furosemide and acetaminophen

furosemide has been researched along with acetaminophen in 83 studies

Research

Studies (83)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (26.51)	18.7374
1990's	3 (3.61)	18.2507
2000's	24 (28.92)	29.6817
2010's	26 (31.33)	24.3611
2020's	8 (9.64)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Chang, TK; Ensom, MH; Kiang, TK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Akamatsu, M	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Richens, A	1
Jollow, DJ; Mitchell, JR; Potter, WZ; Sasame, HA; Thorgeirsson, SS	1
Mitchell, JR; Potter, WZ; Sasame, HA; Thorgeirsson, SS	1
Dybing, E	3
Mitchell, JR; Potter, WZ	1
Dybing, E; Mitchell, JR	1
Levine, L	1
D'Angelo, LJ	1
Dybing, E; McMurtry, RJ; Mitchell, JR; Nelson, SD; Thorgeirsson, SS	1
McMurtry, RJ; Mitchell, JR; Nelson, SD; Statham, CN	1
Gillette, JR; Mitchell, JR; Snodgrass, WR	1
Jollows, DJ; Mitchell, JR	1
Cefalo, RC; Katz, VL; Peterson, R	1
Adamson, GM; Harman, AW	1
Bock, GR; Miller, JJ; Moorjani, PA	1
Gillette, JR	2
Hughes, H; Mitchell, JR; Smith, CV	1
D'Arcy, PF	1
Kern, F; Mallory, A	1
de Villiers, MM	1
Martin, U; Prescott, LF	1
Hayball, PJ; Henderson, G; Latimer, K; May, F; Rowett, D; Ruffin, RE; Sansom, LN	1
Rogers, LK; Smith, CV; Szczpyka, M; Valentine, CJ	1
Casalderrey, M; Concheiro, A; Gómez-Amoza, JL; Martínez-Pacheco, R; Souto, C	1
Bruculeri, C; Chou, A; Dobrogowska, A; Dontabhaktuni, A; Lam, TS; Lee, H; Manolas, T; Mohammad, S; Patel, C; Patel, R; Patel, S; Phadke, S; Ray, SD; Rotollo, JA; Stohs, S; Strika, S	1
Bhattachar, SN; Fioritto, AF; Wesley, JA	1
Kaukonen, AM; Laitinen, L; Marvola, M; Takala, E; Vuorela, H; Vuorela, P	1
Benson, CA; Goldring, CE; Kitteringham, NR; Metcalfe, PN; Park, BK; Randle, LE; Williams, DP	1
Masumoto, H; Mitsuru, A; Okazaki, O; Sudo, K; Takakusa, H	1
Castellano, PM; Kaufman, TS; Maggio, RM	1
Abazia, DT; Marcus, A; Ross, J; Sachinwalla, E; Smolarz, BG	1
Masubuchi, Y; Nakayama, J; Sadakata, Y	1
Ghanam, D; Kleinebudde, P	1
Bryant, SC; Gastineau, DA; Greiner, CW; Hogan, WJ; Jacob, EK; Lingineni, RK; Mohr, A; Mulay, SB; Padley, D	1
Bogomolov, VV; Kondratenko, SN; Kovachevich, IV	1
Barcellini-Couget, S; de Sousa, G; Luzy, AP; Peyre, L; Rahmani, R; Zucchini-Pascal, N	1
Ros Forteza, FJ	1
Bonsante, F; Gambacorta, S; Gouyon, B; Gouyon, JB; Iacobelli, S; Laforgia, N; Lorrain, S	1
Aubrecht, J; Boucher, GG; Church, RJ; Eaddy, JS; Kreeger, JM; Schomaker, SJ; Watkins, PB	1
Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Sridharan, K	1
Elenga, N; Fremery, A; Geoffroy, S; Lambert, Y; Marty, C	1
Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Al Segai, O; Hashem Ahmed, H; Husain Shaban, G; Malalla, Z; Saeed Tabbara, K; Sridharan, K	1
Badriddinova, LY; Kondratenko, SN; Kovachevich, IV; Polyakov, AV; Repenkova, LG; Savelyeva, MI; Shikh, EV; Svistunov, AA	1
Correia, AT; Guimarães, LL; Roveri, V; Toma, W	1
Armanious, H; Bristow, E; Dinakaran, D; Garros, D; Noga, M; Sergi, C; Yap, J	1
Ajaz, M; Akram, M; Asif, HM; Daniyal, M; Hussain, A; Khan, FS; Shah, SMA; Tahir, IM	1

Reviews

9 review(s) available for furosemide and acetaminophen

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interactions with antiepileptic drugs. Drugs, 1977, Volume: 13, Issue:4 Topics: Acetaminophen; Acetazolamide; Anti-Anxiety Agents; Anticoagulants; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Furosemide; Gonadal Steroid Hormones; Griseofulvin; Humans; Phenobarbital; Phenytoin; Primidone; Thiazines; Urea; Valproic Acid; Vitamin D	1977
Drug metabolism in the production of liver injury. The Medical clinics of North America, 1975, Volume: 59, Issue:4 Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Drug Hypersensitivity; Ethers; Furosemide; Glutathione; Halothane; Humans; Inactivation, Metabolic; Isoniazid; Liver; Liver Neoplasms; Necrosis; Pharmaceutical Preparations; Phenacetin; Protein Binding; Thiophenes	1975
Reported ocular side effects of the ten most frequently prescribed drugs. Journal of the American Optometric Association, 1979, Volume: 50, Issue:2 Topics: Acetaminophen; Ampicillin; Brompheniramine; Codeine; Diazepam; Digoxin; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Eye; Eye Diseases; Female; Furosemide; Humans; Hydrochlorothiazide; Methyldopa; Phenylephrine; Phenylpropanolamine; Pregnancy; Propranolol; Tetracyclines; Triamterene	1979
Metabolic activation: biochemical basis for many drug-induced liver injuries. Progress in liver diseases, 1976, Volume: 5 Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hydrazines; Isoniazid; Liver; Methyldopa; Necrosis; Pharmaceutical Preparations; Phenacetin; Thiophenes	1976
The problem of chemically reactive metabolites. Drug metabolism reviews, 1982, Volume: 13, Issue:6 Topics: Acetaminophen; Animals; Biotransformation; Chemical Phenomena; Chemistry; Chloroform; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Isoniazid; Kinetics; Pharmaceutical Preparations; Terpenes	1982
Drug-induced pancreatitis: a critical review. Gastroenterology, 1980, Volume: 78, Issue:4 Topics: Acetaminophen; Adrenal Cortex Hormones; Amphetamines; Asparaginase; Azathioprine; Chlorthalidone; Cholestyramine Resin; Cimetidine; Cyproheptadine; Dextropropoxyphene; Diazoxide; Diuretics; Estrogens; Ethacrynic Acid; Furosemide; Histamine; Humans; Hypercalcemia; Indomethacin; Isoniazid; Mercaptopurine; Narcotics; Pancreatitis; Phenformin; Procainamide; Rifampin; Salicylates; Sodium Chloride Symporter Inhibitors; Sulfonamides; Tetracycline	1980

Trials

2 trial(s) available for furosemide and acetaminophen

Article	Year
The interaction of paracetamol with frusemide. British journal of clinical pharmacology, 1994, Volume: 37, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Adult; Dinoprostone; Diuresis; Drug Interactions; Female; Furosemide; Humans; Middle Aged; Natriuresis; Radioimmunoassay; Renin	1994
The effect of hypoxaemia on drug disposition in chronic respiratory failure. European journal of clinical pharmacology, 1996, Volume: 50, Issue:1-2 Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biological Availability; Chronic Disease; Cross-Over Studies; Female; Furosemide; Humans; Hypoglycemic Agents; Hypoxia; Male; Middle Aged; Oxygen Consumption; Protein Binding; Respiratory Insufficiency	1996

Article

Year

The interaction of paracetamol with frusemide.

British journal of clinical pharmacology, 1994, Volume: 37, Issue:5

Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Adult; Dinoprostone; Diuresis; Drug Interactions; Female; Furosemide; Humans; Middle Aged; Natriuresis; Radioimmunoassay; Renin

1994

The effect of hypoxaemia on drug disposition in chronic respiratory failure.

European journal of clinical pharmacology, 1996, Volume: 50, Issue:1-2

Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biological Availability; Chronic Disease; Cross-Over Studies; Female; Furosemide; Humans; Hypoglycemic Agents; Hypoxia; Male; Middle Aged; Oxygen Consumption; Protein Binding; Respiratory Insufficiency

1996

Other Studies

72 other study(ies) available for furosemide and acetaminophen

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:9 Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Biochemical changes after hepatic injury from toxic doses of acetaminophen or furosemide. Pharmacology, 1976, Volume: 14, Issue:3 Topics: Acetaminophen; Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Ethylmorphine-N-Demethylase; Furosemide; Glucose-6-Phosphatase; Glucuronosyltransferase; Liver; Male; Mice; Microsomes, Liver; Proteins	1976
Biochemical changes after hepatic injury by allyl alcohol and N-hydroxy-2-acetylaminofluorene. Chemico-biological interactions, 1976, Oct-02, Volume: 15, Issue:2 Topics: Acetaminophen; Allyl Compounds; Aniline Hydroxylase; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Cytochromes; Cytosol; Dimethylnitrosamine; Ethylmorphine-N-Demethylase; Fluorenes; Furosemide; Glucose-6-Phosphatase; Hydroxyacetylaminofluorene; Liver; Liver Regeneration; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrogenase; Proteins; Rats	1976
Methyldopa binding to cells in culture. Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:1 Topics: Acetaminophen; Allopurinol; Animals; Ascorbic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Deferoxamine; Dimethylnitrosamine; Edetic Acid; Furosemide; Glutathione; Liver Neoplasms; Maleates; Methyldopa; Neoplasms, Experimental; Protein Binding; Rats; Superoxide Dismutase; Time Factors; Xanthines	1977
The role of metabolic activation for drug-induced liver injuries. Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Isoniazid; Liver; Methyldopa	1977
Oxacillin and hepatotoxicity. Annals of internal medicine, 1979, Volume: 90, Issue:3 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Meprobamate; Oxacillin; Prochlorperazine	1979
Activation of alpha-methyldopa, paracetamol and furosemide by human liver microsomes. Acta pharmacologica et toxicologica, 1977, Volume: 41, Issue:1 Topics: Acetaminophen; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Furosemide; Humans; Methyldopa; Microsomes, Liver	1977
Molecular basis for several drug-induced nephropathies. The American journal of medicine, 1977, Volume: 62, Issue:4 Topics: Acetaminophen; Analgesics; Animals; Carbon Tetrachloride Poisoning; Cephaloridine; Chloroform; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Furosemide; Glutathione; Humans; Kidney; Kidney Diseases; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Protein Binding; Salicylates; Toxicology	1977
The role of biotransformation in chemical-induced liver injury. Environmental health perspectives, 1976, Volume: 15 Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cricetinae; Furosemide; Glutathione; Guinea Pigs; Humans; In Vitro Techniques; Iproniazid; Isoniazid; Liver Diseases; Methylcholanthrene; Mice; Phenobarbital; Rats	1976
Progress in hepatology. Metabolic activation of drugs to toxic substances. Gastroenterology, 1975, Volume: 68, Issue:2 Topics: Acetaminophen; Animals; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cricetinae; Furosemide; Hemolysis; Humans; Isoniazid; Kidney Diseases; Kinetics; Liver; Lung Diseases; Mice; Protein Binding; Toxicology; Tritium	1975
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Isoniazid; Liver; Methyldopa; Necrosis	1976
Pseudotumor cerebri and pregnancy. American journal of perinatology, 1989, Volume: 6, Issue:4 Topics: Acetaminophen; Acetazolamide; Codeine; Female; Furosemide; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complications; Pseudotumor Cerebri; Tomography, X-Ray Computed	1989
Comparison of the susceptibility of hepatocytes from postnatal and adult mice to hepatotoxins. Biochemical pharmacology, 1988, Nov-01, Volume: 37, Issue:21 Topics: Acetaminophen; Aging; Animals; Animals, Newborn; Catalase; Furosemide; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Iodoacetates; Iodoacetic Acid; L-Lactate Dehydrogenase; Liver; Peroxides; Superoxide Dismutase; tert-Butylhydroperoxide; Time Factors	1988
The effects of paracetamol on frusemide ototoxicity. Audiology : official organ of the International Society of Audiology, 1985, Volume: 24, Issue:4 Topics: Acetaminophen; Action Potentials; Animals; Auditory Threshold; Dose-Response Relationship, Drug; Drug Interactions; Furosemide; Guinea Pigs; Time Factors	1985
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity. Biochemical pharmacology, 1974, Oct-15, Volume: 23, Issue:20 Topics: Acetaminophen; Animals; Autoradiography; Benzene Derivatives; Carbon Tetrachloride Poisoning; Carcinogens; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Culture Techniques; Drug Stability; Furosemide; Hydrocarbons, Halogenated; Kinetics; Liver; Mutagens; Necrosis; Toxicology	1974
Free radicals in vivo. Covalent binding to lipids. Molecular pharmacology, 1984, Volume: 26, Issue:1 Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Dimethylnitrosamine; Free Radicals; Furans; Furosemide; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred ICR; Rats; Rats, Inbred Strains	1984
Early reports on drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine	1983
Influence of cohesive properties of micronized drug powders on particle size analysis. Journal of pharmaceutical and biomedical analysis, 1995, Volume: 13, Issue:3 Topics: Acetaminophen; Chemical Phenomena; Chemistry, Physical; Chloramphenicol; Drug Compounding; Furosemide; Microscopy, Electron, Scanning; Particle Size; Powders; Surface Properties	1995
Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo. Chemical research in toxicology, 2000, Volume: 13, Issue:9 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Coenzyme A; Disease Models, Animal; Furosemide; Glutathione; Liver; Male; Mass Spectrometry; Mice; Mice, Inbred ICR	2000
A comparison of drug loading capacity of cellactose with two ad hoc processed lactose-cellulose direct compression excipients. Chemical & pharmaceutical bulletin, 2004, Volume: 52, Issue:4 Topics: Acetaminophen; Cellulose; Diuretics; Drug Compounding; Excipients; Furosemide; Kinetics; Lactose; Mercury; Particle Size; Porosity; Solubility; Surface Properties; Tablets; Tensile Strength	2004
Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo. BioFactors (Oxford, England), 2004, Volume: 21, Issue:1-4 Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Apoptosis; Cell Death; Furosemide; Liver; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Phytotherapy; Plant Extracts; Reactive Oxygen Species	2004
Solubility measurement of polymorphic compounds via the pH-metric titration technique. International journal of pharmaceutics, 2007, Feb-07, Volume: 330, Issue:1-2 Topics: Acetaminophen; Acetazolamide; Chlorpropamide; Crystallography, X-Ray; Fluoroquinolones; Furosemide; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Potentiometry; Pyrroles; Quinolones; Solubility; Sulfamethoxazole; Sulfathiazole; Sulfathiazoles; Thermodynamics; Titrimetry	2007
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2). European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2007, Volume: 66, Issue:1 Topics: Absorption; Acetaminophen; Anthraquinones; Beverages; Caco-2 Cells; Carbon Radioisotopes; Cathartics; Cell Membrane Permeability; Digoxin; Furosemide; Humans; Ketoprofen; Mannitol; Plant Leaves; Propranolol; Senna Extract; Sennosides; Verapamil	2007
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. Toxicology, 2008, Jan-20, Volume: 243, Issue:3 Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Alanine Transaminase; Analysis of Variance; Animals; Blotting, Western; Bromobenzenes; Carbon Tetrachloride; Cell Nucleus; Cytoskeletal Proteins; Furosemide; Glutamate-Cysteine Ligase; Glutathione; Heme Oxygenase-1; Injections, Intraperitoneal; Kelch-Like ECH-Associated Protein 1; Liver; Male; Mice; Molecular Structure; NF-E2-Related Factor 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Xenobiotics	2008
Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5 Topics: Acetaminophen; Aspirin; Butylated Hydroxyanisole; Carboxylic Ester Hydrolases; Cells, Cultured; Clozapine; Diclofenac; Furosemide; Glucuronosyltransferase; Heme Oxygenase-1; Hepatocytes; Humans; L-Lactate Dehydrogenase; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; RNA, Messenger; Ticlopidine; Ticrynafen	2008
A new principal component analysis-based approach for testing "similarity" of drug dissolution profiles. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, May-10, Volume: 34, Issue:1 Topics: Acetaminophen; Furosemide; Pharmaceutical Preparations; Principal Component Analysis; Solubility; Tablets	2008
Noncardiogenic pulmonary edema in a patient receiving vancomycin and oxycodone-acetaminophen. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2008, Volume: 100, Issue:6 Topics: Acetamides; Acetaminophen; Analgesics; Anti-Infective Agents; Cellulitis; Diphenhydramine; Drug Combinations; Famotidine; Furosemide; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Oxycodone; Pulmonary Edema; Staphylococcal Skin Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin	2008
Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury. Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Female; Furosemide; Glutathione; Interleukin-6; Liver; Male; Mice; Mice, Inbred Strains	2011
Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization. Drug development and industrial pharmacy, 2011, Volume: 37, Issue:4 Topics: Acetaminophen; Chemistry, Pharmaceutical; Furosemide; Hydrochlorothiazide; Particle Size; Solubility; Technology, Pharmaceutical; Tensile Strength; Theophylline	2011
Infusion technique of hematopoietic progenitor cells and related adverse events (CME). Transfusion, 2014, Volume: 54, Issue:8 Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Preservation; Child; Child, Preschool; Cryopreservation; Cryoprotective Agents; Dimethyl Sulfoxide; Diphenhydramine; Flushing; Furosemide; Hematologic Neoplasms; Humans; Hydrocortisone; Hypertension; Infant; Infant, Newborn; Infusions, Intravenous; Isotonic Solutions; Middle Aged; Nausea; Neutrophils; Peripheral Blood Stem Cell Transplantation; Premedication; Retrospective Studies; Risk Factors; Syringes; Young Adult	2014
[TESTING STABILITY OF TABLETED ACETAMINOPHEN AND FUROSEMIDE AFTER 6-MONTH STORAGE IN SPACE FLIGHT]. Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, 2015, Volume: 49, Issue:2 Topics: Acetaminophen; Drug Storage; Furosemide; Humans; Materials Testing; Space Flight; Spacecraft; Tablets; Weightlessness	2015
High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical's bio-activation with regards hepatotoxicity. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:7 Topics: Acetaminophen; Amodiaquine; Animals; Carbamazepine; Cell Line, Tumor; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Diethylstilbestrol; Erythromycin; Furosemide; Hepatocytes; High-Throughput Screening Assays; Male; Neutral Red; Rats; Toxicity Tests; Tretinoin	2015
Alzheimer disease triggered by reversible posterior leukoencephalopathy syndrome. Neurologia, 2020, Volume: 35, Issue:4 Topics: Acetaminophen; Aged; Alzheimer Disease; Analgesics, Non-Narcotic; Antihypertensive Agents; Captopril; Diuretics; Female; Furosemide; Headache; Humans; Hypertension; Magnetic Resonance Imaging; Photophobia; Posterior Leukoencephalopathy Syndrome; Sex Factors; Spain	2020
Drug exposure for PDA closure in France: a prospective, cohort-based, analysis. European journal of clinical pharmacology, 2020, Volume: 76, Issue:12 Topics: Acetaminophen; Administration, Oral; Drug Resistance; Drug Utilization; Ductus Arteriosus, Patent; Female; France; Furosemide; Hospitalization; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Male; Practice Patterns, Physicians'; Prospective Studies; Treatment Outcome	2020
Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse. PloS one, 2020, Volume: 15, Issue:10 Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Furosemide; Glutamate Dehydrogenase; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitophagy	2020
Intravenous frusemide does not interact pharmacodynamically with acetaminophen in critically ill preterm neonates with patent ductus arteriosus. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:3 Topics: Acetaminophen; Administration, Intravenous; Critical Illness; Ductus Arteriosus, Patent; Female; Furosemide; Humans; Infant, Premature; Male; Prospective Studies	2021
Case Report: Acute Kidney Failure due to Massive Envenomation of a Two-Year-Old Child Caused by Killer Bee Stings. The American journal of tropical medicine and hygiene, 2021, 05-10, Volume: 105, Issue:1 Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Bee Venoms; Bees; Child, Preschool; Chlorpheniramine; Female; French Guiana; Furosemide; Glucocorticoids; Histamine H1 Antagonists; Humans; Insect Bites and Stings; Prednisolone	2021
Biomarkers in neonates receiving potential nephrotoxic drugs. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:22 Topics: Acetaminophen; Adult; Amikacin; Biomarkers; Cystatins; Female; Furosemide; Gentamicins; Hepatitis A Virus Cellular Receptor 1; Humans; Ibuprofen; Infant, Newborn; Kidney Diseases; Lipocalin-2; Male; Middle Aged; Vancomycin	2021
Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions. Drug metabolism and personalized therapy, 2021, 11-29, Volume: 37, Issue:2 Topics: Acetaminophen; Furosemide; Humans; Hypokinesia; Pharmaceutical Preparations; Propranolol; Space Flight; Verapamil	2021
Occurrence, ecological risk assessment and prioritization of pharmaceuticals and abuse drugs in estuarine waters along the São Paulo coast, Brazil. Environmental science and pollution research international, 2022, Volume: 29, Issue:59 Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Diclofenac; Ecosystem; Environmental Monitoring; Furosemide; Illicit Drugs; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Rivers; Tandem Mass Spectrometry; Water Pollutants, Chemical	2022
Co-ingestion of willow bark tea and acetaminophen associated with fatal infantile fulminant liver failure. Pediatrics international : official journal of the Japan Pediatric Society, 2017, Volume: 59, Issue:6 Topics: Acetaminophen; Antipyretics; Child, Preschool; Fatal Outcome; Humans; Liver Failure, Acute; Male; Medicine, Traditional; Plant Bark; Salix; Tea	2017
Phytochemical screening and antipyretic effects of hydroalcoholic extracts of selected medicinal plants of Rawalakot, Azad Jammu and Kashmir in albino rats. Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:2 Topics: Acetaminophen; Achillea; Animals; Antipyretics; Drug Evaluation, Preclinical; Female; Fever; Male; Pakistan; Phytochemicals; Plant Extracts; Plants, Medicinal; Rats; Salix; Taraxacum; Trigonella	2019