, H; Yagisawa, T; Yamaguchi, Y | 1 |
| Miyazaki, M; Ogli, K; Yoda, K; Yokono, S | 1 |
| Dabrowski, A; Gabryelewicz, A | 1 |
| Kikuchi, H; Okamoto, S; Yanamoto, H | 1 |
| Fujimoto, M; Hirano, K; Inui, K; Kanemaki, N; Nakazawa, S; Okushima, K; Wakabayashi, T; Yamachika, H; Yamao, K; Yoshino, J | 1 |
| De Clercq, E; Hosoya, M; Ishii, T; Shigeta, S; Suzuki, H | 1 |
| Fuwa, T; Iwakawa, S; Kiyohara, Y; Komada, F; Okumura, K | 1 |
| Aramoto, H; Muto, T; Saito, H; Shigematsu, H | 1 |
| Kinoshita, H; Shibata, T; Suehiro, S; Yamamoto, F | 1 |
| Antoniu, BA; Balcom, JH; Fernández-del Castillo, CF; Keck, T; Lewandrowski, K; Warshaw, AL | 1 |
| Fujita, H; Ishigatsubo, Y; Kanamori, H; Kihara, M; Maruta, A; Naitoh, A; Nakamura, S; Nozue, N; Ota, Y; Tomita, N | 1 |
| Horie, O; Kitamura, N; Koshiba, M; Kumagai, S; Ryo, R; Saigo, K; Yamamoto, M | 1 |
| Hitosugi, M; Kurosu, A; Nagai, T; Nihei, H; Niwa, M; Takahashi, T; Tokudome, S | 1 |
| Aki, K; Goromaru, T; Ito, Y; Itoh, Y; Mori, S; Nishibori, M; Oike, M; Oishi, R; Sendo, T; Sumimura, T; Yano, T | 1 |
| Itoh, Y; Mori, S; Nishibori, M; Oishi, R; Sendo, T; Shinohata, R | 1 |
| Ikeda, M; Kaizu, K; Uriu, K | 1 |
| Kohsaki, T; Nishimori, I; Onishi, S | 1 |
| Noda, Y; Yin, J; Yotsuyanagi, T | 1 |
| Chen, CL; Kao, ST; Lin, KJ; Tani, T; Wang, JY; Wang, SD; Yu, CK; Zeng, ZY | 1 |
| Aki, T; Egashira, N; Hama, M; Itoh, Y; Oishi, R; Yamauchi, Y; Yano, T | 1 |
| Koyama, T | 1 |
| Hide, M; Kameyoshi, Y; Shindo, H; Takahagi, S; Watanabe, M | 1 |
| Takahashi, H | 1 |
| Cho, CM; Jang, SY; Jeon, SW; Jung, MK; Kim, JY; Kim, SK; Kweon, YO; Kwon, YH; Lee, SJ; Park, HW; Tak, WY; Yang, HM | 1 |
| Fujimoto, S; Fujita, H; Hazama, Y; Kuhara, K; Moriyama, A; Nishimura, S; Ohtake, C; Sakuma, R | 1 |
| Chujo, D; Fujita, Y; Itoh, T; Iwanaga, Y; Jackson, A; Kamiya, H; Kobayashi, N; Levy, MF; Liu, X; Matsumoto, S; Nagata, H; Naziruddin, B; Noguchi, H; Okitsu, T; Onaca, N; Peng, H; Shimoda, M; Sugimoto, K; Takita, M; Ueda, M | 1 |
| Matsumoto, T; Wada, H; Yamashita, Y | 1 |
| Chao, YP; Chiang, CJ; Kao, ST; Lin, CC; Lin, J; Lin, LJ; Wang, SD | 1 |
| Ammendola, M; De Sarro, G; Gadaleta, CD; Leporini, C; Marech, I; Oakley, C; Ranieri, G; Russo, E; Sacco, R; Sammarco, G | 1 |
| Sakamoto, Y; Yahata, M | 1 |
| Hirono, S; Masuda, Y; Yamaotsu, N | 1 |
| Ashizawa, M; Fujiwara, SI; Hatano, K; Ikeda, T; Ito, S; Kanda, Y; Kawaguchi, SI; Kawasaki, Y; Mashima, K; Minakata, D; Morita, K; Muroi, K; Nagayama, T; Nakano, H; Ochi, SI; Oh, I; Ohmine, K; Ohmori, T; Sato, K; Sugimoto, M; Toda, Y; Umino, K; Yamamoto, C; Yamasaki, R | 1 |
| Fang, Y; Meng, XM; Ni, WJ; Shen, AZ; Xu, T; Zhou, H | 1 |
| Deng, X; Kikuchi, A; Nagatomi, R; Nishimura, H; Yamaya, M | 1 |
| Gohda, J; Imai, M; Inoue, JI; Iwatsuki-Horimoto, K; Kawaguchi, Y; Kawaoka, Y; Kinoshita, N; Kiso, M; Matsuda, Z; Ohmagari, N; Sakai-Tagawa, Y; Semba, K; Takeda, M; Yamamoto, M | 1 |
| Al-Rejaie, S; ElMasry, G; Kishk, RM; Kishk, SM; Nafie, MS; Nemr, NA; Simons, C; Yassen, ASA | 1 |
| Barygin, OI; Zhigulin, AS | 1 |
| Barygin, OI; Tikhonov, DB; Zhigulin, AS | 1 |
| C, AM; Ponnuraj, K; Wessler, S | 1 |
10 review(s) available for gabexate and nafamostat
| Article | Year |
|---|---|
Factor XII/XIIa inhibitors: Their discovery, development, and potential indications.
Topics: Animals; Anticoagulants; Drug Discovery; Factor XII; Factor XIIa; Humans; Serine Proteinase Inhibitors | 2020 |
[Synthetic protease inhibitors in the treatment of disseminated intravascular coagulation].
Topics: Benzamidines; Disseminated Intravascular Coagulation; Gabexate; Glycoproteins; Guanidines; Half-Life; Humans; Male; Middle Aged; Proteins | 1993 |
[Changes in coagulation, fibrinolysis and platelet functions during extracorporeal circulation].
Topics: Anticoagulants; Benzamidines; Blood Coagulation; Dose-Response Relationship, Drug; Extracorporeal Circulation; Fibrinolysis; Gabexate; Guanidines; Heparin; Heparin, Low-Molecular-Weight; Humans; Platelet Activation; Renal Dialysis | 2004 |
[Treatment of acute pancreatitis with protease inhibitor, H2 receptor antagonist and somatostatin analogue].
Topics: Acute Disease; Aprotinin; Benzamidines; Cimetidine; Drug Administration Schedule; Drug Therapy, Combination; Gabexate; Glycoproteins; Guanidines; Histamine H2 Antagonists; Humans; Octreotide; Pancreatitis; Protease Inhibitors; Randomized Controlled Trials as Topic; Severity of Illness Index; Somatostatin | 2004 |
[Treatment of disseminated intravascular coagulation].
Topics: Anticoagulants; Antithrombins; Benzamidines; Chondroitin Sulfates; Dalteparin; Dermatan Sulfate; Disseminated Intravascular Coagulation; Gabexate; Guanidines; Heparin; Heparitin Sulfate; Humans; Protease Inhibitors; Protein C; Recombinant Proteins; Thrombomodulin; Tretinoin | 2010 |
[Synthetic protease inhibitors for the treatment of DIC].
Topics: Anticoagulants; Arginine; Benzamidines; Disseminated Intravascular Coagulation; Gabexate; Guanidines; Humans; Pipecolic Acids; Protease Inhibitors; Sulfonamides | 2011 |
[Recent therapeutic strategy for disseminated intravascular coagulation].
Topics: Anticoagulants; Antifibrinolytic Agents; Antithrombins; Benzamidines; Disseminated Intravascular Coagulation; Fibrinogen; Gabexate; Guanidines; Heparin; Humans; Molecular Targeted Therapy; Plasma; Platelet Transfusion; Practice Guidelines as Topic; Serine Proteinase Inhibitors; Thrombomodulin | 2014 |
Targeting mast cells in gastric cancer with special reference to bone metastases.
Topics: Animals; Antigens, CD34; Benzamides; Benzamidines; Bone and Bones; Bone Neoplasms; Bone Resorption; Disease Progression; Gabexate; Guanidines; Humans; Imatinib Mesylate; Immune System; Mast Cells; Neovascularization, Pathologic; NF-kappa B; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Stomach Neoplasms; Thiazoles; Tryptases | 2015 |
[Anti DIC therapy].
Topics: Anticoagulants; Antifibrinolytic Agents; Antithrombins; Benzamidines; Disseminated Intravascular Coagulation; Gabexate; Guanidines; Heparin; Humans; Protease Inhibitors; Recombinant Proteins; Sepsis; Systemic Inflammatory Response Syndrome; Thrombomodulin; Tranexamic Acid; Wounds and Injuries | 2016 |
Potential therapeutic targets and promising drugs for combating SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Basigin; Benzamidines; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Cytokine Release Syndrome; Esters; Gabexate; Genome, Viral; Guanidines; Humans; Immunization, Passive; Immunosuppressive Agents; Medicine, Chinese Traditional; Nucleic Acid Synthesis Inhibitors; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Protease Inhibitors; RNA-Dependent RNA Polymerase; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Viral Vaccines; Virus Internalization; Virus Replication | 2020 |
1 trial(s) available for gabexate and nafamostat
| Article | Year |
|---|---|
[Could nafamostat or gabexate prevent the post endoscopic retrograde cholangiopancreatography pancreatitis?].
Topics: Adult; Aged; Aged, 80 and over; Benzamidines; Cholangiopancreatography, Endoscopic Retrograde; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Pancreatitis; Placebo Effect; Serine Proteinase Inhibitors; Surveys and Questionnaires; Young Adult | 2012 |
51 other study(ies) available for gabexate and nafamostat
| Article | Year |
|---|---|
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.
Topics: Breast Neoplasms; Cell Proliferation; Drug Design; Enzyme Inhibitors; Female; High-Throughput Screening Assays; Humans; Models, Molecular; Molecular Structure; Protein Conformation; Serine Endopeptidases; Tumor Cells, Cultured | 2018 |
Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.
Topics: Animals; Antifibrinolytic Agents; Catalytic Domain; Crystallography, X-Ray; Fibrinolysin; Fibrinolysis; Hemorrhage; Humans; Ligands; Molecular Structure; Plasminogen; Protein Binding; Protein Domains | 2020 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
[Treatment of acute pancreatitis].
Topics: Acute Disease; Benzamidines; Disseminated Intravascular Coagulation; Drainage; Gabexate; Glycoproteins; Guanidines; Humans; Multiple Organ Failure; Pancreatitis; Plasma Exchange; Shock; Tomography, X-Ray Computed | 1992 |
[Treatment of uremic patients at high bleeding risk].
Topics: Benzamidines; Blood Transfusion; Deamino Arginine Vasopressin; Gabexate; Guanidines; Hemorrhage; Heparin; Humans; Kidney Failure, Chronic; Molecular Weight; Protease Inhibitors; Renal Dialysis; Uremia | 1992 |
[Changes in platelets, coagulation and fibrinolysis in patients with chronic kidney diseases and hemodialysis].
Topics: Benzamidines; Blood Coagulation; Blood Platelets; Epoprostenol; Fibrinolysis; Gabexate; Guanidines; Heparin; Humans; Kidney Failure, Chronic; Nephrotic Syndrome; Platelet Count; Renal Dialysis | 1992 |
Use of a synthetic protease inhibitor for the treatment of L-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamidines; Cyclophosphamide; Disseminated Intravascular Coagulation; Female; Gabexate; Guanidines; Humans; Male; Methotrexate; Pancreatitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protease Inhibitors; Vincristine | 1992 |
Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aprotinin; Benzamidines; Bicarbonates; Body Water; Cyclic AMP; Dogs; Esters; Female; Gabexate; Glycoproteins; Guanidines; In Vitro Techniques; Male; Pancreas; Perfusion; Protease Inhibitors; Secretin | 1990 |
[Antienzyme preparations in the treatment of acute pancreatitis].
Topics: Acute Disease; Adult; Aprotinin; Benzamidines; Cytidine Diphosphate Choline; Disseminated Intravascular Coagulation; Esters; Gabexate; Glycoproteins; Guanidines; Humans; Male; Multiple Organ Failure; Pancreatitis; Serine Proteinase Inhibitors; Trypsin Inhibitors | 1990 |
Synthetic antiproteases in acute pancreatitis: an experimental study.
Topics: Acute Disease; Animals; Benzamidines; Dogs; Gabexate; Guanidines; Hemodynamics; Hemorrhage; Pancreatitis; Protease Inhibitors | 1992 |
[Effect of synthetic protease inhibitor on the sphincter of Oddi function in dogs].
Topics: Animals; Benzamidines; Dogs; Gabexate; Guanidines; Movement; Protease Inhibitors; Sphincter of Oddi | 1991 |
[Effects of protease inhibitors on the motor activity of canine sphincter of Oddi].
Topics: Animals; Benzamidines; Dogs; Gabexate; Guanidines; Movement; Protease Inhibitors; Sphincter of Oddi | 1991 |
[Anticoagulation].
Topics: Benzamidines; Blood Coagulation; Citrates; Citric Acid; Gabexate; Guanidines; Heparin; Humans; Molecular Weight; Renal Dialysis | 1991 |
[Anticoagulant in plasmapheresis].
Topics: Anticoagulants; Benzamidines; Biocompatible Materials; Citrates; Citric Acid; Gabexate; Guanidines; Heparin; Humans; Membranes, Artificial; Plasmapheresis | 1991 |
[Protease inhibitors as anticoagulant in hemodialysis].
Topics: Benzamidines; Blood Coagulation Disorders; Gabexate; Guanidines; Humans; Protease Inhibitors; Renal Dialysis | 1991 |
Enhanced bioavailability of subcutaneously injected insulin by pretreatment with ointment containing protease inhibitors.
Topics: Administration, Topical; Adult; Animals; Benzamidines; Biological Availability; Gabexate; Guanidines; Heart Arrest, Induced; Humans; Injections, Subcutaneous; Insulin; Iodine Radioisotopes; Male; Mice; Mice, Hairless; Ointments; Protease Inhibitors; Rats; Rats, Inbred Strains | 1991 |
[Treatment of disseminated intravascular coagulation with proteinase inhibitor].
Topics: Antithrombin III; Benzamidines; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Gabexate; Glycoproteins; Guanidines; Heparin; Humans; Middle Aged; Protease Inhibitors; Protein C | 1991 |
Improvement in wound healing by epidermal growth factor (EGF) ointment. I. Effect of nafamostat, gabexate, or gelatin on stabilization and efficacy of EGF.
Topics: Animals; Benzamidines; Biotransformation; Dose-Response Relationship, Drug; Drug Combinations; Drug Stability; Epidermal Growth Factor; Gabexate; Gelatin; Guanidines; Male; Ointments; Protease Inhibitors; Rats; Rats, Inbred Strains; Wound Healing; Wounds and Injuries | 1990 |
[Comparative studies of nafamostat mesilate and various serine protease inhibitors in vitro].
Topics: alpha-Macroglobulins; Aprotinin; Benzamidines; Complement Inactivator Proteins; Gabexate; Glycoproteins; Guanidines; Hemolysis; In Vitro Techniques; Leupeptins; Protease Inhibitors; Protein Binding | 1986 |
[Clinical assessment of anticoagulation therapy during left ventricular assist with artificial heart: induction with protease inhibitor].
Topics: Aged; Assisted Circulation; Benzamidines; Drug Evaluation; Drug Therapy, Combination; Gabexate; Guanidines; Heart-Assist Devices; Heart, Artificial; Hemorrhage; Heparin; Humans; Middle Aged; Protease Inhibitors; Thrombosis | 1989 |
Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo.
Topics: Animals; Benzamidines; Dialysis; Endotoxins; Fibrinolytic Agents; Gabexate; Guanidines; Humans; In Vitro Techniques; Indicators and Reagents; Kinetics; Leukocytes; Male; N-Formylmethionine Leucyl-Phenylalanine; Pancreatic Elastase; Rats; Rats, Inbred Strains; Serine Proteinase Inhibitors; Thromboplastin | 1989 |
Studies on the effects of primary therapy for DIC following circulatory arrest.
Topics: Animals; Anticoagulants; Benzamidines; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Dogs; Fibrin Fibrinogen Degradation Products; Gabexate; Guanidines; Heart Arrest; Heparin; Platelet Count | 1986 |
New approach to management of chronic vascular rejection with prostacyclin analogue after kidney transplantation.
Topics: alpha-Cyclodextrins; Benzamidines; Blood Platelets; Cyclodextrins; Epoprostenol; Esters; Gabexate; Graft Rejection; Guanidines; Humans; Kidney; Kidney Transplantation; Vascular Diseases | 1987 |
[Problems in the use of newly introduced anti-shock agents].
Topics: Adrenal Cortex Hormones; Animals; Benzamidines; Complement Inactivator Proteins; Gabexate; Guanidines; Humans; Mice; Rats; Shock; Shock, Septic | 1983 |
The effect of nafamostat mesilate (FUT-175) and gabexate mesilate (FOY) on multiorgan oxidant-antioxidant balance in acute experimental pancreatitis.
Topics: Acute Disease; Animals; Benzamidines; Gabexate; Guanidines; Lung; Male; Malondialdehyde; Oxidative Stress; Pancreas; Pancreatitis; Rats; Rats, Wistar; Sulfhydryl Compounds; Taurocholic Acid | 1994 |
Effects of protease inhibitor and immunosuppressant on cerebral vasospasm after subarachnoid hemorrhage in rabbits.
Topics: Animals; Benzamidines; Betamethasone; Cyclosporine; Drug Administration Schedule; Gabexate; Guanidines; Ischemic Attack, Transient; Rabbits; Random Allocation; Serine Proteinase Inhibitors; Subarachnoid Hemorrhage | 1994 |
[The effects of synthetic protease inhibitor on motility of the human duodenal papilla].
Topics: Adult; Aged; Aged, 80 and over; Ampulla of Vater; Benzamidines; Depression, Chemical; Female; Gabexate; Gastrointestinal Motility; Guanidines; Humans; Male; Middle Aged; Protease Inhibitors | 1993 |
Comparative inhibitory effects of various nucleoside and nonnucleoside analogues on replication of influenza virus types A and B in vitro and in ovo.
Topics: Adenosine; Animals; Antiviral Agents; Benzamidines; Cells, Cultured; Chick Embryo; Dextran Sulfate; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Guanosine; Influenza A virus; Influenza B virus; Nucleosides; Protease Inhibitors; Ribavirin; Virus Replication | 1993 |
Systemic effects of epidermal growth factor (EGF) ointment containing protease inhibitor or gelatin in rats with burns or open wounds.
Topics: Animals; Aspartate Aminotransferases; Benzamidines; Body Weight; Burns; Drug Interactions; Drug Synergism; Epidermal Growth Factor; Epinephrine; Gabexate; Gelatin; Guanidines; Hydrocortisone; Male; Ointments; Protease Inhibitors; Rats; Rats, Wistar; Wounds and Injuries | 1993 |
Effects of protease inhibitors on postischemic recovery of the heart.
Topics: Animals; Benzamidines; Creatine Kinase; Gabexate; Glycoproteins; Guanidines; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Piperazines; Protease Inhibitors; Rats; Rats, Wistar | 1997 |
Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis.
Topics: Animals; Benzamidines; Capillary Permeability; Complement Inactivator Proteins; Evans Blue; Gabexate; Guanidines; Injections, Intra-Arterial; Injections, Intravenous; Lung; Male; Oligopeptides; Pancreas; Pancreatitis, Acute Necrotizing; Peritoneum; Peroxidase; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Survival Rate | 2001 |
Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid.
Topics: Aged; Benzamidines; Dalteparin; Drug Administration Schedule; Gabexate; Guanidines; Humans; Idarubicin; Kidney Neoplasms; Leukemia, Promyelocytic, Acute; Male; Nephritis, Interstitial; Prostatic Neoplasms; Thrombophilia; Tretinoin | 2001 |
Inhibition of natural killer cytotoxicity in vitro by clinical grade serine protease inhibitors.
Topics: Anti-Bacterial Agents; Antithrombin III; Benzamidines; Calcium; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Fluoresceins; Gabexate; Glycoproteins; Guanidines; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Macrolides; Serine Proteinase Inhibitors; Tumor Cells, Cultured | 2002 |
Changes in blood viscosity with synthetic protease inhibitors.
Topics: Adult; Benzamidines; Blood Viscosity; Dose-Response Relationship, Drug; Gabexate; Guanidines; Humans; Male; Protease Inhibitors | 2003 |
Involvement of proteinase-activated receptor-2 in mast cell tryptase-induced barrier dysfunction in bovine aortic endothelial cells.
Topics: Actins; Anaphylaxis; Animals; Antigens, CD; Aorta; Benzamidines; Cadherins; Calcium Signaling; Capillary Permeability; Cattle; Cells, Cultured; Contrast Media; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Evans Blue; Gabexate; Guanidines; Ioxaglic Acid; Receptor, PAR-2; Serine Endopeptidases; Stress Fibers; Tryptases | 2003 |
Nafamostat mesilate is an extremely potent inhibitor of human tryptase.
Topics: Benzamidines; Binding, Competitive; Dose-Response Relationship, Drug; Gabexate; Guanidines; Humans; Serine Endopeptidases; Serine Proteinase Inhibitors; Tryptases | 2003 |
Properties of poly(lactic-co-glycolic acid) nanospheres containing protease inhibitors: camostat mesilate and nafamostat mesilate.
Topics: Benzamidines; Chemistry, Pharmaceutical; Esters; Gabexate; Guanidines; Lactic Acid; Molecular Weight; Nanotubes; Particle Size; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Protease Inhibitors; Solubility | 2006 |
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
Topics: Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Benzamidines; Chemokines; Cysteine Endopeptidases; Cytokines; Eosinophilia; Female; Gabexate; Guanidines; Immunoglobulin E; Immunoglobulin G; Lung; Mast Cells; Mice; Mice, Inbred BALB C; NF-kappa B; RNA, Messenger; Serine Proteinase Inhibitors | 2006 |
Characteristics of gabexate mesilate-induced cell injury in porcine aorta endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Apoptosis; Benzamidines; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Endothelial Cells; Gabexate; Guanidines; Necrosis; Serine Proteinase Inhibitors; Swine | 2008 |
Refractory chronic urticaria treated effectively with the protease inhibitors, nafamostat mesilate and camostat mesilate.
Topics: Adult; Benzamidines; Chronic Disease; Drug Therapy, Combination; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Protease Inhibitors; Treatment Outcome; Urticaria | 2010 |
Nafamostat mesilate, a noncalcium compound, as an anticoagulant, induces calcium-dependent haemolysis when infused with packed erythrocytes.
Topics: Anticoagulants; Benzamidines; Calcium; Citrates; Citric Acid; Drug Evaluation, Preclinical; Edetic Acid; Erythrocyte Membrane; Erythrocytes; Flow Cytometry; Gabexate; Glucose; Guanidines; Hemoglobins; Hemolysis; Humans; In Vitro Techniques; Infusion Pumps; Infusions, Intravenous; L-Lactate Dehydrogenase; Membrane Lipids; Phosphatidylserines; Solutions | 2012 |
Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation.
Topics: Animals; Benzamidines; Cell Separation; Cell Survival; Gabexate; Gluconates; Glycoproteins; Guanidines; Hydroxyethyl Starch Derivatives; Islets of Langerhans; Phosphates; Swine; Trehalose; Trypsin; Trypsin Inhibitors | 2012 |
The effect of serine protease inhibitors on airway inflammation in a chronic allergen-induced asthma mouse model.
Topics: Allergens; Animals; Asthma; Benzamidines; Disease Models, Animal; Gabexate; Glycoproteins; Guanidines; Inflammation; Interleukin-13; Interleukin-17; Interleukin-4; Interleukin-5; Interleukin-6; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Serine Proteinase Inhibitors | 2014 |
Gibbs Free Energy of Hydrolytic Water Molecule in Acyl-Enzyme Intermediates of a Serine Protease: A Potential Application for Computer-Aided Discovery of Mechanism-Based Reversible Covalent Inhibitors.
Topics: Benzamidines; Binding Sites; Gabexate; Guanidines; Hydrolysis; Molecular Dynamics Simulation; Serine Proteases; Serine Proteinase Inhibitors; Thermodynamics; Water | 2017 |
Comparison of gabexate mesilate and nafamostat mesilate for disseminated intravascular coagulation associated with hematological malignancies.
Topics: Adult; Anticoagulants; Benzamidines; Disseminated Intravascular Coagulation; Female; Gabexate; Guanidines; Hematologic Neoplasms; Humans; Japan; Male; Middle Aged; Retrospective Studies; Serine Proteinase Inhibitors; Treatment Outcome | 2019 |
Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.
Topics: Antiviral Agents; Benzamidines; Betacoronavirus; Cells, Cultured; Coronavirus 229E, Human; Coronavirus Infections; COVID-19; Culture Media, Conditioned; Epithelial Cells; Esters; Gabexate; Guanidines; Humans; Nasal Mucosa; Pandemics; Pneumonia, Viral; Primary Cell Culture; Protease Inhibitors; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Viral Load; Virus Replication | 2020 |
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticoagulants; Benzamidines; Betacoronavirus; Cell Line; Chlorocebus aethiops; Coronavirus Infections; COVID-19; Esters; Gabexate; Guanidines; HEK293 Cells; Humans; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Vero Cells; Virus Internalization | 2020 |
Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
Topics: Antiviral Agents; Benzamidines; Betacoronavirus; Coronavirus Infections; COVID-19; Esters; Gabexate; Glycine; Guanidines; Humans; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Pandemics; Pneumonia, Viral; Protein Structure, Tertiary; SARS-CoV-2; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfonamides | 2020 |
Mechanisms of NMDA receptor inhibition by nafamostat, gabexate and furamidine.
Topics: Animals; Benzamidines; Drug Repositioning; Esters; Gabexate; Guanidines; Hippocampus; Inhibitory Concentration 50; Male; Models, Animal; Neurodegenerative Diseases; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine Proteinase Inhibitors | 2022 |
Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene.
Topics: Acid Sensing Ion Channels; Animals; Diminazene; Gabexate; Guanidines; Hydrogen-Ion Concentration; Rats | 2023 |
Inhibition of Listeria Monocytogenes HtrA Protease with Camostat, Gabexate and Nafamostat Mesylates and the Binding Mode of the Inhibitors.
Topics: COVID-19; Gabexate; Humans; Listeria monocytogenes; Mesylates; Peptide Hydrolases; Protease Inhibitors; RNA, Viral; SARS-CoV-2 | 2023 |