Page last updated: 2024-09-04

fusidic acid and ketoconazole

fusidic acid has been researched along with ketoconazole in 17 studies

Compound Research Comparison

Studies
(fusidic acid)
Trials
(fusidic acid)
Recent Studies (post-2010)
(fusidic acid)
Studies
(ketoconazole)
Trials
(ketoconazole)
Recent Studies (post-2010) (ketoconazole)
1,7421173446,2027061,269
1,7421173441490120

Protein Interaction Comparison

ProteinTaxonomyfusidic acid (IC50)ketoconazole (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)2.6
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialHomo sapiens (human)0.34
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialMus musculus (house mouse)0.36
Bile salt export pumpHomo sapiens (human)3.44
Steroid 17-alpha-hydroxylase/17,20 lyaseHomo sapiens (human)1.5811
ATP-dependent translocase ABCB1Mus musculus (house mouse)6.7
ATP-dependent translocase ABCB1Homo sapiens (human)4.6771
Cytochrome P450 3A4Homo sapiens (human)0.2303
Steroid 21-hydroxylaseHomo sapiens (human)6.655
Cytochrome P450 2C8Homo sapiens (human)0.06
AromataseHomo sapiens (human)1.4111
Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Norway rat)2.0802
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)5.425
Cholesterol side-chain cleavage enzyme, mitochondrial Rattus norvegicus (Norway rat)3.32
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)1.067
Cytochrome P450 2A2Rattus norvegicus (Norway rat)0.456
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)0.38
Cytochrome P450 11B1, mitochondrialHomo sapiens (human)0.4519
Translocator proteinRattus norvegicus (Norway rat)3.76
Cytochrome P450 7A1 Rattus norvegicus (Norway rat)1.2975
Cytochrome P450 11B2, mitochondrialHomo sapiens (human)0.5179
ATP-dependent translocase ABCB1Mus musculus (house mouse)3.8
Thromboxane-A synthase Homo sapiens (human)2.165
Gonadotropin-releasing hormone receptorRattus norvegicus (Norway rat)2
Sodium-dependent serotonin transporterHomo sapiens (human)0.531
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.0078
Cytochrome P450 4F2Homo sapiens (human)1.6
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialHomo sapiens (human)0.4144
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.9036
Lanosterol 14-alpha demethylaseHomo sapiens (human)0.19
Cytochrome P450 7A1Mus musculus (house mouse)1.2975
Lanosterol 14-alpha demethylase Rattus norvegicus (Norway rat)0.083
Epoxide hydrolase 1 Homo sapiens (human)0.04
Cytochrome P450 2D6Homo sapiens (human)2.774
Cytochrome P450 3A5Homo sapiens (human)0.2535
Bifunctional epoxide hydrolase 2Homo sapiens (human)0.04
Sterol 14-alpha demethylaseTrypanosoma cruzi strain CL Brener0.014

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19909 (52.94)18.7374
1990's0 (0.00)18.2507
2000's3 (17.65)29.6817
2010's4 (23.53)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Cho, SH; Franzblau, SG; Hwang, CH; Pauli, GF; Wan, B; Warit, S1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Pagliano, F1
Bianchi, G1
Pellerano, S1
Pazzaglia, A2
Gini, M1
Franchi, G1
Marras, F1
Scremin, S1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF1

Reviews

1 review(s) available for fusidic acid and ketoconazole

ArticleYear
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells

2022

Trials

1 trial(s) available for fusidic acid and ketoconazole

ArticleYear
Use of a combination of an anti-inflammatory steroid, an antibacterial agent and an antifungal in dermatological practice.
    International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:4

    Topics: Administration, Topical; Adolescent; Adult; Aged; Betamethasone; Clinical Trials as Topic; Clobetasol; Drug Therapy, Combination; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases

1985

Other Studies

15 other study(ies) available for fusidic acid and ketoconazole

ArticleYear
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Anti-Bacterial Agents; Antitubercular Agents; DNA, Bacterial; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Oxygen

2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Treatment of skin diseases of mixed aetiology in outpatients.
    International journal of tissue reactions, 1986, Volume: 8, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Aged; Bacterial Infections; Beclomethasone; Child; Dermatitis, Contact; Dermatomycoses; Drug Combinations; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases; Skin Diseases, Infectious

1986
Multivalent treatment of skin diseases in infants and young children.
    Drugs under experimental and clinical research, 1985, Volume: 11, Issue:11

    Topics: Administration, Topical; Bacterial Infections; Beclomethasone; Child; Child, Preschool; Dermatomycoses; Diaper Rash; Drug Therapy, Combination; Female; Fusidic Acid; Humans; Infant; Ketoconazole; Male; Skin Diseases

1985
Clinical results obtained with a combination of an anti-inflammatory steroid, an antibacterial agent and an antifungal in dermatological outpatient practice.
    International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:7

    Topics: Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Antifungal Agents; Beclomethasone; Drug Combinations; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases

1985
Use of a combination of an anti-inflammatory corticosteroid, an antibacterial agent and an antifungal in the local post-operative treatment of cutaneo-mucosal diseases following cryosurgery.
    International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Antifungal Agents; Beclomethasone; Child; Combined Modality Therapy; Cryosurgery; Drug Combinations; Erythema; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases

1985
Treatment of dermatological conditions with a combination of an antibacterial agent, an antifungal agent and an antiinflammatory steroid.
    International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:9

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Child; Child, Preschool; Clobetasol; Dermatologic Agents; Drug Therapy, Combination; Female; Fusidic Acid; Humans; Infant; Ketoconazole; Male; Middle Aged; Skin Diseases

1985
Therapeutic effects and tolerance of an extempore combination of an antibacterial, an anti-inflammatory, and an antimycotic cream in skin diseases of various origins.
    Pharmatherapeutica, 1985, Volume: 4, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Antifungal Agents; Child; Child, Preschool; Clobetasol; Drug Combinations; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases

1985
Therapeutic usefulness of a corticosteroid, antibacterial and antifungal combination in skin diseases of various origins.
    Pharmatherapeutica, 1985, Volume: 4, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Infective Agents, Local; Antifungal Agents; Clobetasol; Drug Combinations; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases, Infectious

1985
Treatment of skin diseases of various origins with a multi-action drug combination.
    Pharmatherapeutica, 1985, Volume: 4, Issue:5

    Topics: Administration, Topical; Adolescent; Adult; Aged; Beclomethasone; Drug Combinations; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases; Time Factors

1985