Compounds > gabapentin

gabapentin and idazoxan

gabapentin has been researched along with idazoxan in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Honda, M; Ono, H; Takasu, K; Tanabe, M1
Freiman, TM; Heinemeyer, J; Klar, M; Kukolja, J; Surges, R; van Velthoven, V; Zentner, J1
Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K1
Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY1
Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E1

Trials

1 trial(s) available for gabapentin and idazoxan

ArticleYear
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Analgesics, Opioid; Animals; Bee Venoms; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Idazoxan; Male; Morphine; Norepinephrine; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Time Factors

2007

Other Studies

6 other study(ies) available for gabapentin and idazoxan

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.
    British journal of pharmacology, 2006, Volume: 148, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Amines; Analgesics; Animals; Atropine; Cholinesterases; Cyclohexanecarboxylic Acids; Enzyme Activation; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Intraventricular; Male; Mice; Muscarinic Antagonists; Narcotic Antagonists; Neostigmine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Sciatic Nerve; Spinal Cord; Touch; Yohimbine

2006
K(+)-evoked [(3)H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil.
    Neuroscience research, 2006, Volume: 55, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Amines; Anticonvulsants; Brimonidine Tartrate; Calcium Channel Blockers; Child; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Humans; Idazoxan; In Vitro Techniques; Male; Middle Aged; Norepinephrine; omega-Conotoxins; Pinacidil; Potassium; Quinoxalines; Time Factors; Tritium

2006
Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Anticonvulsants; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gabapentin; gamma-Aminobutyric Acid; Idazoxan; Neuralgia; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord

2008
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
    Pain, 2017, Volume: 158, Issue:1

    Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constriction, Pathologic; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Hypnotics and Sedatives; Idazoxan; Male; Motor Activity; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

2017