g(m1)-ganglioside has been researched along with trimethyltin-chloride* in 1 studies
1 other study(ies) available for g(m1)-ganglioside and trimethyltin-chloride
| Article | Year |
|---|---|
GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study.
This study demonstrates potentiation by GM1 ganglioside treatment of trimethyltin (TMT) induced reactivity of astrocytes, and the expression of astroglial interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) immunoreactivities in the rat hippocampus. GM1 treatment also results in an increase of the number of IL-1 beta and NGF immunoreactive astrocytes. Both the intensity of gliosis and stimulation of IL-1 beta and NGF expression in astrocytes mostly occurs in the regions of heaviest neurodegeneration in the hippocampus (CA4/CA3c and CA1). It is tempting to assume that enhancement of astroglial NGF expression by GM1 ganglioside may play a role in the protective action of GM1 against neurotoxic insult. Topics: Animals; Astrocytes; Drug Synergism; G(M1) Ganglioside; Hippocampus; Immunohistochemistry; Injections, Intramuscular; Injections, Intraperitoneal; Interleukin-1; Male; Nerve Growth Factors; Rats; Rats, Wistar; Trimethyltin Compounds | 1998 |