Page last updated: 2024-09-04

fusidic acid and trimethoprim

fusidic acid has been researched along with trimethoprim in 33 studies

Compound Research Comparison

Studies
(fusidic acid)
Trials
(fusidic acid)
Recent Studies (post-2010)
(fusidic acid)
Studies
(trimethoprim)
Trials
(trimethoprim)
Recent Studies (post-2010) (trimethoprim)
1,7421173446,989845894

Protein Interaction Comparison

ProteinTaxonomyfusidic acid (IC50)trimethoprim (IC50)
Chain A, Dihydrofolate reductaseBacillus anthracis77200
Chain A, dihydrofolate reductase (DHFR)Bacillus anthracis77200
Dihydrofolate reductase Mycobacterium avium0.2588
Dihydrofolate reductaseHomo sapiens (human)1.8206
Dihydrofolate reductaseLacticaseibacillus casei0.3493
Dihydrofolate reductase type 1Escherichia coli0.25
Dihydrofolate reductaseNeisseria gonorrhoeae0.45
Thymidylate synthaseHomo sapiens (human)3.405
Dihydrofolate reductaseStaphylococcus aureus0.0875
Thymidylate synthaseEscherichia coli K-123.405
Dihydrofolate reductaseEscherichia coli K-120.6064
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K10.01
Dihydrofolate reductase type 1 from Tn4003Staphylococcus aureus0.023
Dipeptidyl peptidase 4Rattus norvegicus (Norway rat)2.7
Dihydrofolate reductasePneumocystis carinii0.7061
Dihydrofolate reductaseCandida albicans0.1361
Dipeptidyl peptidase 4Homo sapiens (human)2.7
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.45
Metabotropic glutamate receptor 5Rattus norvegicus (Norway rat)2.73
Mu-type opioid receptorCavia porcellus (domestic guinea pig)2.8
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii3.2206
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium berghei ANKA0.12
Dihydrofolate reductaseStreptococcus pneumoniae TIGR40.0297
Dihydrofolate reductaseLactococcus lactis subsp. lactis Il14030.45
Dihydrofolate reductase Bacillus anthracis4.77
Dihydrofolate reductaseRattus norvegicus (Norway rat)1.244
Dihydrofolate reductase Pneumocystis jirovecii0.092

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199018 (54.55)18.7374
1990's3 (9.09)18.2507
2000's5 (15.15)29.6817
2010's7 (21.21)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Cho, SH; Franzblau, SG; Hwang, CH; Pauli, GF; Wan, B; Warit, S1
Arpin, C; Fournier, M; Gagné, S; Hernould, M; Quentin, C1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bavari, S; Bowlin, TL; Houseweart, C; Moir, DT; Opperman, TJ; Panchal, RG; Peet, NP; Williams, JD1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Floyd, JL; Floyd, JT; Kumar, SH; Smith, KP; Varela, MF1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Ashenden, S; Bender, A; Cokol, M; Karakoc, I; Kuru, N; Mason, DJ; Meral, S; Stott, I; Weinstein, ZB1
Hamilton-Miller, JM1
Benn, RA1
Isaksson, LA; Takata, R1
Darrell, JH; Uttley, AH1
Hossack, G; Paddock, G; Parsons, RL1
Gibson, JR; Harvey, SG; Jaafar, RB; Lumpur, K; Marks, P; Pettit, JH1
Chandrasekar, PH; DeLorenzo, W; Levine, DP; Unowsky, J1
Nielsen, H1
Natunen, T; Saunders, L1
Jeljaszewicz, J; Lund, E; Pulverer, G1
Pulverer, G1
Jeljaszewicz, J; Pulverer, G1
Lacey, RW; Richmond, MH1
Kjeldgaard, NO; Lund, E1
Derambure, S; Deroubaix, P; Hogedez, G; Lelong, M; Polaert, J; Sorez, JP; Thelliez, P; Vanlaeys, R1
Plommet, M; Taylor, AG1
Vacek, V1
Nakhla, LS1
Emmerson, AM; Grüneberg, RN; Ridgway, GL1
Hay, RJ; Nasher, MA1
Bourdeau, P; Pellerin, JL; Person, JM; Sebbag, H1
Berger-Bächi, B; Ender, M; McCallum, N1
Brennan, OM; Coleman, DC; Deasy, EC; Ehricht, R; Kinnevey, PM; Monecke, S; Rossney, AS; Shore, AC1

Reviews

3 review(s) available for fusidic acid and trimethoprim

ArticleYear
Antimicrobial agents acting against anaerobes.
    The Journal of antimicrobial chemotherapy, 1975, Volume: 1, Issue:3

    Topics: Aminoglycosides; Anaerobiosis; Animals; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Clindamycin; Colistin; Disease Models, Animal; Erythromycin; Fusidic Acid; Humans; Lactams; Lincomycin; Microbial Sensitivity Tests; Nitrofurans; Nitroimidazoles; Polymyxins; Rifamycins; Sulfamethoxazole; Tetracyclines; Trimethoprim; Vancomycin

1975
Antibiotics: use and abuse in office practice.
    Drugs, 1977, Volume: 13, Issue:4

    Topics: Anti-Bacterial Agents; Cephalosporins; Clindamycin; Erythromycin; Fusidic Acid; Humans; Kidney Diseases; Lincomycin; Mycoplasma Infections; Penicillins; Private Practice; Respiratory Tract Infections; Skin Diseases, Infectious; Staphylococcal Infections; Streptococcal Infections; Substance-Related Disorders; Sulfonamides; Tetracyclines; Trimethoprim

1977
Antibiotics in the peri-operative period.
    British journal of anaesthesia, 1976, Volume: 48, Issue:1

    Topics: Acute Kidney Injury; Aminoglycosides; Anesthesia; Anti-Bacterial Agents; Bronchitis; Cephalosporins; Drug Combinations; Endocarditis, Bacterial; Fusidic Acid; Gentamicins; Humans; Infusions, Parenteral; Lincomycin; Penicillins; Pneumonia; Postoperative Complications; Rifamycins; Staphylococcal Infections; Sulfamethoxazole; Surgical Procedures, Operative; Tetracyclines; Trimethoprim; Urinary Tract Infections

1976

Trials

1 trial(s) available for fusidic acid and trimethoprim

ArticleYear
Trimethoprim-polymyxin B sulfate cream versus fusidic acid cream in the treatment of pyodermas: an update.
    International journal of dermatology, 1991, Volume: 30, Issue:10

    Topics: Double-Blind Method; Drug Combinations; Female; Fusidic Acid; Humans; Male; Polymyxin B; Pyoderma; Trimethoprim

1991

Other Studies

29 other study(ies) available for fusidic acid and trimethoprim

ArticleYear
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Anti-Bacterial Agents; Antitubercular Agents; DNA, Bacterial; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Oxygen

2007
Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Aeromonas hydrophila; Anti-Bacterial Agents; Bacterial Proteins; Biological Transport, Active; Dipeptides; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA; Substrate Specificity

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Bacterial Proteins; Drug Resistance, Bacterial; Indoles; Microbial Sensitivity Tests; Mutation; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcus aureus; Structure-Activity Relationship; Substrate Specificity

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Amino Acid Sequence; Bacterial Proteins; Chloramphenicol; Drug Resistance, Multiple, Bacterial; Ethidium; Membrane Transport Proteins; Microbial Sensitivity Tests; Molecular Sequence Data; Onium Compounds; Organophosphorus Compounds; Phylogeny; Sequence Homology, Amino Acid; Sodium Dodecyl Sulfate; Staphylococcus aureus; Trimethoprim; Vancomycin

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure.
    Journal of medicinal chemistry, 2017, 05-11, Volume: 60, Issue:9

    Topics: Anti-Bacterial Agents; Drug Interactions; Molecular Structure

2017
The temperature sensitive mutant 72c. I. Pleiotropic growth behaviour and changed response to some antibiotics and mutations in the transcription or translation apparatus.
    Molecular & general genetics : MGG, 1978, Apr-25, Volume: 161, Issue:1

    Topics: Chloramphenicol; Chromosome Mapping; Chromosomes, Bacterial; Escherichia coli; Fusidic Acid; Genes; Mutation; Phenotype; Protein Biosynthesis; Transcription, Genetic; Trimethoprim

1978
The absorption of antibiotics in adult patients with coeliac disease.
    The Journal of antimicrobial chemotherapy, 1975, Volume: 1, Issue:1

    Topics: Adult; Amoxicillin; Ampicillin; Anti-Bacterial Agents; Celiac Disease; Cephalexin; Clindamycin; Erythromycin; Ethics, Medical; Fusidic Acid; Humans; Intestinal Absorption; Lincomycin; Pivampicillin; Rifampin; Sulfamethoxazole; Trimethoprim

1975
In vitro and in vivo activity of coumermycin and other antibacterial agents against methicillin-resistant strains of Staphylococcus aureus.
    Chemotherapy, 1986, Volume: 32, Issue:6

    Topics: Aminocoumarins; Animals; Anti-Bacterial Agents; Coumarins; Drug Combinations; Female; Fusidic Acid; Methicillin; Mice; Microbial Sensitivity Tests; Neutropenia; Penicillin Resistance; Staphylococcal Infections; Staphylococcus aureus; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin

1986
Antibiotics and human monocyte function. I. Chemotaxis.
    Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology, 1987, Volume: 95, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Chemotaxis, Leukocyte; Female; Fusidic Acid; Humans; Male; Monocytes; Tetracycline; Trimethoprim

1987
A stable method for calculating oral drug absorption rate constants with two compartment disposition.
    The Journal of pharmacy and pharmacology, 1973, Volume: 25

    Topics: Administration, Oral; Animals; Dogs; Fusidic Acid; Humans; Intestinal Absorption; Kinetics; Mathematics; Pharmaceutical Preparations; Pyridines; Time Factors; Trimethoprim

1973
Serological types of Diplococcus pneumoniae strains isolated in Germany. Comparison with type patterns in other countries.
    Medical microbiology and immunology, 1974, Mar-22, Volume: 159, Issue:3

    Topics: Cephaloridine; Chloramphenicol; Drug Combinations; Erythromycin; Fusidic Acid; Germany, West; Humans; Lincomycin; Microbial Sensitivity Tests; Nitrofurans; Novobiocin; Penicillin Resistance; Penicillins; Respiratory Tract Infections; Serotyping; Sputum; Streptococcus pneumoniae; Sulfamethoxazole; Sulfonamides; Tetracycline; Trimethoprim; Vancomycin

1974
[Actual medical importance and antibiotic resistance of staphylococci].
    Deutsche medizinische Wochenschrift (1946), 1972, Feb-18, Volume: 97, Issue:7

    Topics: Ampicillin; Cephaloridine; Chloramphenicol; Erythromycin; Fusidic Acid; Gentamicins; Germany, West; Lincomycin; Novobiocin; Oxacillin; Penicillin G; Penicillin Resistance; Staphylococcus; Streptomycin; Sulfamethoxazole; Tetracycline; Trimethoprim; Vancomycin

1972
Geographical differences in antibiotic sensitivity patterns: comparison of susceptibility of staphylococci in Poland and Germany.
    Medical microbiology and immunology, 1973, Mar-08, Volume: 158, Issue:3

    Topics: Cephaloridine; Chloramphenicol; Erythromycin; Framycetin; Fusidic Acid; Geography; Germany, West; Kanamycin; Lincomycin; Nitrofurantoin; Penicillin Resistance; Penicillins; Poland; Rifampin; Species Specificity; Staphylococcus; Streptomycin; Sulfamethoxazole; Tetracycline; Trimethoprim

1973
The genetic basis of antibiotic resistance in S. aureus: the importance of gene transfer in the evolution of this organism in the hospital environment.
    Annals of the New York Academy of Sciences, 1974, Jul-31, Volume: 236, Issue:0

    Topics: Anti-Bacterial Agents; Cloxacillin; Cross Infection; DNA, Bacterial; Extrachromosomal Inheritance; Fusidic Acid; Genes; Genetic Linkage; Humans; Methicillin; Novobiocin; Penicillin Resistance; Penicillinase; Skin; Staphylococcal Infections; Staphylococcus; Streptomycin; Transduction, Genetic; Transformation, Genetic; Trimethoprim

1974
Metabolism of guanosine tetraphosphate in Escherichia coli.
    European journal of biochemistry, 1972, Jul-24, Volume: 28, Issue:3

    Topics: Amino Acyl-tRNA Synthetases; Bacterial Proteins; Chloramphenicol; Colicins; Depression, Chemical; Erythromycin; Escherichia coli; Fusidic Acid; Guanine Nucleotides; Hot Temperature; Hydroxylamines; Peptide Chain Initiation, Translational; Puromycin; Rifampin; RNA, Bacterial; Streptomycin; Tetracycline; Trimethoprim; Valine

1972
[Antibiotic resistance of Staphylococcus aureus isolated rom children. Comparative evolution between 1967 and 1972].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1973, Volume: 18, Issue:4

    Topics: Adolescent; Anti-Bacterial Agents; Cephalosporins; Child; Child, Preschool; Drug Resistance, Microbial; Fusidic Acid; Gastroenteritis; Gentamicins; Humans; Infant; Otitis; Respiratory Tract Infections; Skin Diseases; Staphylococcal Food Poisoning; Staphylococcal Infections; Sulfamethoxazole; Trimethoprim; Virginiamycin

1973
Anti-gamma haemolysin as a diagnostic test in staphylococcal osteomyelitis.
    Journal of clinical pathology, 1973, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromatography, DEAE-Cellulose; Female; Fusidic Acid; Hemolysin Proteins; Hemolysis; Humans; Immunoglobulin G; Male; Middle Aged; Osteomyelitis; Staphylococcal Infections; Sulfamethoxazole; Trimethoprim

1973
Clinical value of antistaphylococcal drugs.
    Contributions to microbiology and immunology, 1973, Volume: 1

    Topics: Acute Disease; Anti-Infective Agents; Cephalosporins; Chronic Disease; Czechoslovakia; Drug Evaluation; Endocarditis, Bacterial; Erythromycin; Fusidic Acid; Gentamicins; Humans; Lincomycin; Novobiocin; Osteomyelitis; Penicillins; Recurrence; Rifamycins; Staphylococcal Infections; Sulfamethoxazole; Trimethoprim; Vancomycin

1973
Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim.
    Journal of clinical pathology, 1972, Volume: 25, Issue:8

    Topics: Anti-Bacterial Agents; Bacitracin; Bacteriophage Typing; Drug Resistance, Microbial; Folic Acid Antagonists; Fusidic Acid; Humans; Lincomycin; Microbial Sensitivity Tests; Neomycin; Oleandomycin; Penicillin Resistance; Pyrimidines; Staphylococcus; Streptomycin; Sulfamethoxazole; Sulfonamides; Tetracycline; Trimethoprim

1972
Rifampicin-containing antibiotic combinations in the treatment of difficult infections.
    The Journal of antimicrobial chemotherapy, 1984, Volume: 13 Suppl C

    Topics: Adolescent; Adult; Aged; Bacterial Infections; Drug Therapy, Combination; Erythromycin; Female; Fusidic Acid; Humans; Infant; Legionnaires' Disease; Male; Meningitis; Middle Aged; Osteomyelitis; Rifampin; Sepsis; Skin Diseases, Infectious; Staphylococcal Infections; Tetracycline; Trimethoprim

1984
Synergy of antibiotics against Streptomyces somaliensis isolates in vitro.
    The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:2

    Topics: Drug Therapy, Combination; Erythromycin; Fusidic Acid; Microbial Sensitivity Tests; Penicillins; Rifampin; Streptomyces; Sulfamethoxazole; Trimethoprim

1998
Epidemiosurveillance of antimicrobial compound resistance of Staphylococcus intermedium clinical isolates from canine pyodermas.
    Comparative immunology, microbiology and infectious diseases, 1998, Volume: 21, Issue:2

    Topics: Aminoglycosides; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Cephalexin; Chloramphenicol; Dog Diseases; Dogs; Drug Combinations; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; Fluoroquinolones; France; Fusidic Acid; Macrolides; Microbial Sensitivity Tests; Oxacillin; Pyoderma; Retrospective Studies; Sentinel Surveillance; Staphylococcal Infections; Staphylococcus; Sulfadiazine; Tetracyclines; Trimethoprim

1998
Variability in SCCmecN1 spreading among injection drug users in Zurich, Switzerland.
    BMC microbiology, 2007, Jul-02, Volume: 7

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Ciprofloxacin; Deoxyribonucleases, Type II Site-Specific; DNA Fingerprinting; DNA Transposable Elements; DNA, Bacterial; Fusidic Acid; Humans; Interspersed Repetitive Sequences; Methicillin; Methicillin Resistance; Molecular Epidemiology; Molecular Sequence Data; Penicillin-Binding Proteins; Polymorphism, Restriction Fragment Length; Staphylococcal Infections; Staphylococcus aureus; Substance Abuse, Intravenous; Switzerland; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

2007
DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent id
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:10

    Topics: Bacterial Proteins; Fusidic Acid; Methicillin-Resistant Staphylococcus aureus; Multilocus Sequence Typing; Oligonucleotide Array Sequence Analysis; Trimethoprim

2012