fuscin has been researched along with 8-hydroxyguanine* in 1 studies
1 other study(ies) available for fuscin and 8-hydroxyguanine
| Article | Year |
|---|---|
Mediation of 8-hydroxy-guanine formation in DNA by thiazin dyes plus light.
We have discovered that methylene blue plus light mediates the formation of 8-OHdG in DNA. Methylene blue is one of several thiazin dyes and we report here that the other thiazin dyes tested, in combination with white light, are effective in mediating 8-OHdG formation in DNA. The effectiveness of light plus the thiazin dyes in forming 8-OHdG in DNA were as follows: methylene blue greater than azure B greater than azure A greater than toluidine blue greater than thionin. Two other compounds tested; riboflavin and fuschin acid, in combination with light, caused formation of very little, if any, 8-OHdG in DNA. Thiazin dye mediated formation of 8-OHdG in DNA was not inhibited by the spin trap alpha-phenyl-t-butyl nitrone, which supports our previous observations that oxygen free radical scavengers did not inhibit methylene blue plus light mediated 8-OHdG formation in DNA. Ascorbate addition to methylene blue plus DNA, in the absence of light, was ineffective in mediating 8-OHdG formation in DNA. Topics: Animals; Azure Stains; Benzopyrans; Cattle; Coloring Agents; Cyclic N-Oxides; DNA; Free Radicals; Guanine; Light; Methylene Blue; Nitrogen Oxides; Phenothiazines; Riboflavin; Tolonium Chloride | 1990 |