furosemide and metformin

furosemide has been researched along with metformin in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.63)	18.2507
2000's	7 (18.42)	29.6817
2010's	25 (65.79)	24.3611
2020's	5 (13.16)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Darvesh, AS; Geldenhuys, WJ; Leeper, TC; Morris, DL; Sullivan, PG; Yonutas, HM	1
Barclay, SC; Gibson, J; Lamey, PJ; Miller, S	1
Berner, B; Cowles, VE	1
Cvijić, S; Langguth, P; Parojčić, J	1
Ebner, T; Ishiguro, N; Taub, ME	1
Gillen, M; Kerr, B; Shen, Z; Wallach, K; Yeh, LT; Zhu, N	1
Ebner, T; Gansser, D; Giessmann, T; Hohl, K; Ishiguro, N; Müller, F; Sharma, A; Stopfer, P; Taub, ME; Wein, M; Zimdahl-Gelling, H	1
Ebner, T; Gansser, D; Giessmann, T; Hohl, K; Ishiguro, N; Jungnik, A; Müller, F; Sharma, A; Stopfer, P; Taub, ME	1
Luo, X; Ma, YR; Wu, XA; Wu, YF; Zhang, F; Zhang, GQ; Zhang, T	1
Hernandez-Illas, M; Katsube, T; Miyazaki, S; Narukawa, Y; Wajima, T	1
Ebner, T; Gansser, D; Giessmann, T; Hohl, K; Hutzel, S; Ishiguro, N; Müller, F; Schmidt, S; Sharma, A; Stopfer, P; Taub, ME	1
Apicella, A; Beretta, E; Della Morte, M; Ferrario, M	1
Chen, S; Du, B; Guo, XL; Han, QJ; Hao, GX; Kan, M; Nie, AQ; Shi, HY; Tang, BH; Ye, PP; Zhao, W; Zheng, Y; Zhou, Y	1
Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE	1
Attakora, J; Donkoh, IE; Ephraim, RKD; Essuman, G; Okyere, I; Okyere, P; Serwaa, D	1
Alsharaa, A; Alwayn, IPJ; de Vries, A; Donkers, JM; Doppenberg, JB; Dubbeld, J; Knibbe, CAJ; Menke, AL; Stevens, LJ; Vaes, WHJ; van de Steeg, E; van Hoek, B	1
Ali, N; El-Shazly, AM; Hasan, RA; Mahmoud, MF; Sobeh, M; Tawfeek, N	1

Reviews

2 review(s) available for furosemide and metformin

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for furosemide and metformin

Article	Year
Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin. Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:3 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cation Transport Proteins; Cross-Over Studies; Digoxin; Drug Interactions; Furosemide; Humans; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Metformin; Middle Aged; Neoplasm Proteins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3	2016
Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail. European journal of drug metabolism and pharmacokinetics, 2018, Volume: 43, Issue:1 Topics: Adolescent; Adult; Anticholesteremic Agents; Biological Availability; Cross-Over Studies; Diuretics; Dose-Response Relationship, Drug; Drug Interactions; Furosemide; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Rosuvastatin Calcium; Young Adult	2018
Drug-drug interaction of cefiderocol, a siderophore cephalosporin, via human drug transporters. European journal of clinical pharmacology, 2018, Volume: 74, Issue:7 Topics: Adolescent; Adult; Biological Transport; Cefiderocol; Cephalosporins; Cross-Over Studies; Drug Interactions; Female; Furosemide; Humans; Male; Membrane Transport Proteins; Metformin; Middle Aged; Rosuvastatin Calcium; Siderophores; Young Adult	2018
Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions. British journal of clinical pharmacology, 2018, Volume: 84, Issue:9 Topics: Adult; Area Under Curve; Cross-Over Studies; Digoxin; Dose-Response Relationship, Drug; Drug Development; Drug Interactions; Furosemide; Healthy Volunteers; Humans; Male; Membrane Transport Proteins; Metformin; Middle Aged; Renal Elimination; Rosuvastatin Calcium; Young Adult	2018

Other Studies

32 other study(ies) available for furosemide and metformin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Identification of small molecules that bind to the mitochondrial protein mitoNEET. Bioorganic & medicinal chemistry letters, 2016, 11-01, Volume: 26, Issue:21 Topics: Hypoglycemic Agents; Ligands; Mitochondrial Proteins; Protein Binding; Small Molecule Libraries; Thiazolidinediones	2016
Grinspan's syndrome: a drug-induced phenomenon? Oral surgery, oral medicine, and oral pathology, 1990, Volume: 70, Issue:2 Topics: Aged; Aged, 80 and over; Atenolol; Bendroflumethiazide; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Female; Furosemide; Glipizide; Humans; Hypertension; Lichen Planus; Metformin; Middle Aged; Mouth Diseases; Spironolactone; Syndrome	1990
Case studies in swelling polymeric gastric retentive tablets. Expert opinion on drug delivery, 2006, Volume: 3, Issue:4 Topics: Administration, Oral; Ciprofloxacin; Drug Carriers; Furosemide; Gastrointestinal Tract; Humans; Metformin; Polymers; Tablets, Enteric-Coated	2006
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Sep-30, Volume: 61 Topics: Administration, Oral; Atenolol; Food; Food-Drug Interactions; Furosemide; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Metformin; Permeability; Reproducibility of Results; Solubility; Viscosity	2014
The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail. Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:9 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cell Line; Cell Line, Tumor; Digoxin; Drug Interactions; Furosemide; HEK293 Cells; Humans; Metformin; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transport Proteins; Rosuvastatin Calcium	2015
In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clinical drug investigation, 2016, Volume: 36, Issue:6 Topics: Adolescent; Adult; Aged; Atorvastatin; Carrier Proteins; Cell Line; Diuretics; Drug Interactions; Furosemide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kidney; Liver; Liver-Specific Organic Anion Transporter 1; Male; Metformin; Middle Aged; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult	2016
Alteration of renal excretion pathways in gentamicin-induced renal injury in rats. Journal of applied toxicology : JAT, 2018, Volume: 38, Issue:7 Topics: Acute Kidney Injury; Animals; Antiporters; ATP Binding Cassette Transporter, Subfamily G, Member 2; Disease Models, Animal; Furosemide; Gentamicins; Glomerular Filtration Rate; Inulin; Kidney; Male; Membrane Transport Proteins; Metformin; Multidrug Resistance-Associated Proteins; Organic Cation Transport Proteins; p-Aminohippuric Acid; Rats, Wistar; Renal Elimination	2018
[A case of severe metformin-associated lactic acidosis treated with CVVHDF and regional anticoagulation with sodium citrate]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2018, Volume: 35, Issue:5 Topics: Acidosis, Lactic; Aged; Anticoagulants; Bronchial Spasm; Combined Modality Therapy; Female; Furosemide; Hemodiafiltration; Humans; Hypoglycemic Agents; Hypotension; Metformin; Piperacillin, Tazobactam Drug Combination; Sodium Bicarbonate; Sodium Citrate	2018
Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration. Pharmaceutical research, 2020, Aug-02, Volume: 37, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Digoxin; Furosemide; Gene Expression Regulation; Glomerular Filtration Rate; Humans; Kidney; Male; Metformin; Mice, Inbred NOD; Mice, SCID; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Elimination; Tandem Mass Spectrometry	2020
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care. Drug safety, 2022, Volume: 45, Issue:11 Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia; Case-Control Studies; Ciprofloxacin; Diclofenac; Furosemide; Humans; Ibuprofen; Metformin; Naproxen; Omeprazole; Primary Health Care; Ramipril; Simvastatin; Spironolactone; Sulfamethoxazole; Telmisartan; Trimethoprim; Valacyclovir; Zoledronic Acid	2022
Conservative therapy is associated with worse clinical features and biochemical derangements than renal replacement therapy: a retrospective study in Kumasi, Ghana. BMC nephrology, 2022, 10-26, Volume: 23, Issue:1 Topics: Adult; Aspirin; Bisoprolol; Conservative Treatment; Furosemide; Ghana; Humans; Irbesartan; Kidney Failure, Chronic; Lisinopril; Metformin; Middle Aged; Nifedipine; Ranitidine; Renal Replacement Therapy; Retrospective Studies; Sodium	2022
Novel Explanted Human Liver Model to Assess Hepatic Extraction, Biliary Excretion and Transporter Function. Clinical pharmacology and therapeutics, 2023, Volume: 114, Issue:1 Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Digoxin; Drug Interactions; Furosemide; Hepatobiliary Elimination; Humans; Liver; Liver Cirrhosis; Membrane Transport Proteins; Metformin; Neoplasm Proteins; Rosuvastatin Calcium	2023
Salix babylonica L. mitigates pancreatic damage by regulating the Beclin-P62/SQSTM1 autophagy pathway in rats. Journal of ethnopharmacology, 2023, Sep-15, Volume: 313 Topics: Animals; Autophagy; Dexamethasone; Metformin; Oxidative Stress; Pancreas; Rats; Rats, Wistar; Salix; Sequestosome-1 Protein	2023